Opportunity Information: Apply for RFA HD 12 206
Apply for RFA HD 12 206
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Improving Adherence to Treatment Regimens for HIV Positive Adolescents and Young Adults (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 28, 2011 and posted on Oct 28, 2011.
- Applicants must submit their applications by Feb 21, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education County governments Independent school districts City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This NIH grant opportunity (RFA-HD-12-206) supports R01 research projects focused on improving how well HIV-positive adolescents and young adults stick with their treatment plans. The target populations are adolescents ages 11 to 21 and young adults ages 21 to 24. The central aim is to spur the creation, adaptation, testing, and evaluation of interventions that increase adherence to medical regimens (such as taking antiretroviral therapy on schedule, keeping clinic appointments, monitoring labs, and following care plans) and/or behavioral regimens (such as risk-reduction behaviors, substance use-related behavior change, or other health-protective routines tied to HIV care and outcomes). The emphasis is not only on trying out existing approaches, but on developing new strategies or meaningfully adapting established ones so they fit the real-world needs, developmental stages, and environments of youth living with HIV.
A key feature of the announcement is its openness to studying the full range of factors that shape adherence for these age groups. Applicants are encouraged to examine influences at multiple levels, including individual factors (motivation, mental health, cognition, stigma experiences, health literacy, self-efficacy), family factors (caregiver involvement, household stability, communication, support, conflict), social and peer factors (relationships, disclosure dynamics, school and community context), and broader structural or contextual issues (poverty, housing instability, transportation, access to youth-friendly care, policy barriers, discrimination, criminalization, and other political or systemic conditions that can make adherence harder). The FOA signals that strong projects may connect these influences to intervention design, rather than treating adherence as only a matter of personal choice or willpower.
The opportunity also highlights measurement as an important area of innovation. Projects may include developing new adherence measures or refining existing ones while building and testing interventions. This reflects a practical challenge in HIV care research: adherence is difficult to measure accurately, especially for adolescents and young adults whose routines, privacy concerns, and living situations vary widely. Work under this FOA can therefore include improving measurement approaches that better capture real adherence behavior and the mechanisms that interventions are meant to change, which in turn strengthens the evaluation of whether an intervention is truly efficacious (works under controlled conditions) or effective (works in real-world settings).
From a funding and administrative standpoint, this is a discretionary grant opportunity using the NIH R01 mechanism. The estimated total funding listed is $2,500,000, with an award ceiling of $400,000. The posting and creation date were October 28, 2011, with a closing date of February 21, 2012, and an archive date of March 23, 2012. The announcement indicates no cost sharing or matching requirement, meaning applicants are not required to provide matching funds as a condition of the award.
Eligibility is broad and includes many organization types across the public and private sectors. Eligible applicants include nonprofit organizations (including those with 501(c)(3) status and certain nonprofits without 501(c)(3)), for-profit organizations other than small businesses, small businesses, institutions of higher education (public, private, and state-controlled), state and local governments (including county and city/township governments), independent school districts, special district governments, public housing authorities and Indian housing authorities, and tribal governments and tribal organizations (including federally recognized tribal governments and other Indian/Native American tribal governments). The FOA also explicitly includes a range of mission-focused institution types and community-rooted organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed consistent with the NIH Grants Policy Statement.
Overall, the grant is designed to move the field toward better, developmentally appropriate, and context-sensitive ways to help HIV-positive adolescents and young adults maintain consistent engagement with treatment and prevention-related behaviors. By supporting intervention development and rigorous evaluation, alongside attention to multilevel drivers of adherence and improved measurement, the FOA aims to generate practical evidence that can translate into stronger health outcomes for youth living with HIV and more reliable models for clinics, communities, and health systems to implement.
Frequently Asked Questions (FAQs)
What is the NIH funding opportunity being described?
This is an NIH grant opportunity announcement identified as RFA-HD-12-206. It supports R01 research projects focused on improving adherence to treatment and care plans among HIV-positive adolescents and young adults.
What is the main goal of this grant?
The central aim is to spur the creation, adaptation, testing, and evaluation of interventions that increase adherence to HIV-related medical and behavioral regimens for youth living with HIV, with strong attention to real-world fit and developmental appropriateness.
Which age groups are targeted by this FOA?
The target populations are HIV-positive adolescents ages 11 to 21 and young adults ages 21 to 24.
What kinds of adherence does the FOA focus on?
The FOA covers both medical regimen adherence and behavioral regimen adherence. Medical adherence examples include taking antiretroviral therapy (ART) on schedule, keeping clinic appointments, monitoring labs, and following care plans. Behavioral adherence examples include risk-reduction behaviors, substance use-related behavior change, and other health-protective routines tied to HIV care and outcomes.
Does the FOA support creating new interventions, or only testing existing ones?
It supports both. The announcement emphasizes not only trying existing approaches, but also developing new strategies or meaningfully adapting established ones so they fit the developmental stages, environments, and real-world needs of adolescents and young adults living with HIV.
What does the FOA mean by "meaningfully adapting" an intervention?
Based on the description provided, adaptation is encouraged when it improves fit for youth living with HIV, taking into account developmental stage and real-world settings. The FOA signals interest in approaches that are tailored to the lived environments and practical constraints youth experience, rather than minor or cosmetic changes.
What types of factors are applicants encouraged to study as influences on adherence?
Applicants are encouraged to examine a full range of influences at multiple levels, including individual factors (motivation, mental health, cognition, stigma experiences, health literacy, self-efficacy), family factors (caregiver involvement, household stability, communication, support, conflict), social and peer factors (relationships, disclosure dynamics, school and community context), and broader structural or contextual issues (poverty, housing instability, transportation, access to youth-friendly care, policy barriers, discrimination, criminalization, and other political or systemic conditions).
Is the FOA limited to individual-level behavior change approaches?
No. The FOA is explicitly open to multilevel perspectives and encourages projects that connect individual, family, social, and structural/contextual drivers to intervention design rather than framing adherence only as a matter of personal choice or willpower.
Are structural barriers like housing and transportation considered relevant in this FOA?
Yes. The FOA specifically mentions structural and contextual issues such as poverty, housing instability, transportation barriers, access to youth-friendly care, and policy barriers as potential influences on adherence that applicants may study and address.
Does the opportunity encourage work on adherence measurement?
Yes. Measurement is highlighted as an important area of innovation. Projects may include developing new adherence measures or refining existing measures while building and testing interventions.
Why does the FOA emphasize adherence measurement?
The description notes that adherence can be difficult to measure accurately, especially for adolescents and young adults whose routines, privacy concerns, and living situations vary widely. Improving measurement can help better capture actual adherence behaviors and the mechanisms an intervention is intended to change, strengthening evaluation of intervention efficacy and effectiveness.
Does the FOA distinguish between efficacy and effectiveness?
Yes. It references evaluating whether an intervention is efficacious (works under controlled conditions) or effective (works in real-world settings), and frames improved measurement as a way to strengthen those evaluations.
What grant mechanism is used for this opportunity?
This is a discretionary NIH grant opportunity using the NIH R01 mechanism.
How much funding is available under this FOA?
The estimated total funding listed is $2,500,000, and the award ceiling is $400,000.
Is there a cost sharing or matching requirement?
No. The announcement indicates there is no cost sharing or matching requirement, meaning applicants are not required to provide matching funds as a condition of the award.
When was this FOA posted, and what were the key dates?
The posting and creation date were October 28, 2011. The closing date was February 21, 2012. The archive date was March 23, 2012.
What types of organizations are eligible to apply?
Eligibility is broad and includes nonprofit organizations (including 501(c)(3) and certain nonprofits without 501(c)(3)), for-profit organizations other than small businesses, small businesses, institutions of higher education (public, private, and state-controlled), and state and local governments (including county and city/township governments). It also includes independent school districts, special district governments, public housing authorities and Indian housing authorities, and tribal governments and tribal organizations.
Are community-based and faith-based organizations eligible?
Yes. The FOA explicitly includes faith-based and community-based organizations among eligible applicants.
Are minority-serving institutions specifically included as eligible applicants?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions among eligible applicants.
Can foreign institutions apply?
Yes. Foreign institutions are eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. The FOA states that non-U.S. components of U.S. organizations are eligible.
Are foreign components allowed on applications?
Yes. Foreign components are allowed, consistent with the NIH Grants Policy Statement.
What is the overall intent of the FOA for the field?
The grant is designed to move the field toward better, developmentally appropriate, context-sensitive approaches that help HIV-positive adolescents and young adults maintain consistent engagement with treatment and prevention-related behaviors. It emphasizes intervention development and rigorous evaluation, attention to multilevel drivers of adherence, and improved measurement to generate practical evidence for clinics, communities, and health systems.
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