Opportunity Information: Apply for PA 12 193
Apply for PA 12 193
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) STTR R41/R42" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Jun 4, 2012 and posted on Jun 4, 2012.
- Applicants must submit their applications by Apr 5, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The grant opportunity "Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) STTR R41/R42" (Funding Opportunity Number PA-12-193) is a National Institutes of Health (NIH) Small Business Technology Transfer (STTR) program solicitation aimed at pushing better dental imaging diagnostics from advanced development into real clinical use. The core goal is to support small business-led projects, done in partnership with a research institution as required under STTR, that can produce diagnostic devices and methods that are reliable and reproducible while also being highly specific and highly sensitive for detecting major dental diseases and conditions. The clinical targets called out are dental caries, periodontal disease, cracked teeth, and assessment of pulp vitality, which are areas where current chairside approaches often fall short in early detection, objectivity, or consistency across clinicians and settings.
A central requirement of the opportunity is that proposed technologies must show clear performance advantages over standard-of-care diagnostic methods, especially the common visual, tactile, and radiographic exam approach used for caries detection. In practical terms, applicants are expected to demonstrate that their tool can identify disease more accurately (higher sensitivity) while also reducing false positives (higher specificity) compared to what clinicians can typically achieve with existing methods. Just as important, the solicitation emphasizes that improved diagnostic performance cannot come at the cost of increased health risk to patients, meaning applicants should pay close attention to safety, exposure considerations, and overall risk profile when proposing imaging hardware, software, or combined systems.
The announcement is intentionally broad about the kinds of imaging and sensing approaches that may be supported, and it explicitly encourages both refinement of promising existing modalities and the invention of novel ones. Example approaches mentioned include optical coherence tomography (OCT), either alone or paired with Raman spectroscopy, as well as MRI image analysis. It also points to techniques based on tissue properties and energy interactions such as electrical conductivity measurement (ECM), alternating current impedance spectroscopy, quantitative laser fluorescence (QLF), multiphoton imaging, infrared thermography, infrared fluorescence, ultrasound, and terahertz imaging. The inclusion of such a wide range of modalities signals that NIH is looking for solutions that can work across different diagnostic challenges, such as detecting subsurface demineralization in early caries, identifying periodontal tissue changes, locating and characterizing cracks that may be difficult to see on conventional radiographs, and evaluating whether the dental pulp is vital in a way that is more objective than traditional tests.
From a program-design perspective, this is a discretionary grant under the STTR mechanism, using the R41/R42 phased structure. That structure is intended to support a pathway from early-stage feasibility and prototype development (Phase I, R41) into more advanced development, validation, and steps toward commercialization and clinical implementation (Phase II, R42). The overall emphasis on "advanced development and clinical implementation" indicates that projects should be more than purely exploratory research; competitive applications typically align with device development milestones, validation plans, usability and workflow considerations, and evidence-generation strategies that can reasonably lead to adoption in real dental settings.
Administratively, the opportunity falls under CFDA 93.121 (Oral Diseases and Disorders Research). It does not require cost sharing or matching funds. Eligibility is limited to small businesses, consistent with STTR requirements, and the sponsoring agency is NIH. The opportunity was posted on June 4, 2012, with an original and final closing date of April 5, 2015, and it was archived on May 6, 2015, meaning it is no longer open for new submissions under that specific announcement. For full details, NIH referenced the archived funding announcement page (http://grants.nih.gov/grants/guide/pa-files/PA-12-193.html). For access or technical issues with the electronic announcement, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) STTR R41/R42 (PA-12-193)
What is this grant opportunity?
This funding opportunity is an NIH Small Business Technology Transfer (STTR) program solicitation titled "Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) STTR R41/R42" (Funding Opportunity Number PA-12-193). It is designed to move improved dental imaging diagnostics from advanced development toward real clinical use.
What is the main purpose of the program?
The core goal is to support small business-led projects (in partnership with a research institution, as required under STTR) that can produce diagnostic devices and methods that are reliable and reproducible, and that are highly specific and highly sensitive for detecting major dental diseases and conditions.
Which dental diseases and conditions are specifically targeted?
The announcement calls out four clinical targets: dental caries, periodontal disease, cracked teeth, and assessment of pulp vitality.
Why are these diagnostic targets emphasized?
These are areas where common chairside diagnostic approaches can fall short in early detection, objectivity, or consistency across clinicians and settings.
Who is eligible to apply?
Eligibility is limited to small businesses, consistent with STTR requirements.
Does the project have to involve a research institution partner?
Yes. The opportunity is under the STTR mechanism, which requires a partnership between the small business and a research institution.
What funding mechanism and phases does this opportunity use?
This opportunity uses the STTR R41/R42 phased structure: Phase I (R41) supports feasibility and prototype development, and Phase II (R42) supports advanced development, validation, and steps toward commercialization and clinical implementation.
Is this opportunity intended for basic exploratory research?
The emphasis on "advanced development and clinical implementation" indicates that projects are expected to go beyond purely exploratory research and align with development milestones, validation plans, workflow considerations, and evidence-generation strategies that can lead to adoption in real dental settings.
What performance expectations are stated for proposed diagnostic technologies?
Proposed technologies must show clear performance advantages over standard-of-care diagnostic methods. In particular, applicants are expected to demonstrate improved diagnostic accuracy, including higher sensitivity (better detection) and higher specificity (fewer false positives) compared with typical existing approaches.
What standard-of-care comparison is specifically mentioned?
The solicitation specifically highlights comparison to the common visual, tactile, and radiographic exam approach used for caries detection.
Does the opportunity address patient safety and risk?
Yes. The solicitation emphasizes that improved diagnostic performance should not come at the cost of increased health risk to patients. Applicants are expected to pay attention to safety, exposure considerations, and the overall risk profile of imaging hardware, software, or combined systems.
What kinds of imaging or sensing technologies are within scope?
The announcement is broad and encourages both refinement of promising existing modalities and the invention of novel ones. Example approaches mentioned include optical coherence tomography (OCT) (alone or paired with Raman spectroscopy), MRI image analysis, and techniques based on tissue properties and energy interactions.
Can you list specific example modalities mentioned in the announcement?
Examples cited include optical coherence tomography (OCT), OCT paired with Raman spectroscopy, MRI image analysis, electrical conductivity measurement (ECM), alternating current impedance spectroscopy, quantitative laser fluorescence (QLF), multiphoton imaging, infrared thermography, infrared fluorescence, ultrasound, and terahertz imaging.
What diagnostic challenges is NIH looking to address with these modalities?
The wide range of modalities signals interest in solutions that can address different clinical needs, such as detecting subsurface demineralization in early caries, identifying periodontal tissue changes, locating and characterizing cracks that may be difficult to see on conventional radiographs, and evaluating pulp vitality in a more objective way than traditional tests.
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching funds.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What CFDA program is associated with this funding opportunity?
The opportunity is listed under CFDA 93.121 (Oral Diseases and Disorders Research).
When was this opportunity posted and when did it close?
It was posted on June 4, 2012. The original and final closing date was April 5, 2015.
Is this funding opportunity still open?
No. The announcement was archived on May 6, 2015, which means it is no longer open for new submissions under this specific announcement.
Where can someone find the full archived funding announcement?
NIH referenced the archived funding announcement page at: http://grants.nih.gov/grants/guide/pa-files/PA-12-193.html
Who should be contacted for access or technical issues with the electronic announcement?
The listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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Previous opportunity: Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) SBIR R43/R44
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