Opportunity Information: Apply for RFA AI 14 006
Apply for RFA AI 14 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Innovation for HIV Vaccine Discovery (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Feb 18, 2014 and posted on Feb 18, 2014.
- Applicants must submit their applications by Jul 15, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Small businesses Private institutions of higher education Native American tribal governments (Federally recognized) County governments For profit organizations other than small businesses City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts State governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
Innovation for HIV Vaccine Discovery (R01) is a National Institutes of Health (NIH) grant opportunity (Funding Opportunity Number RFA-AI-14-006) designed to push the field of HIV vaccine research toward bold, unconventional early-stage ideas. The central goal is to fund innovative, high-risk, high-impact discovery research that can uncover new vaccine concepts, new immune targets, or fundamentally new approaches that could ultimately enable the design of an effective HIV immunogen. In practical terms, the announcement is looking for projects that do not simply refine existing approaches, but instead introduce fresh scientific strategies that could materially change how researchers think about HIV vaccine design and immunization.
A major emphasis of the FOA is on the earliest phases of vaccine discovery rather than late-stage development or large clinical efforts. NIH highlights a desire for new ideas that lead to newly engineered versions of conventional vaccine approaches or entirely novel vaccine platforms and strategies. The expected payoff is not necessarily a finished vaccine, but discoveries that have clear potential to influence immunogen design or immunization strategies in ways that could produce long-term protection either against acquiring HIV infection or against ongoing infection. The FOA explicitly frames the objective around durable protection, which signals interest in immune responses that can last and remain effective over time, a key hurdle in HIV vaccinology.
The opportunity is intentionally broad in who can apply and is structured to welcome both established and new investigators. Importantly, it does not require prior expertise in HIV prevention research as a prerequisite, which is a notable feature meant to attract creative ideas and technical approaches from outside the traditional HIV vaccine community. This opens the door to investigators in adjacent fields such as protein engineering, structural biology, computational biology, immunology, systems vaccinology, synthetic biology, vector design, nanoparticle delivery, and other cutting-edge disciplines that could contribute new solutions to long-standing HIV vaccine challenges.
From an administrative standpoint, this is a discretionary grant using the NIH R01 mechanism and falls under the health activity category. The related CFDA numbers listed are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). The FOA states there is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of the award. The estimated total funding amount for the opportunity is $2,000,000, reflecting a competitive pool intended to support a set of meritorious projects aligned with the FOA’s innovation-driven goals.
Eligibility is expansive and includes many types of applicant organizations. Eligible applicants include small businesses, for-profit organizations, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), private and public institutions of higher education, and a wide range of government entities such as state governments, county governments, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities. The FOA also explicitly includes tribal governments and tribal organizations, including Federally recognized tribal governments as well as other tribal entities. In addition, the eligibility language highlights many institution types commonly emphasized in federal research funding, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian-serving Institutions, Asian American and Native American Pacific Islander-serving Institutions (AANAPISIs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, and eligible federal agencies.
The announcement also allows substantial international participation. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, and non-U.S. components of U.S. organizations may also apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed, which indicates NIH is open to international collaborations and research activities when scientifically justified and aligned with program goals.
Key dates provided in the source information show the FOA was posted and created on February 18, 2014, with an original and current closing date of July 15, 2014, and an archive date of August 15, 2014. While these dates indicate the specific announcement cycle has closed and been archived, the summary still captures the intent and structure of the opportunity, and similar innovation-focused HIV vaccine discovery initiatives may reappear in future NIH solicitations.
For applicants seeking the full text, NIH provided an additional information link to the official RFA page hosted on the NIH grants site. For access issues or technical problems with the announcement link, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the "Innovation for HIV Vaccine Discovery (R01)" funding opportunity?
Innovation for HIV Vaccine Discovery (R01) is a National Institutes of Health (NIH) grant opportunity that uses the NIH R01 mechanism to support early-stage HIV vaccine discovery research. It is identified by Funding Opportunity Number RFA-AI-14-006 and is designed to encourage bold, unconventional ideas in HIV vaccine research.
What is the main goal of this FOA?
The central goal is to fund innovative, high-risk, high-impact discovery research that can uncover new vaccine concepts, new immune targets, or fundamentally new approaches that could ultimately enable the design of an effective HIV immunogen.
What type of research does NIH want to support under this announcement?
The FOA emphasizes the earliest phases of vaccine discovery. It seeks projects that introduce fresh scientific strategies rather than incremental refinements of existing approaches, with the intention of shifting how researchers think about HIV vaccine design and immunization.
Does the FOA focus on late-stage development or clinical trials?
No. A major emphasis is on early discovery research rather than late-stage development or large clinical efforts.
What kinds of outcomes are expected from funded projects?
The expected payoff is not necessarily a finished vaccine. Instead, NIH is looking for discoveries with clear potential to influence immunogen design or immunization strategies, including advances that could support long-term, durable protection against acquiring HIV infection or against ongoing infection.
What does "durable protection" mean in the context of this FOA?
The FOA frames its objective around durable protection, signaling interest in immune responses that can last and remain effective over time, which is described as a key hurdle in HIV vaccinology.
Are unconventional or entirely new vaccine platforms encouraged?
Yes. NIH highlights a desire for new ideas that lead to newly engineered versions of conventional vaccine approaches or entirely novel vaccine platforms and strategies.
Who is this opportunity meant for?
The opportunity is intentionally broad and is structured to welcome both established and new investigators.
Is prior experience in HIV prevention research required to apply?
No. The FOA does not require prior expertise in HIV prevention research as a prerequisite, with the intent of attracting creative ideas and technical approaches from outside the traditional HIV vaccine community.
What kinds of fields or disciplines might be a good fit for this FOA?
The FOA explicitly notes that investigators in adjacent or enabling fields may contribute new solutions, including areas such as protein engineering, structural biology, computational biology, immunology, systems vaccinology, synthetic biology, vector design, nanoparticle delivery, and other cutting-edge disciplines.
What funding mechanism is used?
This is a discretionary grant opportunity using the NIH R01 mechanism.
What is the health activity category for this opportunity?
The opportunity falls under the health activity category.
What CFDA numbers are associated with this FOA?
The related CFDA numbers listed are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.
What is the estimated total funding available?
The estimated total funding amount for the opportunity is $2,000,000, representing a competitive pool intended to support meritorious projects aligned with the FOA's innovation-driven goals.
What types of organizations are eligible to apply?
Eligibility is expansive. Eligible applicants include small businesses, for-profit organizations, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), private and public institutions of higher education, and many government entities.
Which government entities are listed as eligible applicants?
The FOA includes state governments, county governments, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes tribal governments and tribal organizations, including Federally recognized tribal governments and other tribal entities.
Are certain institution types specifically highlighted as eligible?
Yes. The eligibility language highlights institution types commonly emphasized in federal research funding, including HBCUs, Hispanic-serving Institutions, Alaska Native and Native Hawaiian-serving Institutions, AANAPISIs, TCCUs, faith-based or community-based organizations, and eligible federal agencies.
Can non-U.S. organizations apply?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, and non-U.S. components of U.S. organizations may also apply.
Are foreign components allowed in projects?
Yes. Foreign components (as defined in the NIH Grants Policy Statement) are allowed, indicating NIH is open to international collaborations and research activities when scientifically justified and aligned with program goals.
When was this FOA posted and when did it close?
The FOA was posted and created on February 18, 2014. The original and current closing date listed is July 15, 2014.
Is this funding opportunity still open?
No. The key dates indicate the specific announcement cycle closed on July 15, 2014 and the FOA was archived on August 15, 2014.
Where can applicants find the official FOA details?
NIH provided an additional information link to the official RFA page hosted on the NIH grants site.
Who should be contacted for technical problems accessing the FOA link?
For access issues or technical problems with the announcement link, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is RFA-AI-14-006.
Browse more opportunities from the same category: Health
Next opportunity: NPS Interpretation, Education and Volunteers Business Plan 2014
Previous opportunity: BJA FY 14 John R. Justice Program
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA AI 14 006
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA AI 14 006) also looked into and applied for these:
| Funding Opportunity |
|---|
| APHL CDC Partnership for Quality Lab Practice Apply for CDC RFA HM10 100105CONT14 Funding Number: CDC RFA HM10 100105CONT14 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Development and Translation of Medical Technologies to Reduce Health Disparities (SBIR) (R43/R44) Apply for RFA EB 14 001 Funding Number: RFA EB 14 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Grants for the Benefit of Homeless Individuals Services in Supportive Housing (Short Title GBHI SSH) Apply for TI 14 007 Funding Number: TI 14 007 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $400,000 |
| Service Area Competition Additional Areas (AL, AZ, CA, CO, KY, MO, MS, MT, NC, NJ, NY, OK, OR, PA, PR, TN, and TX) Apply for HRSA 14 128 Funding Number: HRSA 14 128 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| FY14 Announcement of Availability of Funds for Family Planning Research and Data Analysis Cooperative Agreements Apply for PA FPR 14 001 Funding Number: PA FPR 14 001 Agency: Office of the Assistant Secretary for Health Category: Health Funding Amount: $400,000 |
| Collaboration on Climate Sensitive Diseases and Health Effects Apply for RFA CK 14 003 Funding Number: RFA CK 14 003 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $400,000 |
| Cooperative Agreement for a Providers Clinical Support System for the Appropriate Use of Opioids in the Treatment of Pain and Opioid related Addiction (Short Title PCSS Opioids) Apply for TI 14 009 Funding Number: TI 14 009 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $1,000,000 |
| Prevention Innovation Program (PIP) (R01) Apply for RFA AI 13 059 Funding Number: RFA AI 13 059 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| National Center of Excellence for the Prevention of Childhood Agricultural Injury Apply for RFA OH 14 005 Funding Number: RFA OH 14 005 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,200,000 |
| Supporting Improved Health for all People in the Kingdom of Cambodia by Strengthening the Ministry of Healths Capacity to Lead Disease Prevention and Control Efforts and Develop Sustainable Health Delivery Systems under the Presidents Emergency Plan Apply for CDC RFA GH12 122603CONT14 Funding Number: CDC RFA GH12 122603CONT14 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| First in Human and Early Stage Clinical Trials of Novel Investigational Drugs for Psychiatric Disorders (U01) Apply for PAR 14 107 Funding Number: PAR 14 107 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Exploratory Clinical Trials of Novel Interventions for Mental Disorders (R21/R33) Apply for RFA MH 15 300 Funding Number: RFA MH 15 300 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Exploratory Clinical Trials of Novel Interventions for Mental Disorders (R33) Apply for RFA MH 15 310 Funding Number: RFA MH 15 310 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pilot Effectiveness Studies and Services Research Grants (R34) Apply for RFA MH 15 330 Funding Number: RFA MH 15 330 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Affordable Care Act State Loan Repayment Program (SLRP) Apply for HRSA 14 033 Funding Number: HRSA 14 033 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Improving the Impact of Laboratory Practice A New Paradigm for Metrics, CSELS and DLPSS Apply for CDC RFA OE13 130402CONT14 Funding Number: CDC RFA OE13 130402CONT14 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Health Promotion and Disease Prevention Research Centers Special Interest Project Competitive Supplements (SIPs) Apply for RFA DP 14 0010101SUPP14 Funding Number: RFA DP 14 0010101SUPP14 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Research Approaches to Improve the Care and Outcomes of Apply for RFA DD 14 002 Funding Number: RFA DD 14 002 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $800,000 |
| Silvio O. Conte Centers for Basic or Translational Mental Health Research (P50) Apply for PAR 14 120 Funding Number: PAR 14 120 Agency: National Institutes of Health Category: Health Funding Amount: $2,000,000 |
| Consortium for Food Allergy Research (U19) Apply for RFA AI 14 003 Funding Number: RFA AI 14 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA AI 14 006", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.