Improving Physical Infrastructure to Enhance Animal Model Research: Revisions of Specialized Center Cooperative Agreements (U54) | Apply Online

Opportunity Summary:

The grant opportunity titled "Improving Physical Infrastructure to Enhance Animal Model Research: Revisions of Specialized Center Cooperative Agreements (U54)" (RFA-OD-16-011) is a National Institutes of Health (NIH) funding announcement that supports upgrades to the physical infrastructure used for animal model research. Rather than funding brand-new centers or brand-new awards, it is aimed specifically at organizations that already hold an active NIH Specialized Center Cooperative Agreement (U54) from participating NIH Institutes and Centers. The mechanism is a cooperative agreement, which generally means the NIH expects to have substantial involvement in the project as it moves forward, compared with a traditional research grant.

The core purpose is to fund revision applications (often described as supplements or changes to an existing award) that improve facilities, capabilities, and/or specialized resources needed to strengthen animal model research being conducted by investigators affiliated with the supported Center. The announcement makes clear that the scope of proposed revisions should be driven by real, center-specific needs tied to animal model research. In practice, that means requests might be relatively targeted, such as acquiring specialized equipment that expands or modernizes animal research capacity, or they could be more facility-focused, including alteration and renovation (A and R) activities to modify existing space to better support animal model work. The intent is not simply general construction, but improvements that directly enhance the research environment and enable better, more effective, or more advanced animal model studies.

A notable emphasis of the opportunity is sustainability. Applicants are expected to incorporate sustainable design principles and to use green technologies where feasible. This signals that NIH is looking not only for functional upgrades but also for responsible infrastructure planning, such as energy-efficient systems, environmentally conscious materials, and designs that reduce long-term operating costs and environmental impact. The expectation of sustainability also implies that proposed improvements should be durable and maintainable over time, supporting ongoing research needs rather than serving as short-lived, one-off purchases or renovations.

Eligibility is limited to institutions that already have qualifying active U54 Specialized Center Cooperative Agreement awards, but the eligible organization types listed include a range of higher education institutions and nonprofit entities: public and state-controlled universities, private institutions of higher education, and nonprofit organizations with or without 501(c)(3) status (with additional eligibility details referenced in the full announcement). The opportunity is offered by the U.S. Department of Health and Human Services under NIH (agency listed as HHS-NIH11), and it falls under the health funding category. The CFDA numbers associated with the opportunity are 93.351 (as listed in the source data).

Key administrative details include a posting and creation date of May 24, 2016, and an application due date (original and current closing date) of August 1, 2016. The source data does not list an award ceiling or the expected number of awards, suggesting that those details were either not specified in the summary fields or were addressed elsewhere in the full FOA. Overall, the opportunity is best understood as a targeted NIH investment in modernizing and improving the built environment and specialized equipment base that animal model researchers rely on within existing NIH-funded U54 centers, with a strong preference for forward-looking, sustainable infrastructure choices.

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