Improving Heart Failure Disease Management (R01) | Apply Online

Opportunity Summary:

Improving Heart Failure Disease Management (R01) (Funding Opportunity Number PA 07 355) is a National Institutes of Health (NIH) research grant opportunity aimed at pushing the field of chronic heart failure care beyond what is currently known and routinely practiced. The core intent is to stimulate innovative, rigorous studies that tackle important, still-unresolved questions about how heart failure disease management is delivered in real clinical settings. The broader public health goal is practical and outcomes-driven: identify disease management approaches that truly work, refine and strengthen existing tools, and then improve how those tools are implemented and disseminated so they are used consistently in everyday care. Ultimately, the program is focused on reducing heart failure-related illness and deaths while measurably improving patient outcomes.

The opportunity uses the NIH Research Project Grant (R01) mechanism, which is designed for substantial, hypothesis-driven research projects that can generate strong evidence and generalizable findings. At the same time, NIH signals that not every idea belongs in an R01; applicants whose projects are better matched to other mechanisms such as R18, R21, or SBIR/STTR are encouraged to use those alternative pathways. This is essentially a fit-and-scope reminder: the expectation is that R01 proposals will be appropriately sized, methodologically robust, and capable of producing meaningful advances in heart failure disease management.

Funding levels and the number of awards are not preset, because NIH expects proposals to vary widely in design, scope, and cost. As a result, award size and project duration may differ from one funded application to another. The total amount awarded and the number of grants made will depend on the volume of applications received, their scientific and technical quality, the requested budgets and timelines, and the availability of funds. The announcement is structured around multiple receipt dates rather than a single deadline, meaning applications can be submitted according to NIH’s recurring submission cycles (with the specific dates provided in the full announcement).

Eligibility is broad and includes many types of domestic and international applicants. Eligible organizations include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), state and local governments (including city/township, county, and special district governments), independent school districts, public housing authorities/Indian housing authorities, Native American tribal governments and other tribal organizations, small businesses, and for-profit organizations (including entities other than small businesses). The announcement also specifies that foreign institutions may apply, eligible federal agencies may apply, and faith-based or community-based organizations are not excluded. There is no cost-sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of award.

From a topic standpoint, the focus is chronic heart failure disease management in clinical practice, with an emphasis on the real-world performance of tools and strategies intended to improve care. While the brief synopsis does not list specific research topics, the language clearly points toward implementation and effectiveness concerns: how disease management programs, care pathways, monitoring approaches, education/support interventions, and other management tools can be optimized, adopted more reliably, and spread across care settings. The emphasis on reducing morbidity and mortality and improving patient outcomes reflects an expectation that funded work will connect disease management approaches to tangible clinical and patient-centered results rather than remaining purely descriptive.

Administrative details place the announcement under NIH and associated research areas captured by CFDA numbers 93.361 (Nursing Research), 93.837 (Cardiovascular Diseases Research), and 93.866 (Aging Research, reflecting the strong overlap between heart failure burden and older populations). The opportunity was posted April 13, 2007, and later archived April 5, 2010, with the official details and historical FOA text available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-07-355.html. For technical issues accessing the full announcement or linking to it, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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