Image Guided Cancer Interventions (STTR R41/R42) | Apply Online

Opportunity Summary:

The Image Guided Cancer Interventions (STTR R41/R42) opportunity (Funding Opportunity Number PA-07-041) is a National Institutes of Health (NIH) discretionary grant program designed to push forward practical, clinically tested technologies that use medical imaging to guide cancer treatment. The central focus is on image guided interventions (IGIs), meaning systems that combine imaging with real-time monitoring and therapeutic action so clinicians can better target tumors, track what is happening during a procedure, and adjust treatment on the spot. The overall intent is not just to fund isolated components or early concepts, but to support the creation and refinement of fully integrated end-to-end systems and to generate the evidence needed to show these systems work in real clinical settings.

A major emphasis of the FOA is clinical validation. Projects are expected to move beyond bench development into clinical evaluation, where appropriate, to demonstrate performance, workflow fit, and potential impact on cancer care. Because meaningful clinical validation often requires more than one site or more than one device build, the FOA also highlights the need to develop multiple prototype integrated IGI systems when multisite testing demands it. In practice, this means the program is aimed at technologies that are mature enough to be engineered into working prototypes and then evaluated in clinical environments, rather than remaining at the level of simulations or stand-alone tools.

The funding mechanism is the Small Business Technology Transfer (STTR) program using the R41 (Phase I) and R42 (Phase II) award structure, with the option for Fast Track applications that propose a seamless Phase I-to-Phase II path. STTR is specifically intended to support research partnerships between small businesses and nonprofit research institutions such as universities, medical schools, and clinical centers, which aligns with the FOA's stated goal of encouraging collaborations among small business, large business, and academic clinical partners, as well as small business joint ventures. The announcement also notes that it runs in parallel with a scientifically similar opportunity under the SBIR program (PA-07-042, using R43/R44), which is relevant for applicants deciding whether their project and partnership model fit better under STTR or SBIR rules.

In terms of budget and project period, the FOA follows the SF424 (R&R) SBIR/STTR Application Guide and statutory guidelines, but it also states specific caps for this program. For Phase I, applicants may request up to $150,000 in total costs per year for up to two years. For Phase II, applicants may request up to three years of support at up to $1,000,000 in total costs per year when the Phase II research includes clinical evaluation. If Phase II work does not include clinical evaluation, the limit is lower, capped at $750,000 in total costs per year. These ceilings signal that NIH expects Phase II projects involving clinical studies to require substantially more resources than engineering-only development.

Eligibility is oriented toward small businesses, consistent with STTR requirements, with additional eligibility details referenced in the full announcement. A clear restriction is that foreign institutions are not eligible to apply. The opportunity does not require cost sharing or matching. The program is listed under the health and education activity area and is associated with CFDA number 93.394 (Cancer Detection and Diagnosis Research), reflecting its connection to cancer imaging and intervention research priorities.

Administratively, the FOA was posted on November 8, 2006, and uses multiple receipt dates (rather than a single deadline), with exact due dates provided in the full announcement. The archived date noted is October 2, 2009, which matters for historical context and for understanding whether an applicant should instead look for a current successor FOA if seeking active funding today. The full announcement is linked through NIH at http://grants.nih.gov/grants/guide/pa-files/PA-07-041.html, and NIH provides contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.

In plain terms, this grant opportunity is aimed at small business-led teams that can partner effectively with research and clinical institutions to build integrated imaging-plus-therapy systems for cancer, prove they work in real clinical environments, and take concrete steps toward broader, multisite evaluation and eventual adoption in clinical practice.

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