Opportunity Information: Apply for PAR 16 253
Apply for PAR 16 253
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Informatics Methodology and Secondary Analyses to Explore Shared Immunology Study Data in ImmPort (UH2)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855, 93.856,.
- This funding opportunity was created on May 10, 2016 and posted on May 10, 2016.
- Applicants must submit their applications by Oct 04, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The funding opportunity titled "Informatics Methodology and Secondary Analyses to Explore Shared Immunology Study Data in ImmPort (UH2)" (Funding Opportunity Number PAR 16-253) is a discretionary U.S. government grant program offered by the National Institutes of Health within the U.S. Department of Health and Human Services (Agency: HHS-NIH). It uses the cooperative agreement mechanism (UH2), which typically means funded projects are expected to involve active scientific or programmatic involvement from NIH staff compared with a standard grant. The overall focus is on health-related research, specifically immunology data reuse and analysis, leveraging the ImmPort repository, a shared resource that houses immunology study data intended to support broader discovery and reproducible research.
The FOA has two tightly connected goals. First, it seeks to fund the creation or improvement of informatics tools, computational methods, and related approaches that make it easier to reuse, integrate, and analyze data already deposited in ImmPort. This can include developing better ways to search, harmonize, standardize, curate, visualize, and compute across datasets, as well as methods that address practical barriers to secondary use such as inconsistent metadata, heterogeneous assay formats, varying clinical annotations, and differing study designs. In effect, the opportunity is aimed at strengthening the technical and methodological infrastructure that turns shared immunology datasets into something more findable, interoperable, and analytically useful for the broader community.
Second, the FOA supports secondary analyses of existing immunology datasets available through ImmPort to answer important basic and clinical immunology questions. Rather than funding new data collection, this part of the opportunity is about extracting new scientific insights from data that already exist, such as identifying immune signatures associated with disease, treatment response, vaccination outcomes, or underlying mechanisms of immune dysfunction. Secondary analyses may involve combining multiple studies, applying new statistical or machine learning methods, reanalyzing data with improved pipelines, or testing new hypotheses that were not addressed in the original studies. The intent is to accelerate discovery by maximizing the value of shared datasets, encouraging reproducibility, and reducing the need to generate redundant data when high-quality data are already available.
The program is associated with CFDA numbers 93.855 and 93.856, placing it within NIH health research assistance programs. The award ceiling listed is $200,000, indicating an upper bound on the amount that can be requested per award under this announcement. While the expected number of awards is not specified in the provided listing, the structure and scope suggest competitive selection based on the proposed tool development or analysis plan, the significance of the immunology questions, the strength of the computational and immunology expertise on the team, and the likely impact on the broader ImmPort user community.
Eligibility is broad and includes many types of organizations: state, county, city, and township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized as governments; public housing authorities and Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses. The listing also references an "Others" category with additional eligibility details in the full FOA text, signaling that additional applicant types may qualify under certain conditions.
Key dates show that the FOA was created and posted on May 10, 2016, with an original and current closing date of October 4, 2018. That means the specific competition described in the listing is historically dated and no longer open as of the closing date provided. Even so, the summary reflects a common NIH priority area: improving reuse of high-value shared biomedical datasets through better informatics, while simultaneously incentivizing rigorous secondary analyses that produce publishable biological and clinical insights.
In practical terms, this opportunity was designed for teams that can either (1) build or enhance computational capabilities that help researchers work with ImmPort immunology data at scale, or (2) deliver strong, methodologically sound reanalyses of ImmPort datasets that answer meaningful immunology questions. The overall public value proposition is that shared repositories only reach their potential when the community has robust tools and methods to navigate them and when researchers are supported in doing careful, creative reanalysis that translates existing data into new knowledge.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The funding opportunity is titled "Informatics Methodology and Secondary Analyses to Explore Shared Immunology Study Data in ImmPort (UH2)" and the Funding Opportunity Number is PAR 16-253.
Which agency offers this funding opportunity?
This is a discretionary U.S. government grant program offered by the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services (HHS). The listing identifies the agency as HHS-NIH.
What type of award mechanism is used?
The opportunity uses a cooperative agreement mechanism (UH2). A cooperative agreement generally means NIH staff are expected to have active scientific or programmatic involvement in the funded project compared with a standard grant.
What is the overall focus of the program?
The focus is health-related research centered on immunology data reuse and analysis, specifically leveraging the ImmPort repository (a shared resource that houses immunology study data). The intent is to support broader discovery and reproducible research by making shared immunology datasets more usable and by encouraging rigorous secondary analyses.
What is ImmPort in the context of this opportunity?
ImmPort is described as a shared repository that houses immunology study data. In this FOA, ImmPort is the primary data resource to be used for tool development, computational methodology, and secondary analyses of existing datasets.
What are the two main goals of this FOA?
The FOA has two tightly connected goals:
- Support the creation or improvement of informatics tools and computational methods that make it easier to reuse, integrate, and analyze data already deposited in ImmPort.
- Support secondary analyses of existing immunology datasets available through ImmPort to answer important basic and clinical immunology questions.
What kinds of projects fit under the informatics tools and methods goal?
Projects may focus on developing or improving tools and methods that help researchers work with ImmPort data more effectively. Examples mentioned include approaches to search, harmonize, standardize, curate, visualize, and compute across datasets. The FOA also emphasizes methods that reduce practical barriers to secondary use, such as inconsistent metadata, heterogeneous assay formats, varying clinical annotations, and differing study designs.
What kinds of projects fit under the secondary analysis goal?
Secondary analysis projects are expected to use existing immunology datasets in ImmPort (rather than collecting new data) to generate new scientific insights. Examples described include identifying immune signatures related to disease, treatment response, vaccination outcomes, or mechanisms of immune dysfunction. The FOA also contemplates combining multiple studies, applying new statistical or machine learning methods, reanalyzing data with improved pipelines, and testing new hypotheses not addressed in the original studies.
Does this program fund new data collection?
Based on the description provided, the secondary analysis component is explicitly focused on extracting new insights from data that already exist in ImmPort rather than funding new data collection.
What types of data challenges is the FOA trying to address?
The FOA highlights common barriers to reusing shared immunology datasets, including inconsistent metadata, heterogeneous assay formats, varying clinical annotations, and differing study designs. Tool and method development is intended to help overcome these issues so the datasets become more findable, interoperable, and analytically useful.
What is meant by making data more "findable" and "interoperable" in this context?
In this FOA, the concept is tied to improving practical reuse of ImmPort datasets through better search capabilities, harmonization/standardization, curation, and integration methods. The aim is to make it easier for researchers to locate relevant datasets, combine them appropriately, and analyze them in a reproducible way.
How does this opportunity support reproducible research?
The summary describes the program as encouraging reproducibility by improving the technical and methodological infrastructure for working with shared datasets and by supporting careful, rigorous secondary analyses that maximize the value of data already deposited in ImmPort.
What are the CFDA numbers associated with this program?
The program is associated with CFDA numbers 93.855 and 93.856.
What is the award ceiling?
The award ceiling listed is $200,000, indicating an upper bound on the amount that can be requested per award under this announcement.
How many awards were expected to be made?
The provided listing does not specify the expected number of awards.
What factors are likely to matter in competitive selection?
While the full review criteria are not provided in the listing, the description suggests competitive selection based on the proposed tool development or analysis plan, the significance of the immunology questions, the strength of the computational and immunology expertise on the team, and the likely impact on the broader ImmPort user community.
Who is eligible to apply?
Eligibility is described as broad. The listing includes:
- State, county, city, and township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Native American tribal organizations not federally recognized as governments
- Public housing authorities and Indian housing authorities
- Nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories)
- For-profit organizations other than small businesses
- Small businesses
What does the "Others" eligibility category mean?
The listing references an "Others" category with additional eligibility details in the full FOA text, which indicates that additional applicant types may qualify under certain conditions as defined in the full announcement.
What were the key dates for this funding opportunity?
The FOA was created and posted on May 10, 2016. The original and current closing date listed is October 4, 2018.
Is this funding opportunity still open?
No. Based on the closing date provided (October 4, 2018), the specific competition described in the listing is historically dated and is no longer open.
What kinds of teams was this opportunity designed for?
The description indicates it was designed for teams that can either (1) build or enhance computational capabilities that help researchers work with ImmPort immunology data at scale, or (2) deliver strong, methodologically sound secondary analyses of ImmPort datasets that answer meaningful immunology questions.
Why does the FOA emphasize secondary analyses of shared datasets?
The summary frames the public value proposition as maximizing the value of high-quality shared datasets, accelerating discovery, encouraging reproducibility, and reducing the need to generate redundant data when relevant data already exist in ImmPort.
What is the main intended impact on the research community?
The intended impact is to strengthen the technical and methodological infrastructure around ImmPort data and to produce new biological and clinical insights through secondary analyses, benefiting the broader ImmPort user community.
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