Opportunity Information: Apply for RFA RM 12 005

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Human Heredity and Health in Africa (H3Africa) Ethical, Legal, and Societal Issues (ELSI) Research Program (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
  • This funding opportunity was created on Oct 26, 2012 and posted on Jun 13, 2012.
  • Applicants must submit their applications by Oct 31, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $162,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $50,000.00 in funding.
  • Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
  • Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Organizations) Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Human Heredity and Health in Africa (H3Africa) Ethical, Legal, and Societal Issues (ELSI) Research Program (U01) funding opportunity (Funding Opportunity Number RFA-RM-12-005) was issued by the National Institutes of Health (NIH) to support targeted research on the ethical, legal, and societal issues that arise in the context of human genome research involving African populations. The main purpose is to generate practical, evidence-based insight into how genomic research is conducted, governed, understood, and experienced in African settings, with a strong emphasis on identifying and analyzing new or emerging ELSI challenges. Rather than funding large, multi-year infrastructure efforts, the announcement is aimed at small, self-contained projects that can tackle specific questions using bioethics, legal scholarship, and social science approaches.

This FOA uses a cooperative agreement mechanism (U01), which generally means the work is supported as a research project while also involving a more active programmatic role for NIH compared with a standard grant. The activity category is health, and the listing appears under CFDA 93.310 (Trans-NIH Research Support). The announcement explicitly frames the scientific scope around the realities of genomics research in Africa, where issues such as informed consent practices, community engagement, benefit sharing, data and sample governance, privacy protections, cultural considerations, and the handling of incidental or secondary findings can present complex, context-specific questions. The FOA signals particular interest in studies that move beyond broad discussion and instead provide focused analyses of concrete, contemporary problems, especially those prompted by advances in genomic technologies, expanding biobanks, large-scale data sharing, and cross-border research collaborations.

In terms of funding, the opportunity lists an estimated total funding amount of $162,000 and an award ceiling of $50,000, reinforcing the expectation that applications propose modest, well-scoped projects with clear deliverables. There is no cost sharing or matching requirement, which lowers barriers for applicants that may not have institutional resources to contribute financially. Key dates show it was posted on June 13, 2012, created on October 26, 2012, and had an original closing date of October 29, 2012, later updated to a current closing date of October 31, 2012, with an archive date of November 30, 2012. Those dates indicate it was a time-limited call tied to early phases of H3Africa-related program development and the need to quickly build an evidence base around ELSI considerations.

Eligibility is broad and includes private and public institutions of higher education as well as additional eligible applicants described in the announcement. Importantly, foreign participation is clearly allowed: non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations may apply, and foreign components (as defined by NIH policy) are permitted. This matters for an Africa-focused ELSI program because it enables Africa-based universities, research institutes, and ethics or policy centers to apply directly, and it supports equitable leadership or partnership models that reflect local expertise and on-the-ground knowledge of legal systems, cultural norms, and health research governance structures.

For applicants and institutions trying to locate the full requirements and application instructions, the FOA provides an official NIH link to the archived announcement at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-005.html. For access issues or technical problems connecting to the funding announcement, the contact point listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs)

What is the funding opportunity called?

The opportunity is the Human Heredity and Health in Africa (H3Africa) Ethical, Legal, and Societal Issues (ELSI) Research Program (U01). The Funding Opportunity Number is RFA-RM-12-005.

Who issued this funding opportunity?

This funding opportunity was issued by the National Institutes of Health (NIH).

What is the main purpose of this FOA?

The main purpose is to support targeted research on ethical, legal, and societal issues (ELSI) that arise in the context of human genome research involving African populations, with an emphasis on generating practical, evidence-based insights grounded in African settings.

What kinds of research questions is the FOA trying to answer?

The FOA focuses on how genomic research is conducted, governed, understood, and experienced in African contexts, and it places strong emphasis on identifying and analyzing new or emerging ELSI challenges associated with modern genomics research.

What does the FOA mean by "ELSI" in this context?

In this announcement, ELSI refers to ethical, legal, and societal issues connected to genomics research involving African populations, including how research practices and policies affect participants, communities, institutions, and cross-border collaborations.

Is this FOA intended to fund large infrastructure or long-term capacity-building projects?

No. The announcement explicitly indicates it is not aimed at large, multi-year infrastructure efforts. Instead, it targets small, self-contained projects designed to address specific, well-defined questions with clear deliverables.

What approach or disciplines does the FOA expect applicants to use?

The FOA indicates projects can tackle focused questions using bioethics, legal scholarship, and social science approaches.

What is the award mechanism and what does it imply?

The FOA uses a cooperative agreement mechanism (U01). This generally means the project is supported as research while NIH has a more active programmatic role than it would under a standard grant mechanism.

What is the activity category and CFDA listing for this opportunity?

The activity category is health, and the listing appears under CFDA 93.310 (Trans-NIH Research Support).

What types of ELSI topics are specifically highlighted as relevant in African genomics settings?

The FOA frames its scientific scope around Africa-specific realities in genomics research and highlights issues such as informed consent practices, community engagement, benefit sharing, data and sample governance, privacy protections, cultural considerations, and the handling of incidental or secondary findings.

Does the FOA encourage broad discussions about ELSI, or more specific studies?

The FOA signals particular interest in studies that move beyond broad discussion and instead provide focused analyses of concrete, contemporary problems, especially those prompted by advances in genomic technologies, expanding biobanks, large-scale data sharing, and cross-border research collaborations.

How much funding is available under this opportunity?

The opportunity lists an estimated total funding amount of $162,000.

What is the maximum award amount per project?

The award ceiling is $50,000, reinforcing that proposed projects should be modest in scope and tightly focused.

Is cost sharing or matching required?

No. The FOA states there is no cost sharing or matching requirement.

When was the FOA posted and when did it close?

Key dates listed include: posted on June 13, 2012; created on October 26, 2012; original closing date of October 29, 2012; later updated to a current closing date of October 31, 2012; and an archive date of November 30, 2012.

Is this a current, open funding opportunity?

Based on the dates provided, the FOA was time-limited and is archived (archive date: November 30, 2012), indicating it is not an active, open call.

Who is eligible to apply?

Eligibility is broad and includes private and public institutions of higher education, as well as additional eligible applicants described in the announcement.

Are foreign organizations eligible to apply?

Yes. Foreign participation is clearly allowed. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply.

Can non-U.S. components of U.S. organizations apply?

Yes. The FOA states that non-U.S. components of U.S. organizations may apply.

Are foreign components permitted under NIH policy for this FOA?

Yes. The FOA states that foreign components (as defined by NIH policy) are permitted.

Why does the FOA emphasize allowing foreign participation?

The program is Africa-focused, and allowing foreign participation enables Africa-based universities, research institutes, and ethics or policy centers to apply directly and support leadership and partnership models grounded in local expertise and governance realities.

Where can applicants find the full, official FOA text and instructions?

The FOA provides an official NIH link to the archived announcement: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-005.html.

Who should be contacted for access issues or technical problems related to the FOA page?

For access issues or technical problems connecting to the funding announcement, the FOA lists the NIH Office of Extramural Research (OER) Webmaster: FBOWebmaster@OD.NIH.GOV.

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