Human Pluripotent Stem Cell (hPSC) Research Using Non Embryonic Sources (R21) | Apply Online

Opportunity Summary:

The Human Pluripotent Stem Cell (hPSC) Research Using Non Embryonic Sources (R21) opportunity (Funding Opportunity Number PA 08 044) is a National Institutes of Health (NIH) program announcement designed to stimulate early-stage, exploratory research on human pluripotent stem cells that do not come from embryonic sources. The central aim is to encourage new project ideas that focus on creating, isolating, producing, and testing stem cells that can generate all, or nearly all, of the cell types found in the developing human body, while avoiding any approach that involves creating a human embryo for research or destroying, discarding, or harming a human embryo. This emphasis directly reflects Executive Order 13435 (issued June 20, 2007), which directed the Department of Health and Human Services to support pluripotent stem cell research specifically grounded in non-embryonic derivation routes, with the long-term goal of improving understanding of disease and advancing potential treatments for a wide range of adverse health conditions.

The funding mechanism for this announcement is the NIH Exploratory/Developmental Grant Award (R21). In practice, that means the program is oriented toward high-risk, high-reward concepts, proof-of-concept studies, and the kind of early development work that can open a new line of investigation rather than fully mature, multi-year research programs. The FOA is described as agency-wide, meaning it is relevant across many NIH mission areas rather than being confined to a single institute or disease category. It also explicitly runs in parallel with a companion announcement of the same scientific scope that uses the R01 mechanism (PA 08 043), which is typically more appropriate for larger, more established projects with substantial preliminary data. Applicants who have an idea that is promising but still developmental in nature are generally aligned with the R21 approach, while those with a more advanced, comprehensive project could consider the parallel R01 route.

From an administrative and funding standpoint, awards under PA 08 044 depend on two things: the availability of NIH funds in a given cycle and the submission of enough applications that score well in peer review. The announcement lists an award ceiling of $200,000, indicating the upper limit of support under the terms summarized here. There is no cost sharing or matching requirement, so applicants are not required to contribute non-federal funds as a condition of the award.

Eligibility is broad and includes many common research-performing and public-serving entities. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, for-profit organizations other than small businesses, state and local governments (including county and city or township governments), special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. Importantly, foreign institutions are also eligible to apply, which expands the applicant pool beyond the United States and signals NIH openness to supporting scientifically strong proposals regardless of geography, provided all NIH policy requirements are met.

The opportunity was originally posted December 13, 2007, with a current closing date listed as January 7, 2011, and it was later archived February 7, 2011. The FOA is associated with a wide set of CFDA program areas spanning oral health, deafness and communication disorders, mental health, alcohol research, research resources, cardiovascular and lung diseases, blood diseases, arthritis and musculoskeletal/skin diseases, neuroscience and neurological disorders, allergy/immunology/transplantation, infectious diseases, general biomedical research and training, child health and human development, aging, and vision research. That broad CFDA spread reinforces the idea that non-embryonic pluripotent stem cell platforms were considered potentially relevant across many disease and physiology areas, from basic biology through translational directions. For full details, NIH referenced the full announcement page (http://grants.nih.gov/grants/guide/pa-files/PA-08-044.html) and provided NIH Office of Extramural Research (OER) webmaster contact information for access or linking issues.

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