Improving Physical Infrastructure Revisions of Center Grants (P40) | Apply Online

Opportunity Summary:

The Improving Physical Infrastructure Revisions of Center Grants (P40) opportunity (RFA-OD-16-010) is a discretionary NIH grant funding announcement issued by HHS/NIH that supports revision applications to certain existing, active NIH Center Grant awards. Rather than funding brand-new center programs, this FOA is designed specifically for current NIH center grantees who need to update or expand the physical infrastructure that underpins animal model-based research conducted through, or in association with, the funded Center. In practical terms, the goal is to strengthen the research environment by investing in facility and equipment improvements that directly enhance the quality, capacity, reliability, and efficiency of animal model research.

The central focus is physical infrastructure improvements tied to animal model research needs. The FOA allows a range of possible revision activities depending on what investigators affiliated with the Center require to carry out their work. At one end of the spectrum, an applicant might request specialized equipment that enables more advanced animal model work or improves existing capabilities. At the other end, the FOA also supports alteration and renovation (A&R) projects, meaning construction-related updates such as modifying, renovating, or reconfiguring space to better support animal research operations. These improvements are meant to be responsive to the scientific and operational requirements of the Center's investigator community, so the proposed revisions should be clearly connected to concrete research needs and to the Center's overall mission and ongoing projects.

A notable expectation in this announcement is an emphasis on sustainability. Applicants are expected to propose sustainable designs and incorporate green technologies wherever feasible. This points to NIH interest not only in improving research functionality, but also in promoting modern, energy-efficient, environmentally responsible approaches to facility design and renovation. In the context of animal research infrastructure, that could reasonably include improvements that reduce energy and water use, enhance building system efficiency, or incorporate other environmentally preferable materials and technologies, while still meeting the strict performance, safety, and regulatory requirements typical for animal facilities and related research environments.

Eligibility is broad across major research and nonprofit institution types, but it is constrained by the program's structure: it is intended for revisions to active NIH Center Grants from participating NIH Institutes and Centers. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations both with and without 501(c)(3) status (with further clarification referenced in the full eligibility text). The funding activity category is Health, and the CFDA numbers associated with the opportunity are 93.351. The sponsor is NIH (HHS-NIH11).

Key timing details from the source data show the FOA was posted and created on April 22, 2016, with an application closing date of August 1, 2016 (both the original and current closing date are the same). The listing does not provide an award ceiling or expected number of awards in the provided fields, which typically means those details would need to be confirmed in the full FOA text or related NIH documentation.

Overall, this opportunity is best understood as a targeted mechanism for NIH-funded centers to modernize and improve the physical spaces and equipment that support animal model research, with an explicit push toward sustainable and green infrastructure solutions, and with project scope flexible enough to cover anything from critical equipment purchases to substantial renovation work when justified by the Center's research needs.

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