Opportunity Information: Apply for PAR 09 057

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Improving Interventions for Communication Disorders (R21/R33)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders.
  • This funding opportunity was created on Dec 19, 2008 and posted on Dec 19, 2008.
  • Applicants must submit their applications by Jun 28, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $400,000.00 to eligible and selected applicants.
  • Eligible applicants include: Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

Improving Interventions for Communication Disorders (R21/R33) is a National Institutes of Health funding opportunity from the National Institute on Deafness and Other Communication Disorders (NIDCD) focused on moving new ideas toward real-world tools and treatments for communication disorders. The program is meant to support innovative, milestone-driven projects that develop or refine diagnostic tools, intervention strategies, and treatments that could ultimately be used broadly and cost effectively. The scientific scope aligns with NIDCD mission areas, including hearing, balance, smell, taste, voice, speech, and language, and it explicitly welcomes translational and clinical research when it helps advance an intervention toward practical use.

The FOA uses a two-phase Exploratory/Developmental Phased Innovation mechanism (R21/R33). Applicants submit one integrated application that is clearly organized into an initial R21 phase followed by an R33 phase. The R21 portion is intended to support early development work where feasibility is tested, core methods are refined, or key proof-of-concept data are generated. If the project meets the predefined milestones, the work can transition into the R33 phase, which supports a more advanced stage of development such as expanded validation, optimization, or steps that move the intervention closer to adoption in clinical or applied settings. A central requirement is a separate statement explaining why the phased R21/R33 structure is necessary and laying out concrete, measurable milestones that will be used to judge progress and readiness to move from the R21 to the R33.

Funding and timing are structured to support development without exceeding set caps. The total project period can be up to five years. The R21 phase can last up to two years and is limited to $275,000 in direct costs total, with no more than $150,000 in direct costs in any single R21 year. The R33 phase can last up to four years and is limited to $1.5 million in direct costs total, with no more than $400,000 in direct costs in any single R33 year. The application must include separate, detailed, non-modular budgets for each phase, reflecting the staged nature of the work. Awards depend on available funds and the receipt of enough high-quality, competitive applications.

Applications must follow the PHS398 format, and the combined R21/R33 Research Plan (items 2 through 5) is limited to 25 pages total, with the milestones included inside that page limit. This constraint means applicants need to present a focused development plan, with milestones and decision points that are specific enough to guide the phased progression and allow reviewers to evaluate whether the project is realistically positioned to advance from exploratory work into a more substantial development and validation effort.

Eligibility is broad and includes many kinds of applicant organizations. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) nonprofits), small businesses, for-profit organizations (including those other than small businesses), Native American tribal governments and tribal organizations, and a range of other eligible entities described in the announcement. The FOA also notes additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and foreign (non-U.S.) entities. There is no cost-sharing or matching requirement.

On the investigator side, the FOA encourages any qualified individuals with the expertise and resources to apply through their institutions, and it specifically encourages participation by individuals from underrepresented racial and ethnic groups and individuals with disabilities. The application can name more than one Project Director/Principal Investigator under the NIH multiple PD/PI model. Applicants may submit multiple applications as long as each one is scientifically distinct. Resubmissions are allowed, but they must include an introduction that responds to the prior peer review critique (the Summary Statement), consistent with NIH resubmission policies referenced in the announcement.

Administrative details in the source information identify the opportunity as PAR-09-057 under CFDA 93.173 (Research Related to Deafness and Communication Disorders). It was posted December 19, 2008, with an original and final closing date of June 28, 2010, and an archive date of July 29, 2010. The estimated total funding listed in the source data is $400,000, and the FOA directs applicants to the NIH grants website for the full announcement and provides NIH Office of Extramural Research (OER) webmaster contact information for access or linking issues.

Frequently Asked Questions (FAQs): Improving Interventions for Communication Disorders (R21/R33)

What is the "Improving Interventions for Communication Disorders (R21/R33)" opportunity?

It is a National Institutes of Health (NIH) funding opportunity from the National Institute on Deafness and Other Communication Disorders (NIDCD) that supports innovative, milestone-driven projects intended to move new ideas toward real-world diagnostic tools, intervention strategies, and treatments for communication disorders.

Which NIH Institute is sponsoring this program?

The sponsoring Institute is the National Institute on Deafness and Other Communication Disorders (NIDCD).

What kinds of projects does this FOA aim to support?

The FOA is focused on developing or refining diagnostic tools, intervention strategies, and treatments that can ultimately be used broadly and cost effectively. It supports work that advances an intervention toward practical use, including translational and clinical research when it helps move the intervention closer to real-world adoption.

What scientific areas are within scope for this opportunity?

The scope aligns with NIDCD mission areas, including hearing, balance, smell, taste, voice, speech, and language.

Does this opportunity support translational or clinical research?

Yes. Translational and clinical research are explicitly welcomed when they help advance an intervention toward practical use.

What funding mechanism is used (R21/R33), and what does it mean?

The FOA uses the Exploratory/Developmental Phased Innovation mechanism (R21/R33). Applicants submit a single, integrated application that is organized into two sequential phases: an initial R21 phase followed by a subsequent R33 phase, with a transition based on achieving predefined milestones.

Do applicants submit two separate applications for the two phases?

No. Applicants submit one integrated application that clearly includes both the R21 phase and the R33 phase.

What is the purpose of the R21 phase in this program?

The R21 portion supports early development work where feasibility is tested, core methods are refined, or key proof-of-concept data are generated.

What is the purpose of the R33 phase in this program?

The R33 portion supports a more advanced stage of development such as expanded validation, optimization, or additional steps that move the intervention closer to adoption in clinical or applied settings.

How does a project move from the R21 phase to the R33 phase?

Transition to the R33 phase depends on whether the project meets predefined, concrete, measurable milestones established in the application. Those milestones are used to judge progress and readiness to move forward.

Are milestones required, and where do they go in the application?

Yes. The FOA requires concrete, measurable milestones, and they must be included within the combined R21/R33 Research Plan page limit.

Is there a required explanation for using a phased R21/R33 approach?

Yes. A central requirement is a separate statement explaining why the phased R21/R33 structure is necessary for the proposed work and how the milestones will be used to guide the transition from R21 to R33.

What is the maximum total project period?

The total project period can be up to five years.

How long can the R21 phase last?

The R21 phase can last up to two years.

How long can the R33 phase last?

The R33 phase can last up to four years.

What is the direct cost limit for the R21 phase?

The R21 phase is limited to $275,000 in direct costs total, with no more than $150,000 in direct costs in any single R21 year.

What is the direct cost limit for the R33 phase?

The R33 phase is limited to $1.5 million in direct costs total, with no more than $400,000 in direct costs in any single R33 year.

Does the FOA require separate budgets for the R21 and R33 phases?

Yes. The application must include separate, detailed, non-modular budgets for each phase, reflecting the staged nature of the project.

Is cost sharing or matching required?

No. There is no cost-sharing or matching requirement stated for this opportunity.

What application format is required?

Applications must follow the PHS398 format.

What is the page limit for the combined R21/R33 Research Plan?

The combined R21/R33 Research Plan (items 2 through 5) is limited to 25 pages total, and the milestones must be included within that 25-page limit.

Why is the page limit important for applicants?

Because the R21/R33 Research Plan and milestones must fit within 25 pages, applicants need a focused development plan with clear milestones and decision points that allow reviewers to assess whether the project can realistically progress from exploratory work to advanced development and validation.

Who is eligible to apply?

Eligibility is broad and includes many types of organizations, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) nonprofits), small businesses, for-profit organizations (including those other than small businesses), Native American tribal governments and tribal organizations, and other eligible entities described in the announcement.

Are minority-serving institutions and community organizations included as eligible applicants?

Yes. The FOA notes additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), and faith-based or community-based organizations.

Are federal agencies eligible to apply?

Yes. The FOA lists eligible federal agencies among additional eligible groups.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are included among additional eligible groups noted in the FOA.

Are foreign (non-U.S.) entities eligible to apply?

Yes. The FOA includes foreign (non-U.S.) entities among eligible applicants.

Who can serve as the Project Director/Principal Investigator (PD/PI)?

The FOA encourages any qualified individuals with the expertise and resources to apply through their institutions. It also encourages participation by individuals from underrepresented racial and ethnic groups and individuals with disabilities.

Can an application include multiple PDs/PIs?

Yes. The application can name more than one PD/PI under the NIH multiple PD/PI model.

Can an organization submit more than one application to this FOA?

Yes. Applicants may submit multiple applications as long as each application is scientifically distinct.

Are resubmissions allowed?

Yes. Resubmissions are allowed, but they must include an introduction that responds to the prior peer review critique (the Summary Statement), consistent with NIH resubmission policies referenced in the announcement.

Are awards guaranteed if an application is submitted?

No. Awards depend on available funds and the receipt of enough high-quality, competitive applications.

What is the FOA number and CFDA listing for this opportunity?

The opportunity is identified as PAR-09-057 under CFDA 93.173 (Research Related to Deafness and Communication Disorders).

When was this FOA posted, and what were the closing dates listed?

The FOA was posted December 19, 2008. The original and final closing date listed is June 28, 2010, and the archive date is July 29, 2010.

What estimated total funding is listed in the source information?

The estimated total funding listed in the source data is $400,000.

Where does the FOA direct applicants for the full announcement and help with access issues?

The FOA directs applicants to the NIH grants website for the full announcement and provides NIH Office of Extramural Research (OER) webmaster contact information for access or linking issues.

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