Opportunity Information: Apply for PAR 12 043
Apply for PAR 12 043
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Identifying Heart, Lung, and Blood Disease Causing Variants (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jan 20, 2012 and posted on Nov 30, 2011.
- Applicants must submit their applications by Jan 20, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,515,000.00 to eligible and selected applicants.
- Eligible applicants include: Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses For profit organizations other than small businesses Special district governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Independent school districts Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Identifying Heart, Lung, and Blood Disease Causing Variants (R01)" (Funding Opportunity Number PAR-12-043) is an NIH discretionary research grant aimed at pushing forward the discovery of rare genetic variants that contribute to diseases affecting the heart, lungs, and blood. The central purpose is to stimulate research that makes strong use of large-scale exome sequencing resources that were generated through major federal and consortium efforts, especially the American Recovery and Reinvestment Act of 2009 (ARRA) Grand Opportunity (GO) Exome Sequencing Project (GO ESP), CHARGE Sequencing (CHARGE S), and other related genomic datasets. In practical terms, the program is designed to encourage investigators to mine these rich exome datasets to pinpoint disease-causing or disease-associated rare variants, with the expectation that the resulting findings will deepen biological understanding and potentially improve risk prediction, diagnosis, or future therapeutic directions for heart, lung, and blood conditions.
This funding is offered through the R01 mechanism, which generally supports hypothesis-driven, investigator-initiated research projects of substantial scope. Because the announcement highlights the availability of extensive exome data, the scientific emphasis is on leveraging existing sequencing and genomic resources rather than generating small, disconnected datasets. Projects responsive to this opportunity would be expected to take advantage of the depth and breadth of the provided exome data to identify rare coding variants, evaluate their relationship to relevant phenotypes, and apply appropriate statistical genetics and functional interpretation approaches to separate true disease signals from noise. The overall theme is variant discovery and prioritization in clinically relevant domains tied to cardiovascular disease, lung disease, blood diseases and resources, and sleep disorders research, as reflected in the CFDA numbers listed (93.233, 93.837, 93.838, 93.839).
Administratively, the opportunity is categorized as a grant in the health funding activity area and does not require cost sharing or matching funds, which reduces barriers for applicants that may not have discretionary funds to contribute. The total estimated funding amount listed is $1,515,000, indicating a defined pool to support meritorious projects under this announcement. Key dates included a posted date of November 30, 2011, with creation on January 20, 2012, an original closing date of February 8, 2013, a current closing date of January 20, 2012, and an archive date of February 20, 2012. These dates indicate the announcement is now archived, but the details remain useful as a reference for the structure and intent of the initiative and for understanding how NIH framed rare-variant discovery priorities around those major exome resources.
Eligibility is broad across U.S.-based organizational types, reflecting NIH's intent to attract a wide research community. Eligible applicants include public and private institutions of higher education, state and local governments, tribal organizations (including federally recognized tribal governments and other tribal entities), nonprofits both with and without 501(c)(3) status, and for-profit organizations including small businesses. The eligibility language also explicitly includes several categories of institutions and organizations often highlighted in NIH programs, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions, as well as eligible agencies of the federal government. At the same time, the announcement clearly restricts non-U.S. entities: foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible. However, foreign components are allowed as defined by NIH policy, meaning a U.S. applicant could incorporate certain international elements if they meet NIH's definition and requirements for a foreign component.
The sponsoring agency is the National Institutes of Health, and the announcement directs applicants to the full FOA page for complete details. For technical issues accessing or linking to the announcement, the provided point of contact is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV). Overall, this opportunity is best understood as an NIH effort to convert high-value, already-generated exome sequencing datasets into actionable discoveries about rare coding variants that influence heart, lung, and blood diseases, by supporting robust R01-level analyses and associated validation and interpretation work within eligible U.S.-based applicant organizations.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Identifying Heart, Lung, and Blood Disease Causing Variants (R01)" and the Funding Opportunity Number is PAR-12-043.
Which agency is sponsoring this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What is the main purpose of PAR-12-043?
The central purpose is to stimulate research that identifies rare genetic variants that cause or are associated with diseases affecting the heart, lungs, and blood. The emphasis is on using large-scale exome sequencing resources that have already been generated through major federal and consortium efforts.
What types of scientific activities does this opportunity emphasize?
This opportunity emphasizes mining large, existing exome sequencing datasets to pinpoint rare coding variants, evaluating their relationship to relevant phenotypes, and using appropriate statistical genetics and functional interpretation approaches to distinguish true disease signals from background noise.
Which major exome sequencing resources are specifically highlighted?
The announcement highlights the American Recovery and Reinvestment Act of 2009 (ARRA) Grand Opportunity (GO) Exome Sequencing Project (GO ESP), CHARGE Sequencing (CHARGE S), and other related genomic datasets.
Is this grant intended for generating new sequencing datasets or using existing ones?
The scientific emphasis is on leveraging existing large-scale exome sequencing and genomic resources rather than generating small, disconnected datasets. Responsive projects would be expected to take advantage of the depth and breadth of the available exome data resources referenced in the announcement.
What funding mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which generally supports hypothesis-driven, investigator-initiated research projects of substantial scope.
What disease or research areas are included under this opportunity?
The opportunity focuses on diseases and conditions affecting the heart, lung, and blood, and it also references sleep disorders research as part of the clinically relevant domains tied to the listed CFDA numbers.
What CFDA numbers are associated with this opportunity?
The CFDA numbers listed are 93.233, 93.837, 93.838, 93.839.
Does this grant require cost sharing or matching funds?
No. The opportunity states that cost sharing or matching funds are not required.
What is the total estimated funding amount for this opportunity?
The total estimated funding amount listed is $1,515,000.
What is the funding activity area for this opportunity?
The opportunity is categorized as a grant in the health funding activity area.
Is this funding opportunity still open?
No. The dates provided indicate the announcement is archived. It shows an archive date of February 20, 2012, and includes historical closing dates (including an original closing date of February 8, 2013, and a current closing date of January 20, 2012 as listed in the provided information).
What are the key dates listed for this opportunity?
Key dates included a posted date of November 30, 2011; creation on January 20, 2012; an original closing date of February 8, 2013; a current closing date of January 20, 2012; and an archive date of February 20, 2012.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizational types, including public and private institutions of higher education; state and local governments; tribal organizations (including federally recognized tribal governments and other tribal entities); nonprofits with and without 501(c)(3) status; and for-profit organizations including small businesses.
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The eligibility language explicitly includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Can federal government agencies apply?
Yes. The eligibility description includes eligible agencies of the federal government.
Are foreign institutions eligible to apply directly?
No. The announcement restricts non-U.S. entities: foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible.
Are any international elements allowed in a project?
Yes. Foreign components are allowed as defined by NIH policy, meaning a U.S. applicant could incorporate certain international elements if they meet NIH's definition and requirements for a foreign component.
What is the intended impact of the research supported by this opportunity?
The expectation is that resulting findings will deepen biological understanding and may improve risk prediction, diagnosis, or inform future therapeutic directions for heart, lung, and blood conditions.
Where should applicants look for complete details?
The announcement directs applicants to the full Funding Opportunity Announcement (FOA) page for complete details.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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