Opportunity Information: Apply for RFA DK 14 025
Apply for RFA DK 14 025
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Identification of Novel Targets and Pathways Mediating Weight Loss, Diabetes Resolution and Related Metabolic Disease after Bariatric Surgery in Humans (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Aug 25, 2014 and posted on Aug 25, 2014.
- Applicants must submit their applications by Apr 16, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) County governments State governments Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
This NIH R01 funding opportunity (RFA-DK-14-025) focuses on understanding why bariatric surgery produces sustained weight loss, frequent resolution of type 2 diabetes, and broader improvements in obesity-related metabolic diseases in humans. The program is specifically aimed at studies that move beyond description and instead test mechanisms. In other words, the NIH is looking for research that identifies and directly interrogates the targets and pathways that actually drive these post-surgical outcomes, whether those targets are genuinely novel and unexplored or well-known pathways being examined in new, mechanistically rigorous ways. Applications are expected to use targeted, hypothesis-driven approaches and, ideally, modern and sophisticated methods capable of establishing causal or strongly supported mechanistic links rather than simple associations.
A key point in the scope is what will not be supported. Projects that only measure or catalog changes before versus after surgery (for example, reporting shifts in hormones, metabolites, microbiome composition, bile acids, inflammatory markers, or gene expression) without testing how those changes produce the clinical benefits are considered non-responsive. The announcement draws a firm line between observational profiling and mechanistic investigation: descriptive comparisons alone are not enough. The FOA also restricts the research to human subjects only, signaling that the scientific question here is centered on human physiology and clinical response after bariatric procedures rather than animal or cell culture models as the primary study system.
In practical grant terms, this is a discretionary grant opportunity under the NIH umbrella, using the R01 mechanism, and it falls within the Diabetes, Digestive, and Kidney Diseases research area (CFDA 93.847). The estimated total funding listed is $1.5 million, with an award ceiling of $500,000. There is no cost sharing or matching requirement. The FOA was posted August 25, 2014, with an original and current closing date of April 16, 2015, and an archive date of May 17, 2015, meaning it was a time-limited solicitation rather than an open-ended standing program announcement.
Eligibility is broad across U.S.-based organizations and institutions, spanning public and private higher education institutions, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and for-profits other than small businesses), and multiple levels of government (state, county, city/township, special district governments, and eligible tribal governments and organizations). The FOA also lists categories such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations as eligible where applicable. A notable restriction is that non-U.S. entities are not eligible to apply, and foreign components (as defined by NIH policy) are not allowed; non-domestic components of U.S. organizations are also not eligible. This keeps the work firmly within the U.S. institutional and regulatory environment for NIH-funded human subjects research.
Overall, the announcement is designed to accelerate mechanistic, human-centered research that can explain how bariatric surgery triggers durable metabolic changes, with the longer-term implication that identifying these mediators could point to new therapeutic targets that mimic surgerys benefits without surgery. The full announcement was hosted on the NIH grants site (RFA-DK-14-025), and NIH provided standard support contacts through the NIH Office of Extramural Research webmaster for access and linking issues.
Frequently Asked Questions (FAQs)
What is the goal of NIH RFA-DK-14-025?
This R01 funding opportunity is focused on explaining why bariatric surgery leads to sustained weight loss, frequent resolution of type 2 diabetes, and broader improvements in obesity-related metabolic diseases in humans. The emphasis is on identifying and testing the mechanisms that drive these outcomes, not just describing what changes after surgery.
What kind of science is NIH trying to fund under this FOA?
The FOA prioritizes targeted, hypothesis-driven, mechanistic studies in humans. Projects should directly interrogate targets and pathways that plausibly cause the post-surgical metabolic benefits, using rigorous approaches designed to establish causal (or strongly supported mechanistic) links rather than simple associations.
Does this FOA support observational or descriptive studies?
No. The FOA states that projects that only measure or catalog changes before versus after surgery are considered non-responsive if they do not test how those changes produce clinical benefits.
What are examples of non-responsive (not supported) project approaches?
Studies that only report pre- vs. post-surgery differences without mechanistic testing are not supported. The FOA gives examples such as profiling or reporting shifts in hormones, metabolites, microbiome composition, bile acids, inflammatory markers, or gene expression if the project stops at description and does not directly test their role in driving outcomes.
Are studies required to go beyond correlation?
Yes. Applications are expected to use methods and designs capable of establishing causal or strongly supported mechanistic links, rather than relying on association-only findings.
Are projects limited to human subjects research?
Yes. The FOA restricts the research to human subjects only, indicating that the scientific questions must be addressed in humans and centered on human physiology and clinical responses following bariatric procedures.
Can animal models or cell culture systems be used as the primary study system?
No. The scope is limited to human subjects only, so the primary study system must be humans as specified in the FOA.
What funding mechanism is used for this opportunity?
The opportunity uses the NIH R01 research project grant mechanism.
Which NIH research area does this FOA fall under?
It falls within the Diabetes, Digestive, and Kidney Diseases research area (CFDA 93.847).
How much total funding is estimated for this FOA?
The FOA lists an estimated total funding amount of $1.5 million.
What is the award ceiling for this opportunity?
The listed award ceiling is $500,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was this FOA posted and when did it close?
The FOA was posted on August 25, 2014. The original and current closing date is April 16, 2015.
Is this a standing program or a time-limited solicitation?
It is time-limited. The FOA includes an archive date of May 17, 2015, indicating it was not an open-ended standing announcement.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and institutions, including public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), for-profit organizations (including small businesses and for-profits other than small businesses), and multiple levels of government (state, county, city/township, special district governments), as well as eligible tribal governments and organizations.
Are minority-serving institutions and community-based organizations eligible?
Yes. The FOA lists categories such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations as eligible where applicable.
Are non-U.S. (foreign) entities eligible to apply?
No. The FOA states that non-U.S. entities are not eligible to apply.
Are foreign components allowed under NIH policy for this FOA?
No. Foreign components (as defined by NIH policy) are not allowed, and non-domestic components of U.S. organizations are also not eligible.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site under the identifier RFA-DK-14-025.
What is the broader purpose or long-term implication of this research focus?
The FOA is designed to accelerate human-centered mechanistic research that explains how bariatric surgery triggers durable metabolic changes. A longer-term implication described in the opportunity is that identifying these mediators could reveal therapeutic targets that might mimic surgery's benefits without surgery.
Who provided support contacts for access or linking issues?
NIH provided standard support contacts through the NIH Office of Extramural Research webmaster for access and linking issues.
Browse more opportunities from the same agency: National Institutes of Health
Browse more opportunities from the same category: Food and Nutrition Health
Next opportunity: Climate Change Implementation and Adaptation Measures (CLIMA Adapt)
Previous opportunity: Notice of Intent to Award funds to Utah State University
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA DK 14 025
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA DK 14 025) also looked into and applied for these:
| Funding Opportunity |
|---|
| Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01) Apply for RFA DK 14 506 Funding Number: RFA DK 14 506 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Hepatitis B Research Network Immunology Center (U01) Apply for RFA DK 14 509 Funding Number: RFA DK 14 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Hepatitis B Research Network Data Coordination Center (U01) Apply for RFA DK 14 510 Funding Number: RFA DK 14 510 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Type 1 Diabetes Complications IMPACT Award (DP3) Apply for RFA DK 14 017 Funding Number: RFA DK 14 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $2,000,000 |
| Consortium on Beta cell Death and Survival (HIRN CBDS) (UC4) Apply for RFA DK 14 021 Funding Number: RFA DK 14 021 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $900,000 |
| (Re)Building a Kidney Coordinating Center (U01) Apply for RFA DK 14 009 Funding Number: RFA DK 14 009 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $1,600,000 |
| (Re)Building a Kidney Cells to Organ (UH2/UH3) Apply for RFA DK 14 010 Funding Number: RFA DK 14 010 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Psychosocial and Behavioral Aspects of Bariatric Surgery (R01) Apply for RFA DK 14 026 Funding Number: RFA DK 14 026 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4) Apply for RFA DK 14 508 Funding Number: RFA DK 14 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Innovative Research in HIV in Kidney, Urology and Hematology (R01) Apply for RFA DK 14 020 Funding Number: RFA DK 14 020 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Elucidating HIV and HIV treatment Associated Metabolic/Endocrine Dysfunction (R01) Apply for RFA DK 14 023 Funding Number: RFA DK 14 023 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Food Specific Molecular Profiles and Biomarkers of Food and Nutrient Intake, and Dietary Exposure (R01) Apply for PAR 15 024 Funding Number: PAR 15 024 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Administrative Supplements for Human Islet Research (Admin Supp) Apply for PA 15 025 Funding Number: PA 15 025 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $100,000 |
| Research on Eosinophil Associated Disorders (R01) Apply for PA 15 027 Funding Number: PA 15 027 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Research on Eosinophil Associated Disorders (R21) Apply for PA 15 028 Funding Number: PA 15 028 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $275,000 |
| Underactive Bladder in Aging (R01) Apply for PA 15 049 Funding Number: PA 15 049 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| USAID Child Blindness Program Apply for PGRD 14 0002 Funding Number: PGRD 14 0002 Agency: Agency for International Development Category: Food and Nutrition Health Funding Amount: $250,000 |
| Developmental Centers for Interdisciplinary Research in Benign Urology (P20) Apply for RFA DK 15 001 Funding Number: RFA DK 15 001 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| George M. OBrien Urology Cooperative Research Centers Program (U54) Apply for RFA DK 15 002 Funding Number: RFA DK 15 002 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $1,000,000 |
| NIDDK Multi Center Clinical Study Cooperative Agreement (U01) Apply for PAR 15 067 Funding Number: PAR 15 067 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA DK 14 025", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.