Opportunity Information: Apply for RFA AG 15 018
Apply for RFA AG 15 018
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Immune and Inflammatory Mechanisms in Alzheimers Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 1, 2014 and posted on Aug 1, 2014.
- Applicants must submit their applications by Jan 29, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education For profit organizations other than small businesses County governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Independent school districts City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Immune and Inflammatory Mechanisms in Alzheimers Disease (R01) (RFA-AG-15-018) is a National Institutes of Health funding opportunity focused on clarifying how immune and inflammatory biology contributes to the development and progression of Alzheimers disease. The central aim is to define the roles of the brain innate immune system and the systemic (peripheral) immune system, and especially how communication between the two changes with aging. The announcement emphasizes that Alzheimers is not only a neurodegenerative disorder in neurons, but also involves complex immune signaling and inflammatory pathways that may shape disease onset, trajectory, and heterogeneity across individuals. Projects are expected to generate stronger mechanistic evidence about which immune cells, signaling pathways, and inflammatory mediators are causal or disease-modifying, rather than merely correlated with pathology.
A key theme is crosstalk between the central nervous system and the periphery. The opportunity highlights the need to understand how age-related alterations in immune function influence brain health, including how systemic inflammation, immune cell trafficking, blood-brain barrier changes, and signaling molecules circulating in blood might affect microglia and other brain-resident immune cells. The FOA also points to the importance of identifying networks of interacting cell types across compartments (brain and body) and the mediators that connect them. In practice, that could include mapping how microglia, astrocytes, endothelial cells, peripheral myeloid cells, lymphocytes, and cytokine or complement pathways interact over time, and how those interactions may differ by disease stage, genetic background, or environmental exposures.
The NIH is signaling that it wants interdisciplinary and integrative research strategies rather than narrow, single-factor studies. Competitive applications would typically bring together expertise across immunology, neuroscience, aging biology, systems biology, and computational or network-based analysis. The stated expectation is that integrative approaches will reveal etiological mechanisms, meaning underlying causal pathways that help explain why Alzheimers emerges and progresses, and potentially identify points of intervention. While the announcement text does not prescribe specific methods, the emphasis on cell networks and mediators strongly aligns with approaches that can connect multi-level data (cell states, signaling pathways, and organism-level immune changes) into coherent mechanistic models.
From an administrative standpoint, this is a discretionary NIH research grant using the R01 mechanism, categorized under health and listed under CFDA 93.866 (Aging Research). The opportunity was posted on August 1, 2014, with an application due date of January 29, 2015, and it was archived March 1, 2015. The estimated total program funding was $4,000,000, and the award ceiling listed is $500,000, indicating an upper limit on the amount that can be requested or awarded per project under this call (as stated in the listing). There is no cost sharing or matching requirement, which is typical for NIH R01 awards.
Eligibility is broad and includes many types of applicant organizations. Eligible entities include public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit structures), for-profit organizations other than small businesses, small businesses, and multiple levels of government (state, county, city/township, special district governments), as well as public housing authorities/Indian housing authorities and independent school districts. The FOA also explicitly includes a wide range of institutions serving underrepresented communities, such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs, along with faith-based and community-based organizations where appropriate. Importantly, non-U.S. entities are eligible: foreign organizations and foreign institutions can apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.
For support and access issues, the listing provides NIH Office of Extramural Research (OER) webmaster contacts for technical difficulties accessing the announcement or resolving linking problems. The full announcement was hosted on the NIH grants site under the RFA link provided in the source data.
FAQs: Immune and Inflammatory Mechanisms in Alzheimers Disease (R01) (RFA-AG-15-018)
What is this funding opportunity about?
This NIH opportunity supports research to clarify how immune and inflammatory biology contributes to the development and progression of Alzheimers disease, with a focus on generating mechanistic (causal) evidence rather than simple correlations.
What is the central scientific aim of the announcement?
The central aim is to define the roles of the brain innate immune system and the systemic (peripheral) immune system, and to understand how communication between the two changes with aging.
Why does the FOA emphasize immune and inflammatory pathways in Alzheimers?
The announcement frames Alzheimers as more than a neuron-only neurodegenerative disorder. It highlights complex immune signaling and inflammatory pathways that may influence disease onset, disease course (trajectory), and differences across individuals (heterogeneity).
What type of evidence is NIH expecting from proposed projects?
Projects are expected to produce stronger mechanistic evidence about which immune cells, signaling pathways, and inflammatory mediators are causal or disease-modifying, rather than findings that are merely associated with pathology.
What does the FOA mean by crosstalk between the brain and the periphery?
It refers to two-way communication between the central nervous system and the systemic immune system, including how signals and immune activities in the body can influence brain-resident immune cells and brain health, particularly in the context of aging.
What aging-related immune changes are highlighted as important?
The opportunity highlights age-related alterations in immune function and how they may affect the brain, including systemic inflammation, immune cell trafficking, blood-brain barrier changes, and circulating signaling molecules in blood that may influence microglia and other brain-resident immune cells.
What kinds of cell types and compartments does NIH want applicants to consider?
The FOA points to networks of interacting cell types across brain and body compartments. Examples mentioned include microglia, astrocytes, endothelial cells, peripheral myeloid cells, lymphocytes, and pathways involving cytokines or complement.
Does the opportunity focus on single factors or integrated mechanisms?
It emphasizes interdisciplinary and integrative research strategies rather than narrow, single-factor studies, with an interest in network-level interactions and mediators that connect systems over time.
Are certain approaches implied as a good fit, even if not required?
While specific methods are not prescribed, the emphasis on interacting cell networks and connecting mediators aligns with strategies that integrate multi-level data (for example, cell states, signaling pathways, and organism-level immune changes) into coherent mechanistic models.
Does the FOA mention differences by disease stage or other modifiers?
Yes. It notes that interactions among immune and inflammatory components may differ by disease stage, genetic background, or environmental exposures.
What grant mechanism is used for this opportunity?
This is a discretionary NIH research grant using the R01 mechanism.
What is the CFDA number and category?
The listing identifies CFDA 93.866 and categorizes it under Aging Research (health).
What are the key dates for this opportunity?
The opportunity was posted on August 1, 2014. The application due date listed is January 29, 2015. It was archived on March 1, 2015.
Is this opportunity still open?
Based on the information provided, it was archived on March 1, 2015, which indicates it is no longer an active open call in that listing.
How much total funding was estimated for the program?
The estimated total program funding was $4,000,000.
What is the award ceiling for an individual project?
The listing shows an award ceiling of $500,000, indicating an upper limit on the amount that can be requested or awarded per project under this call (as stated in the listing).
Is cost sharing or matching required?
No. The listing states there is no cost sharing or matching requirement, which is typical for NIH R01 awards.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofits (including 501(c)(3) and other nonprofit structures); for-profit organizations other than small businesses; small businesses; and multiple levels of government (state, county, city/township, and special district governments), as well as public housing authorities/Indian housing authorities and independent school districts.
Are minority-serving and underrepresented-community institutions included?
Yes. The FOA explicitly includes institutions serving underrepresented communities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs. It also notes faith-based and community-based organizations where appropriate.
Can foreign organizations apply?
Yes. The listing explicitly states that foreign organizations and foreign institutions can apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.
Where can applicants get help with access or technical issues?
The listing provides NIH Office of Extramural Research (OER) webmaster contacts for technical difficulties accessing the announcement or resolving linking problems, and notes the full announcement was hosted on the NIH grants site under the RFA link.
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