Opportunity Information: Apply for RFA DK 15 027
Apply for RFA DK 15 027
- The HHS-NIH11 in the food and nutrition, health sector is offering a public funding opportunity titled "Human Pancreas Procurement and Analysis Program (HPPAP) (UC4)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847,.
- This funding opportunity was created on Oct 29, 2015 and posted on Oct 29, 2015.
- Applicants must submit their applications by Mar 03, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,300,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Human Pancreas Procurement and Analysis Program (HPPAP) (UC4) is a National Institutes of Health (NIH) cooperative agreement funding opportunity (RFA-DK-15-027) designed to build and run a centralized program for obtaining, deeply characterizing, and broadly sharing human pancreatic tissue and associated datasets. The overall goal is to accelerate research on type 1 diabetes (T1D) by making high-quality human pancreas specimens and richly linked biological data available to the wider scientific community, and by organizing those data into an open-access resource.
At the core of the program is the creation of a coordinated, multidisciplinary team with expertise spanning human pancreas physiology and disease processes, tissue procurement and handling, advanced laboratory analysis, and the integration of complex biological datasets. The funded group is expected to operate as a service-and-resource hub rather than as a single-lab research project. Because this is a cooperative agreement (UC4), NIH has an active partnership role, meaning the awardee is expected to coordinate closely with NIH program staff and align activities with broader network priorities and shared standards.
HPPAP has three main responsibilities. First, the program must collect primary pancreatic tissues from key donor groups: individuals with established T1D, individuals in a pre-T1D stage (specifically those positive for multiple islet autoantibodies), and people with rare forms of islet dysfunction. These tissues must then be intensively characterized, which implies generating comprehensive molecular, cellular, and pathological profiles and capturing extensive metadata about the specimens. Second, the program must distribute these specimens along with their linked data to external investigators, enabling many research groups to conduct additional analyses and pursue new questions without each needing to independently solve the major logistical and ethical hurdles of sourcing human pancreatic tissue. Third, the program must organize and integrate all collected data into an open-access database called PANC DB, intended to function as a community resource where researchers can access, explore, and reuse well-annotated datasets derived from these tissues.
This program is explicitly positioned as a component of the Human Islet Research Network (HIRN), an NIH-supported initiative launched in 2014 to promote collaborative, translational research focused on understanding how functional human beta cell mass is lost in T1D and how it might be protected or replaced. In practical terms, HPPAP serves as enabling infrastructure for HIRN and the broader diabetes research field by standardizing access to rare human samples and by providing integrated datasets that can support multi-omics analyses, cross-study comparisons, biomarker discovery, and mechanistic investigations grounded in human biology rather than relying solely on animal models.
From an administrative standpoint, the opportunity is offered by HHS/NIH (listed as HHS-NIH11) within the health-related funding activity area, with CFDA numbers 93.847 (and also listed with 93.847 under the announcement metadata). The FOA allowed applications from a wide range of organizations, including state and local governments, tribal governments and organizations, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and other entities as described in the full eligibility text. The announcement anticipated a single award (ExpectedAwards: 1) with an award ceiling of $2,300,000. The FOA was created and posted on October 29, 2015, and had an application closing date of March 3, 2016 (original and current closing dates are the same).
In summary, HPPAP (UC4) is a resource-building NIH program intended to transform access to human pancreatic tissues relevant to T1D and related islet disorders by combining standardized procurement, deep characterization, broad specimen and data distribution, and an open-access database (PANC DB). Its value is in enabling many downstream studies across the research community and strengthening the human-centered evidence base needed to develop strategies to prevent beta cell loss and restore beta cell function in T1D.
Frequently Asked Questions (FAQs): Human Pancreas Procurement and Analysis Program (HPPAP) (UC4)
What is the Human Pancreas Procurement and Analysis Program (HPPAP) (UC4)?
HPPAP (UC4) is a National Institutes of Health (NIH) cooperative agreement funding opportunity (RFA-DK-15-027) to build and operate a centralized program that obtains human pancreatic tissue, deeply characterizes those specimens, and broadly shares both the tissue and linked datasets with the research community.
What is the overall goal of HPPAP?
The goal is to accelerate type 1 diabetes (T1D) research by making high-quality human pancreas specimens and richly linked biological data available to the wider scientific community, and by organizing those data into an open-access resource.
What kind of award mechanism is used for this opportunity?
This opportunity uses a cooperative agreement mechanism (UC4). In a cooperative agreement, NIH is an active partner, and the awardee is expected to coordinate closely with NIH program staff and align work with broader network priorities and shared standards.
How is HPPAP different from a typical single-lab research project?
HPPAP is described as a service-and-resource hub rather than a single-lab research project. The funded group is expected to run a centralized program that enables many downstream studies by other investigators through standardized procurement, analysis, distribution, and data sharing.
What are the main responsibilities of the HPPAP program?
HPPAP has three main responsibilities: (1) collect primary pancreatic tissues from key donor groups and intensively characterize them; (2) distribute the specimens and linked data to external investigators; and (3) organize and integrate all collected data into an open-access database called PANC DB.
Which donor groups must HPPAP collect pancreatic tissue from?
The program must collect primary pancreatic tissues from: individuals with established T1D; individuals in a pre-T1D stage (specifically those positive for multiple islet autoantibodies); and people with rare forms of islet dysfunction.
What does "intensively characterized" mean in this program context?
It implies generating comprehensive molecular, cellular, and pathological profiles of the collected tissues, along with capturing extensive metadata about the specimens.
What is expected regarding specimen and data sharing?
HPPAP is expected to distribute collected specimens along with their linked data to external investigators. This is intended to allow multiple research groups to conduct additional analyses and pursue new questions without each group needing to independently address the logistical and ethical hurdles of sourcing human pancreatic tissue.
What is PANC DB?
PANC DB is the open-access database where HPPAP is expected to organize and integrate all collected data. It is intended to function as a community resource where researchers can access, explore, and reuse well-annotated datasets derived from the tissues collected and characterized by the program.
Is HPPAP connected to any larger NIH research initiative?
Yes. HPPAP is explicitly positioned as a component of the Human Islet Research Network (HIRN), an NIH-supported initiative launched in 2014 to promote collaborative, translational research focused on understanding how functional human beta cell mass is lost in T1D and how it might be protected or replaced.
What role does HPPAP play within HIRN and the broader research community?
HPPAP serves as enabling infrastructure by standardizing access to rare human pancreas samples relevant to T1D and related islet disorders, and by providing integrated datasets that support multi-omics analyses, cross-study comparisons, biomarker discovery, and mechanistic investigations grounded in human biology.
Who is the sponsoring agency for this funding opportunity?
The opportunity is offered by HHS/NIH (listed as HHS-NIH11) within the health-related funding activity area.
What is the Funding Opportunity Announcement (FOA) number for HPPAP?
The FOA is RFA-DK-15-027.
What is the CFDA number associated with this opportunity?
The opportunity lists CFDA number 93.847 (and also lists 93.847 under the announcement metadata).
What types of organizations were eligible to apply?
The FOA allowed applications from a wide range of organizations, including: state and local governments; tribal governments and organizations; public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and other entities as described in the full eligibility text.
How many awards were anticipated?
The announcement anticipated a single award (ExpectedAwards: 1).
What was the award ceiling for this opportunity?
The award ceiling was $2,300,000.
When was the FOA created and posted?
The FOA was created and posted on October 29, 2015.
What was the application closing date?
The application closing date was March 3, 2016 (the original and current closing dates were the same).
What types of research does this resource aim to enable?
By providing standardized access to high-quality human pancreatic tissues and integrated datasets, HPPAP is intended to enable downstream studies such as multi-omics analyses, cross-study comparisons, biomarker discovery, and mechanistic investigations that are grounded in human biology.
Why does the program emphasize human pancreatic tissue and human-centered datasets?
The program is positioned to strengthen the human-centered evidence base needed to develop strategies to prevent beta cell loss and restore beta cell function in T1D, supporting investigations that are not reliant solely on animal models.
What kind of team is expected to run HPPAP?
The program centers on a coordinated, multidisciplinary team with expertise spanning human pancreas physiology and disease processes, tissue procurement and handling, advanced laboratory analysis, and the integration of complex biological datasets.
What does NIH's "active partnership role" mean for the awardee?
Because this is a UC4 cooperative agreement, the awardee is expected to coordinate closely with NIH program staff and to align activities with broader network priorities and shared standards.
What is the core value proposition of HPPAP?
Its value is in enabling many downstream studies across the research community by combining standardized procurement, deep characterization, broad specimen and data distribution, and an open-access database (PANC DB).
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