Opportunity Information: Apply for RFA AI 11 018
Apply for RFA AI 11 018
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Innovation for HIV Vaccine Discovery (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jun 16, 2011 and posted on Jun 16, 2011.
- Applicants must submit their applications by Jan 6, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education County governments City or township governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses State governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
Innovation for HIV Vaccine Discovery (R01) is a National Institutes of Health discretionary grant opportunity (Funding Opportunity Number RFA-AI-11-018) designed to spark genuinely new thinking in HIV vaccine research. The central goal is to fund innovative, high-risk, high-impact early discovery projects that can uncover novel vaccine concepts, targets, and design strategies that ultimately support creation of an effective HIV immunogen capable of providing long-term protection against acquiring HIV. The emphasis is not on incremental improvements to existing approaches, but on research that introduces fresh ideas, including unconventional or "outside the box" vaccine concepts that could meaningfully change how HIV immunogens or immunization strategies are designed.
This FOA specifically targets the discovery stage of the vaccine pipeline, where foundational insights and new directions are generated rather than late-stage development or clinical testing. Projects are expected to contribute new concepts or targets that could open viable paths toward an effective HIV vaccine, such as identifying new immune responses to aim for, new ways to present viral components to the immune system, or new strategies for inducing durable protective immunity. The announcement also makes a point of lowering barriers to entry: applications are welcomed from both established and new investigators, and prior expertise in HIV prevention is not required. In practical terms, that invitation is meant to attract cross-disciplinary ideas and methods from fields that may not traditionally be centered in HIV vaccine development, potentially bringing in novel tools, models, or conceptual frameworks.
From an administrative standpoint, the award mechanism is an R01 research project grant, and the activity area sits within health research, tied to CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). The program does not require cost sharing or matching. NIH estimated total funding for this opportunity at about $3,000,000, with an award ceiling listed at $350,000. The opportunity was posted June 16, 2011, with an original and current closing date of January 6, 2012, and it was archived February 6, 2012.
Eligibility is broad and intentionally inclusive. Eligible applicants include small businesses; for-profit organizations (including those other than small businesses); nonprofits with or without 501(c)(3) status; public and private institutions of higher education; public and state-controlled universities; and a wide range of governmental entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly extends eligibility to groups often called out in NIH announcements, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, and eligible federal agencies. Importantly, it permits participation by non-U.S. entities (foreign organizations) and regional organizations, and it allows foreign (non-U.S.) components of U.S. organizations as well as U.S. territories or possessions, reflecting NIH interest in drawing from the global scientific community when it strengthens the science.
Overall, the opportunity is best understood as NIH asking researchers to take bold, creative swings at the earliest stages of HIV vaccine discovery, with the expectation that a relatively small number of breakthrough ideas can have outsized influence on the field. The full announcement was hosted on the NIH grants site under the provided link, and technical access issues were directed to the NIH Office of Extramural Research webmaster contact listed in the notice.
Frequently Asked Questions (FAQs): Innovation for HIV Vaccine Discovery (R01) - RFA-AI-11-018
What is the name of this funding opportunity?
The opportunity is titled Innovation for HIV Vaccine Discovery (R01).
What agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AI-11-018.
What is the main purpose of this FOA?
The central goal is to fund innovative, high-risk, high-impact early discovery research that can uncover novel HIV vaccine concepts, targets, and design strategies. The ultimate scientific aim is to support creation of an effective HIV immunogen capable of providing long-term protection against acquiring HIV.
What kind of research is NIH trying to encourage through this announcement?
The emphasis is on genuinely new thinking rather than incremental improvements. NIH is specifically looking for fresh, unconventional, or "outside the box" ideas that could meaningfully change how HIV immunogens or immunization strategies are designed.
Is this opportunity focused on early discovery or later-stage development?
This FOA specifically targets the discovery stage of the HIV vaccine pipeline, where foundational insights and new directions are generated. It is not positioned as a late-stage development or clinical testing opportunity based on the description provided.
What types of outcomes or contributions are projects expected to deliver?
Projects are expected to contribute new concepts or targets that could open viable paths toward an effective HIV vaccine. Examples described include identifying new immune responses to aim for, developing new ways to present viral components to the immune system, or proposing new strategies to induce durable protective immunity.
Does NIH want incremental improvements to existing HIV vaccine approaches?
No. The FOA explicitly emphasizes that it is not focused on incremental improvements to existing approaches, but instead on research introducing fresh ideas and potentially unconventional vaccine concepts.
What grant mechanism is used for this opportunity?
The award mechanism is an R01 research project grant.
What is the activity area or subject area for this funding?
The activity area is health research, associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Is cost sharing or matching required?
No. The program does not require cost sharing or matching.
How much total funding did NIH estimate for this opportunity?
NIH estimated total funding at approximately $3,000,000.
What is the award ceiling listed for this FOA?
The award ceiling is listed as $350,000.
When was this opportunity posted?
The opportunity was posted on June 16, 2011.
What was the closing date for applications?
The original and current closing date listed is January 6, 2012.
Is this funding opportunity still open?
No. The opportunity was archived on February 6, 2012, and the closing date provided is in 2012.
Who is eligible to apply?
Eligibility is described as broad and inclusive. Eligible applicants include:
- Small businesses
- For-profit organizations (including those other than small businesses)
- Nonprofits with or without 501(c)(3) status
- Public and private institutions of higher education
- Public and state-controlled universities
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public housing authorities / Indian housing authorities
Are specific types of institutions explicitly encouraged or included?
Yes. The FOA explicitly extends eligibility to groups commonly highlighted in NIH announcements, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian-serving institutions
- Faith-based or community-based organizations
- Eligible federal agencies
Are non-U.S. (foreign) organizations allowed to apply?
Yes. The FOA permits participation by non-U.S. entities (foreign organizations) and regional organizations.
Can U.S. organizations include foreign components in their projects?
Yes. The FOA allows foreign (non-U.S.) components of U.S. organizations.
Are U.S. territories or possessions included?
Yes. The FOA allows participation from U.S. territories or possessions.
Do applicants need prior expertise in HIV prevention to apply?
No. The FOA states that prior expertise in HIV prevention is not required, reflecting an effort to attract cross-disciplinary ideas and methods.
Are new investigators welcome, or is this mainly for established HIV vaccine researchers?
Applications are welcomed from both established and new investigators. The announcement is designed to lower barriers to entry and encourage cross-disciplinary participation.
Why does the FOA emphasize cross-disciplinary participation?
The description indicates NIH wants to draw in ideas, tools, models, and conceptual frameworks from fields that may not traditionally focus on HIV vaccine development, because that kind of cross-disciplinary thinking can generate genuinely novel vaccine concepts.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site under the provided link referenced in the notice.
Who should be contacted for technical access issues with the announcement?
The notice indicates technical access issues were directed to the NIH Office of Extramural Research webmaster contact listed in the announcement.
In one sentence, what is NIH asking researchers to do through this FOA?
NIH is asking researchers to take bold, creative swings at the earliest stages of HIV vaccine discovery, aiming for breakthrough ideas that could have an outsized impact on the field.
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