Opportunity Information: Apply for PAR 16 201

  • The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.399,.
  • This funding opportunity was created on Apr 18, 2016 and posted on Apr 18, 2016.
  • Applicants must submit their applications by Jun 13, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PAR 16 201

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Opportunity Summary:

The grant opportunity titled "Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R21)" (Funding Opportunity Number PAR 16-201) is a National Institutes of Health (NIH) funding announcement under the U.S. Department of Health and Human Services (Agency listed as HHS-NIH11). It supports discretionary grant funding for research projects that aim to improve smoking cessation outcomes specifically among socioeconomically disadvantaged groups. The central idea is not just to test whether an intervention can work in a small, controlled setting, but to move the field toward approaches that are realistic to deliver at scale and capable of producing broad population-level impact.

This FOA is focused on intervention research that is both targeted and scalable. "Targeted" means the intervention should be designed with the needs, constraints, and lived realities of socioeconomically disadvantaged populations in mind, rather than treating these groups as an afterthought or simply analyzing them as a subgroup. "Scalable" means the approach should have credible potential for widespread delivery, such as through health systems, community settings, public programs, quitlines, digital platforms, housing authorities, or other channels that can reach large numbers of people without requiring unusually intensive resources or specialized staffing. The announcement encourages innovation, but it also makes room for practical improvements to interventions that are already being used at scale.

Applicants can propose two broad types of projects. First, they may develop and test novel smoking cessation interventions that are promising and designed from the start to be scalable. These might include new combinations of behavioral support and pharmacotherapy strategies, technology-enabled interventions (for example, text-based coaching, app-based supports, telehealth, or other low-burden tools), or approaches that better address common barriers faced by lower-income populations such as unstable housing, limited transportation, competing work and caregiving demands, lower access to healthcare, or higher stress exposure. Second, applicants may focus on enhancing interventions that are already widely available or already implemented in real-world settings, with an emphasis on improving effectiveness, quality, accessibility, utilization, and cost-effectiveness. In practice, that could mean improving engagement and retention, reducing drop-off, increasing reach among people who are least likely to use cessation services, making services easier to access, strengthening implementation quality, or identifying ways to deliver comparable results at lower cost.

The funding mechanism is an NIH R21, which is typically used for early-stage, exploratory, or high-potential projects that may not yet have extensive preliminary data but have a strong rationale and a clear plan. Consistent with that intent, the FOA provides support for up to two years and is explicitly aimed at protocol development and early-phase work, including pilot or exploratory studies. The listed award ceiling is $200,000, reinforcing that this is meant to seed promising intervention concepts and generate the early evidence needed to justify larger trials or broader implementation studies later.

Eligibility is broad and includes many types of organizations that could credibly conduct and test cessation interventions in disadvantaged communities. Eligible applicants include state, county, city, and special district governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses, along with other entities as described in the full eligibility language. This wide eligibility reflects the FOA's emphasis on interventions that can be delivered through diverse real-world systems that interact with disadvantaged populations.

Key administrative details in the source information include the CFDA numbers 93.399 (and another listing in the same field), the original and current closing date of June 13, 2019, and a creation and posting date of April 18, 2016. While the dates indicate this specific opportunity had a 2019 deadline, the summary above captures the substance of what the FOA sought to fund: practical, innovative research designed to measurably improve quit outcomes for socioeconomically disadvantaged smokers in ways that can realistically be expanded to reach many people.

Frequently Asked Questions (FAQs)

What is the title of this grant opportunity?

The opportunity is titled "Improving Smoking Cessation in Socioeconomically Disadvantaged Populations via Scalable Interventions (R21)."

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is PAR 16-201.

Which agency is offering this grant?

This is a National Institutes of Health (NIH) funding announcement under the U.S. Department of Health and Human Services (HHS). The agency is listed as HHS-NIH11.

What is the purpose of this funding opportunity?

The purpose is to support research projects that improve smoking cessation outcomes among socioeconomically disadvantaged populations, with a strong emphasis on interventions that can be delivered realistically at scale and that have the potential to produce broad population-level impact.

Who is the intended focus population for the research?

The focus is specifically on socioeconomically disadvantaged groups. The FOA emphasizes designing interventions around the needs and constraints of these populations (not treating them as an afterthought or only analyzing them as a subgroup).

What does "targeted" mean in the context of this FOA?

"Targeted" means the intervention should be designed with the lived realities and constraints of socioeconomically disadvantaged populations in mind. The goal is to build the approach around the population from the start, rather than simply testing a general intervention and then checking outcomes for disadvantaged participants afterward.

What does "scalable" mean in the context of this FOA?

"Scalable" means the intervention should have a credible path to being delivered widely to large numbers of people without requiring unusually intensive resources or specialized staffing. The FOA points to delivery channels such as health systems, community settings, public programs, quitlines, digital platforms, housing authorities, and other real-world systems that can reach disadvantaged populations.

What types of projects does the FOA support?

Applicants may propose two broad types of projects: (1) developing and testing novel smoking cessation interventions designed from the start to be scalable, or (2) enhancing interventions that are already widely available or already implemented in real-world settings to improve outcomes and delivery.

What are examples of "novel" interventions that could fit this FOA?

Examples described in the FOA summary include new combinations of behavioral support and pharmacotherapy strategies, and technology-enabled interventions such as text-based coaching, app-based supports, telehealth, or other low-burden tools designed to be deliverable at scale.

What kinds of barriers faced by disadvantaged populations does the FOA expect interventions to address?

The FOA highlights barriers such as unstable housing, limited transportation, competing work and caregiving demands, lower access to healthcare, and higher stress exposure. Projects can be designed to reduce the impact of these barriers on quitting and on sustained engagement with cessation support.

What does it mean to "enhance" an intervention that is already used at scale?

It means building on cessation services that already exist in real-world settings and improving their effectiveness, quality, accessibility, utilization, and cost-effectiveness. The FOA is open to practical improvements, not only brand-new concepts.

What are examples of enhancements to existing cessation interventions mentioned or implied in the FOA summary?

The summary emphasizes improvements such as increasing engagement and retention, reducing drop-off, increasing reach among people least likely to use cessation services, making services easier to access, strengthening implementation quality, and finding ways to deliver comparable results at lower cost.

What grant mechanism is used for this opportunity?

This opportunity uses the NIH R21 mechanism.

What is an NIH R21 intended to support?

An R21 is typically used for early-stage, exploratory, or high-potential research. It is often appropriate for projects that may not yet have extensive preliminary data but have a strong rationale and a clear plan to generate early evidence.

How long is the project period supported by this FOA?

The FOA provides support for up to two years.

What is the maximum award amount (award ceiling) listed in the provided information?

The listed award ceiling is $200,000.

Is this FOA more focused on large trials or early-phase work?

Based on the R21 mechanism and the described intent, it is aimed at protocol development and early-phase work, including pilot or exploratory studies, to seed promising concepts that could justify larger trials or broader implementation studies later.

Does the FOA require that interventions be delivered in real-world systems?

The FOA strongly emphasizes interventions that are realistic to deliver at scale through real-world channels (for example, health systems, community settings, public programs, quitlines, digital platforms, and housing authorities). The intent is to move beyond small, controlled settings toward approaches capable of broad impact.

What kinds of organizations are eligible to apply?

Eligibility is broad and includes state, county, city, and special district governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other entities as described in the full eligibility language.

Why does the FOA include such a wide range of eligible applicants?

The FOA is designed to support interventions that can be delivered through diverse systems that interact with socioeconomically disadvantaged populations in real-world contexts, so eligibility includes many types of organizations positioned to implement or test scalable cessation approaches.

What are the CFDA numbers associated with this opportunity?

The provided information lists CFDA number 93.399 (and indicates another listing in the same field).

What were the key dates for this FOA?

The creation and posting date is April 18, 2016. The original and current closing date listed is June 13, 2019.

Is this specific opportunity still open based on the dates provided?

Based on the closing date provided (June 13, 2019), this specific opportunity appears to have had a deadline in 2019.

What is the overarching theme of the FOA as described in the summary?

The theme is improving quit outcomes for socioeconomically disadvantaged smokers using practical, innovative research approaches that can realistically be expanded to reach many people and achieve population-level impact.

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