Opportunity Information: Apply for RFA HG 10 019
Apply for RFA HG 10 019
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Informatics Tools for High Throughput Sequence Data Analysis (SBIR) (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Dec 13, 2010 and posted on Dec 13, 2010.
- Applicants must submit their applications by Mar 3, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The Informatics Tools for High Throughput Sequence Data Analysis (SBIR) (R43/R44) funding opportunity (RFA-HG-10-019) was a National Institutes of Health grant solicitation, issued through the National Human Genome Research Institute program area, aimed specifically at small businesses developing software for modern DNA sequencing workflows. The central purpose was not to fund brand-new exploratory concepts from scratch, but to support the next stage of development for existing computational tools so they could mature into products that typical biological and biomedical research laboratories could adopt without extensive in-house engineering. In practical terms, the NIH was looking for projects that take software that already works in some form and make it robust, reliable, well documented, and well supported so that it can be deployed broadly and used confidently by many investigators.
The scope of responsive projects covered a wide range of sequence-data tasks that are common pain points for researchers and clinicians handling large-scale data from contemporary sequencing instruments. The announcement explicitly called out applications such as sequence quality assessment, read alignment, genome or transcriptome assembly, variant calling, and variant interpretation, while also leaving room for other analysis or processing functions where there was clear existing demand or strong likelihood of near-term demand. The emphasis on demand is important: the program was geared toward tools that solve broadly shared problems across many labs, not niche pipelines usable only in a very specific setting. Another key aspect was flexibility in software packaging, since the FOA welcomed both stand-alone tools and integrated suites of programs, as long as they addressed sequence data processing or analysis needs in a way that would scale to high-throughput realities.
This opportunity fell under the Small Business Innovation Research (SBIR) mechanisms R43/R44, meaning it was designed for U.S. small businesses to develop and potentially commercialize biomedical research technologies, in this case informatics products for sequencing data. The funding instrument type was a grant, and the activity category was Health (CFDA 93.172, Human Genome Research). There was no cost sharing or matching requirement, which lowered barriers for small companies that might not have significant non-federal capital available for development work.
In terms of timing and funding levels, the FOA was posted on December 13, 2010, with an original and current closing date of March 3, 2011, and an archive date of April 3, 2011, indicating it is no longer active. The estimated total funding available across awards was listed as $2,000,000, and the award ceiling was $150,000. Eligible applicants were limited to small businesses, consistent with the SBIR focus, and the sponsoring agency was the National Institutes of Health.
Overall, the solicitation reflects a common translational gap in bioinformatics: many sequencing tools begin as academically developed code that works for the original lab but lacks the engineering polish needed for widespread adoption. NIH used this SBIR call to encourage small businesses to professionalize those tools by improving reliability, performance, usability, documentation, and support, ultimately helping the broader research and clinical communities analyze high-throughput sequencing data more effectively. For full details, the original announcement was hosted by NIH at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-10-019.html.
Frequently Asked Questions (FAQs)
What is the "Informatics Tools for High Throughput Sequence Data Analysis (SBIR) (R43/R44)" opportunity?
It was a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) grant solicitation focused on software tools for modern high-throughput DNA sequencing workflows. The opportunity is identified as RFA-HG-10-019 and was issued through the National Human Genome Research Institute (NHGRI) program area.
Which agency sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH), with the program area associated with the National Human Genome Research Institute (NHGRI).
Is this opportunity still open?
No. The opportunity is archived and is no longer active. It was posted on December 13, 2010, had a closing date of March 3, 2011 (original and current), and an archive date of April 3, 2011.
What was the main purpose of this SBIR solicitation?
The main purpose was to support the next stage of development for existing sequencing-data analysis software so it could mature into products that typical biological and biomedical research laboratories could adopt without extensive in-house engineering. The emphasis was on making tools robust, reliable, well documented, and well supported for broad deployment.
Was this funding meant for brand-new exploratory concepts?
No. The solicitation emphasized advancing software that already works in some form, rather than funding brand-new exploratory concepts from scratch.
Who was eligible to apply?
Eligible applicants were limited to small businesses, consistent with the SBIR R43/R44 mechanisms.
What SBIR mechanisms were used for this opportunity?
The opportunity used SBIR mechanisms R43 and R44.
What type of funding instrument was offered?
The funding instrument type was a grant.
What program area or CFDA listing was associated with this opportunity?
The activity category was Health, listed under CFDA 93.172 (Human Genome Research).
What kinds of projects were considered responsive?
Responsive projects were those addressing high-throughput sequencing data processing or analysis needs with clear existing demand or strong likelihood of near-term demand, especially problems broadly shared across many labs.
What example sequencing-data tasks were explicitly called out?
The announcement explicitly called out tasks such as sequence quality assessment, read alignment, genome or transcriptome assembly, variant calling, and variant interpretation.
Did the scope allow other sequence-data analysis or processing functions beyond the examples listed?
Yes. The scope left room for other analysis or processing functions where there was clear existing demand or a strong likelihood of near-term demand.
Did the solicitation favor tools for broad use or niche pipelines?
It emphasized tools that solve broadly shared problems across many laboratories rather than niche pipelines usable only in a very specific setting.
Were applicants expected to focus on software packaging, such as stand-alone tools versus suites?
The solicitation welcomed both stand-alone tools and integrated suites of programs, as long as they addressed sequence data processing or analysis needs and could scale to high-throughput realities.
What kinds of improvements were the NIH looking for in supported projects?
The focus was on professionalizing existing tools by improving reliability, performance, usability, documentation, and support so many investigators could use them confidently.
Was commercialization part of the intent of this opportunity?
Yes. As an SBIR opportunity for small businesses, it was designed to support development and potential commercialization of biomedical research technologies, in this case informatics products for sequencing data.
Was there a cost sharing or matching requirement?
No. There was no cost sharing or matching requirement.
How much total funding was estimated to be available?
The estimated total funding available across awards was listed as $2,000,000.
What was the award ceiling?
The award ceiling was $150,000.
Where could applicants find the original full announcement?
The original announcement was hosted by NIH at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-10-019.html.
Why did NIH issue a solicitation like this for sequencing informatics tools?
The solicitation targeted a common translational gap in bioinformatics: tools often start as academically developed code that works for the original lab but lacks the engineering polish needed for widespread adoption. This SBIR call aimed to help small businesses bring those tools to a more deployable, broadly usable product level.
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