Opportunity Information: Apply for RFA DK 16 023
Apply for RFA DK 16 023
- The HHS-NIH11 in the food and nutrition, health sector is offering a public funding opportunity titled "Human Islet Distribution Coordinating Center (UC4)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on Mar 31, 2016 and posted on Mar 31, 2016.
- Applicants must submit their applications by Nov 22, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,300,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Human Islet Distribution Coordinating Center (UC4) funding opportunity (RFA-DK-16-023) is a cooperative agreement from the National Institutes of Health, within HHS (listed as HHS-NIH11), focused on keeping the Integrated Islet Distribution Program (IIDP) running through a central coordinating hub. The IIDP exists to make human cadaveric pancreatic islets available to the biomedical research community, since these primary human tissues are a cornerstone resource for studying diabetes, human islet cell biology, and potential therapeutic approaches. Rather than funding individual research projects, this grant supports the infrastructure that makes high-quality human islets easier to obtain, more consistently characterized, and more reliably distributed across many investigators and institutions.
At the center of the program is the IIDP Coordinating Center (IIDP-CC), which is responsible for organizing and overseeing the entire distribution pipeline. A key part of that role is subcontracting with qualified islet isolation facilities that can procure, isolate, prepare, and distribute human islets suitable for research use. The coordinating center is also expected to run and manage the investigator access process, meaning it sets up and administers the application workflow used to determine whether an investigator and their institution are eligible to receive islets. Once approved, investigators are maintained in an official roster of authorized recipients, creating a structured, auditable list of researchers who can request and receive this material.
The FOA also emphasizes operational services that make the system function efficiently in real time. The coordinating center is expected to implement a notification system that alerts approved investigators when islets become available, helping match limited, time-sensitive supply to research demand. In parallel, it must run a cost recovery system supported by fees collected from islet recipients. This is meant to offset operational expenses and help sustain the distribution infrastructure, while still keeping access organized through a centralized program rather than leaving each researcher to negotiate individually with isolation sites.
Quality is treated as a major program outcome, not a side detail. The coordinating center is tasked with overseeing quality control processes across the program, with the goal of monitoring islet quality and driving improvements and standardization across participating isolation facilities. Because human islets can vary due to donor factors, procurement conditions, isolation methods, and shipping variables, a centralized QC and continuous improvement framework helps make the resource more reliable for downstream studies and improves comparability of results across labs.
From an administrative standpoint, this opportunity is categorized as discretionary and uses a cooperative agreement mechanism (UC4), which generally means NIH expects substantial programmatic involvement and coordination rather than a hands-off grant. The activity area is health (with listing under Food and Nutrition, Health) and the CFDA number provided is 93.847. The FOA anticipated a single award (ExpectedAwards: 1), with an award ceiling of $1,300,000. The opportunity was posted and created on March 31, 2016, with an original and current closing date of November 22, 2016.
Eligibility is broad and includes many types of organizations that can credibly run a national-scale coordinating center: state, county, and local governments; public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including entities other than small businesses as well as small businesses); Native American tribal governments and tribal organizations; public housing authorities/Indian housing authorities; and other applicants as further clarified in the FOA’s additional eligibility notes. In practical terms, the applicant needs to demonstrate it can manage subcontracts, compliance and eligibility review, communications and logistics systems, fee-based cost recovery, and a rigorous quality framework, all while serving a broad national research community that depends on timely and standardized access to human islets.
Frequently Asked Questions (FAQs) - Human Islet Distribution Coordinating Center (UC4) (RFA-DK-16-023)
What is this funding opportunity?
This opportunity (RFA-DK-16-023) funds the Human Islet Distribution Coordinating Center (IIDP-CC) through a cooperative agreement (UC4) from the National Institutes of Health (NIH) within HHS (listed as HHS-NIH11). The purpose is to keep the Integrated Islet Distribution Program (IIDP) operating through a central coordinating hub.
What is the goal of the Integrated Islet Distribution Program (IIDP)?
The IIDP exists to make human cadaveric pancreatic islets available to the biomedical research community. These primary human tissues are described as a cornerstone resource for studying diabetes, human islet cell biology, and potential therapeutic approaches.
Does this grant fund individual research projects?
No. The program is described as supporting infrastructure rather than funding individual research projects. It focuses on making high-quality human islets easier to obtain, more consistently characterized, and more reliably distributed across many investigators and institutions.
What entity is being supported by this award?
The award supports the IIDP Coordinating Center (IIDP-CC), which organizes and oversees the full islet distribution pipeline for the program.
What are the core responsibilities of the IIDP Coordinating Center?
Based on the information provided, the coordinating center is responsible for: subcontracting with qualified islet isolation facilities; managing the investigator access process and eligibility workflow; maintaining an official roster of authorized recipients; implementing an islet availability notification system; operating a fee-based cost recovery system; and overseeing quality control (QC) and continuous improvement across participating facilities.
What does it mean that this is a cooperative agreement (UC4)?
A UC4 cooperative agreement is noted as a mechanism where NIH expects substantial programmatic involvement and coordination, rather than a hands-off grant relationship.
What kinds of organizations can apply?
Eligibility is described as broad and includes: state, county, and local governments; public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and entities other than small businesses); Native American tribal governments and tribal organizations; public housing authorities/Indian housing authorities; and other applicants as further clarified in the FOA's additional eligibility notes.
Is the award intended for more than one recipient?
No. The FOA anticipated a single award (ExpectedAwards: 1).
What is the maximum funding amount mentioned for this opportunity?
The award ceiling listed is $1,300,000.
When was the opportunity posted, and what was the closing date?
The opportunity was posted and created on March 31, 2016. The original and current closing date shown is November 22, 2016.
What is the CFDA number associated with this opportunity?
The CFDA number provided is 93.847.
What is the activity area or topic category for this opportunity?
The activity area is described as health, with listing under Food and Nutrition, Health.
What is the role of islet isolation facilities within this program?
The coordinating center is expected to subcontract with qualified islet isolation facilities. These facilities procure, isolate, prepare, and distribute human islets suitable for research use, operating as part of the centralized IIDP pipeline overseen by the coordinating center.
How does the investigator access process work under the coordinating center?
The coordinating center is expected to set up and administer the application workflow used to determine whether an investigator and their institution are eligible to receive islets. Approved investigators are then maintained in an official roster of authorized recipients.
What is the purpose of maintaining an official roster of authorized recipients?
The roster creates a structured, auditable list of researchers who are approved to request and receive human islets through the program.
Why does the FOA require a notification system for islet availability?
The notification system is intended to alert approved investigators when islets become available, helping match a limited, time-sensitive supply of islets to research demand.
What is meant by a cost recovery system in this program?
The coordinating center must run a cost recovery system supported by fees collected from islet recipients. These fees are intended to offset operational expenses and help sustain the distribution infrastructure while keeping access organized through a centralized program.
Why is quality control (QC) emphasized in this opportunity?
Quality is described as a major program outcome. The coordinating center is tasked with overseeing QC processes to monitor islet quality and drive improvements and standardization across participating isolation facilities.
What factors can cause variation in human islet quality according to the description?
The description notes that human islets can vary due to donor factors, procurement conditions, isolation methods, and shipping variables.
What is the intended benefit of centralized QC and continuous improvement?
A centralized QC and continuous improvement framework is described as helping make the islet resource more reliable for downstream studies and improving comparability of results across labs.
What capabilities should an applicant demonstrate to run the coordinating center?
Applicants should be able to manage subcontracts; handle compliance and eligibility review; operate communications and logistics systems; implement fee-based cost recovery; and maintain a rigorous quality framework, while serving a broad national research community that depends on timely and standardized access to human islets.
Which federal agency is associated with this opportunity?
The opportunity is from the National Institutes of Health (NIH) within the Department of Health and Human Services (HHS), listed as HHS-NIH11.
How is this opportunity categorized from an administrative standpoint?
It is categorized as discretionary and uses a cooperative agreement mechanism (UC4).
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