Opportunity Information: Apply for PA 15 255
Apply for PA 15 255
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Human Studies to Evaluate Promising Medications to Treat Alcohol Use Disorder (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on May 13, 2015 and posted on May 13, 2015.
- Applicants must submit their applications by May 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: State governments For profit organizations other than small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) County governments City or township governments Public and State controlled institutions of higher education Private institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The grant opportunity "Human Studies to Evaluate Promising Medications to Treat Alcohol Use Disorder (R03)" (Funding Opportunity Number PA-15-255) is a National Institutes of Health (NIH) discretionary grant program under CFDA 93.273 (Alcohol Research Programs). Its main goal is to spur early stage, human focused research that tests promising medication candidates for alcohol use disorder (AUD), including cases where AUD occurs alongside comorbid post-traumatic stress disorder (PTSD). The emphasis is on medications that are either genuinely novel or repurposed from other indications, but in both cases the compounds should act on new biological targets relevant to AUD and/or AUD plus PTSD. In practical terms, the FOA is designed to move beyond purely preclinical work and encourage studies that can generate initial human evidence about whether these compounds are safe, tolerable, and potentially effective.
This FOA specifically encourages the use of human laboratory paradigms and/or clinical trials. Human laboratory paradigms generally refer to controlled experimental approaches in people that can measure outcomes such as craving, stress reactivity, alcohol cue responses, alcohol self-administration behavior, or other mechanistic and behavioral signals that help predict clinical benefit. Clinical trials, in turn, are intended to provide more direct tests of safety and efficacy in individuals with AUD, including those with comorbid PTSD when relevant. The overarching idea is to support smaller, targeted human studies that can help decide whether a medication is ready for larger scale testing, while also providing meaningful information about how and why it might work.
The award structure reflects that early, exploratory intent. The listed award ceiling is $50,000, consistent with an R03 mechanism that typically supports smaller projects, pilot studies, or tightly focused proof-of-concept work. The opportunity does not require cost sharing or matching funds, which can lower the barrier for institutions that might otherwise struggle to assemble matching support.
Eligibility is broad and includes a wide range of domestic and non-domestic organizations. Eligible applicants include state, county, and city or township governments; public and state controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits, excluding some higher education-related constraints as specified); small businesses and other for-profit organizations (other than small businesses); independent school districts; public housing authorities/Indian housing authorities; special district governments; and additional categories such as faith-based or community-based organizations. The FOA also lists various minority-serving and tribal-serving institutions and entities as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Tribally Controlled Colleges and Universities (TCCUs), Native American tribal governments and organizations (including those other than federally recognized), U.S. territories or possessions, regional organizations, foreign organizations (non-U.S. entities), and eligible federal agencies. This wide eligibility is intended to attract applications from many settings where clinical and translational AUD research is conducted.
Key administrative details indicate that the opportunity was posted and created on May 13, 2015, with an original and current closing date of May 7, 2018, and an archive date of June 7, 2018, meaning it is no longer open for new submissions under that announcement. The official full announcement was hosted by NIH at http://grants.nih.gov/grants/guide/pa-files/PA-15-255.html. For technical issues accessing or linking to the announcement, the listed contact point is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Taken together, PA-15-255 was aimed at accelerating the early human evaluation of medication strategies for AUD (and AUD with PTSD), prioritizing compounds that hit new targets and using experimental human lab approaches and/or clinical trials to produce actionable safety and efficacy signals that can guide future, larger studies.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Human Studies to Evaluate Promising Medications to Treat Alcohol Use Disorder (R03)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA-15-255.
Which agency offers this funding opportunity?
This is a National Institutes of Health (NIH) discretionary grant program.
What CFDA program is associated with this opportunity?
This opportunity is listed under CFDA 93.273, Alcohol Research Programs.
What is the main purpose of this FOA?
The main goal is to spur early-stage, human-focused research that tests promising medication candidates for alcohol use disorder (AUD), including situations where AUD occurs alongside comorbid post-traumatic stress disorder (PTSD).
What types of medications does the FOA prioritize?
The FOA emphasizes medications that are either genuinely novel or repurposed from other indications. In both cases, the compounds should act on new biological targets relevant to AUD and/or AUD plus PTSD.
Does the FOA support preclinical-only studies?
No. The FOA is designed to move beyond purely preclinical work and encourage studies that generate initial human evidence about whether compounds are safe, tolerable, and potentially effective.
What kinds of study designs are encouraged?
The FOA specifically encourages the use of human laboratory paradigms and/or clinical trials.
What is meant by "human laboratory paradigms" in this FOA?
Human laboratory paradigms refer to controlled experimental approaches in people that can measure outcomes such as craving, stress reactivity, alcohol cue responses, alcohol self-administration behavior, or other mechanistic and behavioral signals that help predict clinical benefit.
What is the role of clinical trials under this FOA?
Clinical trials are intended to provide more direct tests of safety and efficacy in individuals with AUD, including those with comorbid PTSD when relevant.
What is the overall research intent of the R03 structure here?
The intent is to support smaller, targeted human studies that help determine whether a medication is ready for larger-scale testing, while also providing meaningful information about how and why it might work.
What is the award ceiling for this opportunity?
The listed award ceiling is $50,000, consistent with the R03 mechanism supporting smaller projects, pilot studies, or tightly focused proof-of-concept work.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching funds.
Who is eligible to apply?
Eligibility is broad and includes a wide range of domestic and non-domestic organizations, including:
- State, county, and city or township governments
- Public and state controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits, with exclusions as specified)
- Small businesses
- Other for-profit organizations (other than small businesses)
- Independent school districts
- Public housing authorities/Indian housing authorities
- Special district governments
- Faith-based or community-based organizations
- Minority-serving and tribal-serving institutions and entities (including HBCUs, Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, and TCCUs)
- Native American tribal governments and organizations (including those other than federally recognized)
- U.S. territories or possessions
- Regional organizations
- Foreign organizations (non-U.S. entities)
- Eligible federal agencies
Are foreign (non-U.S.) organizations eligible?
Yes. Foreign organizations (non-U.S. entities) are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. The FOA lists small businesses and other for-profit organizations (other than small businesses) as eligible applicants.
Does the FOA include eligibility for minority-serving and tribal-serving institutions?
Yes. The FOA lists multiple minority-serving and tribal-serving categories, including HBCUs, Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, TCCUs, and Native American tribal governments and organizations (including those other than federally recognized).
When was this opportunity posted and created?
It was posted and created on May 13, 2015.
What was the closing date for applications under this announcement?
The original and current closing date listed is May 7, 2018.
Is this funding opportunity still open?
No. The archive date is June 7, 2018, which indicates it is no longer open for new submissions under that announcement.
Where can the full official announcement be found?
The official full announcement was hosted by NIH at: http://grants.nih.gov/grants/guide/pa-files/PA-15-255.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Does this FOA explicitly include research on AUD with comorbid PTSD?
Yes. The FOA explicitly includes interest in AUD occurring alongside comorbid PTSD and supports studies relevant to AUD plus PTSD when appropriate.
What kinds of outcomes or signals are considered useful in the early human studies described?
The FOA highlights outcomes such as craving, stress reactivity, alcohol cue responses, alcohol self-administration behavior, and other mechanistic and behavioral signals that may help predict clinical benefit.
What is the practical "next step" this FOA is trying to enable?
It aims to generate actionable early human safety, tolerability, and potential efficacy signals that can guide decisions about whether a medication should advance to larger-scale testing.
Browse more opportunities from the same category: Health
Next opportunity: 2014 Dislocated Worker National Reserve
Previous opportunity: Pennsylvania NRCS CIG 2015
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 15 255
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 15 255) also looked into and applied for these:
| Funding Opportunity |
|---|
| Human Studies to Evaluate Promising Medications to Treat Alcohol Use Disorder (R01) Apply for PA 15 256 Funding Number: PA 15 256 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| PPHF 2015 Tobacco Use Prevention Public Health Approaches for Ensuring Quitline Capacity financed solely by 2015 Prevention and Public Health Funds Apply for CDC RFA DP14 141002PPHF15 Funding Number: CDC RFA DP14 141002PPHF15 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Behavioral Interventions to Prevent HIV in Diverse Adolescent Men Who Have Sex with Men (U01) Apply for RFA MD 15 012 Funding Number: RFA MD 15 012 Agency: National Institutes of Health Category: Health Funding Amount: $1,250,000 |
| Discovery of the Genetic Basis of Structural Birth Defects and of Childhood Cancers Gabriella Miller Kids First Pediatric Research Program (X01) Apply for PAR 15 259 Funding Number: PAR 15 259 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01) Apply for PAR 15 257 Funding Number: PAR 15 257 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Protecting and Improving Public Health Globally Building and Strengthening Public Health Impact, Systems, Capacity, and Security Apply for CDC RFA GH15 1627 Funding Number: CDC RFA GH15 1627 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $10,000,000 |
| Community Capacity for Health in Madagascar Apply for RFI 687 15 002 Funding Number: RFI 687 15 002 Agency: Madagascar USAID Antananarivo Category: Health Funding Amount: $30,000,000 |
| Building Population Health Research Capacity in the U.S. Affiliated Pacific Islands (U24) Apply for RFA MD 15 011 Funding Number: RFA MD 15 011 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| Advancing Health Disparities Interventions Through Community Based Participatory Research (U01) Apply for RFA MD 15 010 Funding Number: RFA MD 15 010 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| Children s Hospitals Graduate Medical Education (CHGME) Payment Program Apply for HRSA 16 022 Funding Number: HRSA 16 022 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Immunization Information Systems (IIS) Capacity and Operations Support Apply for CDC RFA IP15 1501 Funding Number: CDC RFA IP15 1501 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,100,000 |
| Conference Grants to Advance Collaborative Research on Aging Biology (R13) Apply for PAR 15 265 Funding Number: PAR 15 265 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Zimbabwe HIV Care and Treatment (HCT) Mechanism Apply for RFA 613 15 000004 Funding Number: RFA 613 15 000004 Agency: Zimbabwe USAID Harare Category: Health Funding Amount: $35,000,000 |
| Zimbabwe Assistance Program in Malaria (ZAPIM) Apply for RFA 613 15 000005 Funding Number: RFA 613 15 000005 Agency: Zimbabwe USAID Harare Category: Health Funding Amount: $20,000,000 |
| NIMHD Transdisciplinary Collaborative Centers for Health Disparities Research Focused on Precision Medicine (U54) Apply for RFA MD 15 013 Funding Number: RFA MD 15 013 Agency: National Institutes of Health Category: Health Funding Amount: $1,500,000 |
| Viral Hepatitis Prevention and Surveillance Apply for CDC RFA PS13 13030401SUPP16 Funding Number: CDC RFA PS13 13030401SUPP16 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $500,000 |
| Planning Grants for Certified Community Behavioral Health Clinics (Short Title CCBHCs Planning Grants) Apply for SM 16 001 Funding Number: SM 16 001 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $2,000,000 |
| Human Resource for Health (HRH) Program Apply for RFA OAA 15 000021 Funding Number: RFA OAA 15 000021 Agency: Agency for International Development Category: Health Funding Amount: $145,000,000 |
| Addressing HIV Care and Housing Coordination through Data Integration to Improve Health Outcomes along the HIV Care Continuum Apply for HRSA 15 152 Funding Number: HRSA 15 152 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Annual Program Statement Integrating Community Health Apply for APS OAA 15 000004 Funding Number: APS OAA 15 000004 Agency: Agency for International Development Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 15 255", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.