Inner City Asthma Consortium (UM1) | Apply Online

Opportunity Summary:

The Inner City Asthma Consortium (ICAC) (UM1) funding opportunity, issued by the National Institutes of Health under Funding Opportunity Number RFA-AI-13-036, was a cooperative agreement designed to support a single awardee that would both lead and carry out a coordinated clinical research program focused on asthma in inner-city populations. The core purpose was not simply to run isolated studies, but to take on the scientific leadership, operational coordination, and administrative responsibilities needed to keep the ICAC functioning as a multi-site, collaborative research enterprise. The overall emphasis was on improving prevention and treatment strategies for asthma where disease burden is often highest and where social and environmental conditions can complicate management, with an expectation that the awardee would guide an agenda that is directly relevant to the realities of inner-city communities.

Scientifically, the opportunity centered on conducting clinical trials and mechanistic studies that would deepen understanding of asthma immunopathogenesis while also testing and developing interventions tailored to inner-city populations. In practical terms, that means the consortium was expected to do two things in parallel: (1) run rigorous clinical studies that evaluate interventions that could reduce symptoms, exacerbations, and health disparities, and (2) pursue mechanistic research that explains why particular interventions work (or do not work) in these populations, including immune and biological pathways that shape disease expression and treatment response. By combining clinical trials with mechanistic investigation, the program aimed to generate evidence that is both actionable for patient care and informative for future therapeutic development, rather than producing results that are difficult to translate into real-world improvements.

From a funding and administrative standpoint, this was a discretionary NIH opportunity using the Cooperative Agreement mechanism, which typically signals substantial NIH program involvement compared with standard grants. The expected number of awards was one, with an estimated total funding level of about $10,000,000, indicating NIH intended to invest in a single leadership site (and its network structure) capable of managing a large, complex research program. The activity aligned with health research priorities and was associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), reflecting the immunologic and infectious-disease-relevant dimensions that can intersect with asthma research.

Eligibility was broad across U.S.-based organizations and governmental entities, including public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, excluding certain cases), for-profit organizations (including small businesses), and a range of government bodies (state, county, city/township, special district, and independent school districts), as well as public housing authorities/Indian housing authorities. The FOA also explicitly listed additional eligible applicants such as Historically Black Colleges and Universities, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, along with faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. At the same time, it clearly excluded non-U.S. (foreign) institutions and non-U.S. components of U.S. organizations, and it did not allow foreign components as defined by NIH policy. No cost sharing or matching requirement was indicated, lowering a common barrier to entry for many applicants.

Timing-wise, the announcement was posted on August 26, 2013, with an original and current closing date of December 20, 2013, and an archive date of January 20, 2014, meaning it is no longer active but remains a useful reference point for understanding NIH priorities and the structure of large cooperative, consortium-style asthma research programs. The full announcement was hosted on the NIH grants site, and NIH’s Office of Extramural Research provided contact points for technical access issues. Overall, the opportunity was built to sustain and advance a national, inner-city-focused asthma research consortium through a single, highly capable leadership awardee responsible for both high-quality science and the complex coordination needed to run multi-center clinical and mechanistic studies at scale.

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