Opportunity Information: Apply for PAR 09 016
Apply for PAR 09 016
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Innovation in Molecular Imaging Probes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Nov 19, 2008 and posted on Nov 18, 2008.
- Applicants must submit their applications by Sep 21, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Innovation in Molecular Imaging Probes (R01) funding opportunity (PAR 09 016) is an NIH research grant announcement led by the National Institute of Biomedical Imaging and Bioengineering (NIBIB). It was released as a follow-on to an earlier NIH Roadmap solicitation (RM 04 021) and is aimed at pushing the field of molecular imaging beyond incremental improvements. The central idea is to support development of genuinely novel imaging probes and strategies that can visualize specific molecular activities inside living systems (in vivo), with a clear line of sight toward eventual clinical use. In practice, that means the program is looking for new ways to detect, track, or quantify molecular processes inside the body rather than simply producing another iteration of an existing probe type or imaging workflow.
The scientific goals are explicitly translational and framed around two long-term outcomes. One track is imaging the defining markers and functional behavior of normal cells in healthy volunteers and patients, which can help establish baselines for human biology and interpret what "normal" looks like across tissues and conditions. The second track is imaging disease-relevant markers and the biochemical or physiological abnormalities present in diseased cells in patients. The FOA highlights that early disease signals can show up as subtle molecular and cellular changes well before structural changes appear on conventional imaging, and it encourages proposals that can reveal those early shifts in a measurable, imageable way.
Examples of targetable abnormalities called out in the announcement include inflammation, fibrosis, immune cell activation, disruptions in signal transduction, altered gene expression pathways, and changes in post-translational protein modification. These examples are meant to illustrate the kind of biology the FOA has in mind: dynamic processes and pathway-level changes that could function as early biomarkers, help stratify disease, guide therapy selection, or provide rapid readouts of treatment response. The emphasis is less on any single disease area and more on the underlying molecular activities that are broadly relevant across many conditions.
In terms of what the NIH is trying to fund, the announcement draws a bright line between high-impact innovation and routine technology development. Projects are expected to explore creative approaches that could change what molecular imaging can do, not just optimize established chemistries, labels, or protocols already well supported through other NIH programs. While the FOA does not list every acceptable modality in the text provided, the intent is consistent with molecular imaging broadly, meaning applicants could potentially work across probe design, target biology, signal generation, delivery strategies, amplification mechanisms, and readout methods, as long as the end goal is imaging specific molecular activities in vivo and moving toward clinical relevance.
The mechanism is the standard NIH Research Project Grant (R01), with a 12-page limit for the research plan, which typically signals that reviewers will expect a tightly argued rationale, strong preliminary feasibility when appropriate, and a clear plan for execution. Funding levels and the number of awards are not fixed in the announcement; awards are contingent on available funds, and the total awarded as well as the number of funded projects will depend on the quality, proposed duration, and budget needs of the applications received. In other words, it is a competitive, merit-driven solicitation without a guaranteed set-aside amount disclosed in the summary.
Eligibility is broad and includes many types of organizations: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with certain distinctions), for-profit organizations (including small businesses and other for-profits), state governments, tribal governments and tribal organizations, and a variety of mission-focused institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities. The opportunity also allows non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions, indicating NIH interest in strong ideas regardless of geography, as long as applicants meet NIH requirements. There is no cost sharing or matching requirement.
Administratively, the FOA was posted in November 2008, with a closing date of September 21, 2011, and it is now archived (archive date October 22, 2011). The CFDA program numbers associated with the opportunity span multiple NIH research areas, reflecting the cross-cutting nature of molecular imaging and its relevance to mental health, technology development for human health, arthritis and skin diseases, diabetes and digestive and kidney diseases, neuroscience and neurological disorders, child health and human development, and aging research. The full announcement was hosted on the NIH grants site under the PAR 09 016 listing, and NIH provided standard webmaster contacts for access or linking problems.
Frequently Asked Questions (FAQs): Innovation in Molecular Imaging Probes (R01) - PAR 09 016
What is the Innovation in Molecular Imaging Probes (R01) opportunity (PAR 09 016)?
PAR 09 016 is an NIH research grant funding opportunity using the R01 mechanism, led by the National Institute of Biomedical Imaging and Bioengineering (NIBIB). It is focused on advancing molecular imaging by supporting development of genuinely novel imaging probes and strategies that can visualize specific molecular activities in living systems (in vivo), with a clear line of sight toward eventual clinical use.
Which NIH institute leads this funding opportunity?
The opportunity is led by the National Institute of Biomedical Imaging and Bioengineering (NIBIB).
How does PAR 09 016 relate to earlier NIH solicitations?
PAR 09 016 was released as a follow-on to an earlier NIH Roadmap solicitation (RM 04 021).
What is the main purpose of this FOA?
The main purpose is to push molecular imaging beyond incremental improvements by funding creative, high-impact approaches for imaging specific molecular processes in vivo, rather than funding routine iterations of existing probe types or established imaging workflows.
What does the FOA mean by "molecular imaging" in this context?
In this context, molecular imaging is framed as the ability to detect, track, or quantify specific molecular activities inside the body (in vivo). The FOA emphasizes imaging dynamic molecular processes and pathway-level changes, with an emphasis on translational relevance and eventual clinical use.
What are the long-term outcomes the FOA is aiming for?
The FOA frames two long-term outcome tracks: (1) imaging defining markers and functional behavior of normal cells in healthy volunteers and patients to establish baselines for human biology, and (2) imaging disease-relevant markers and biochemical or physiological abnormalities in diseased cells in patients.
Why does the FOA emphasize early disease signals?
The FOA notes that early disease signals can appear as subtle molecular and cellular changes well before structural changes are visible on conventional imaging. It encourages proposals that can reveal those early shifts in a measurable, imageable way.
What kinds of biological abnormalities or processes are specifically mentioned as examples?
Examples called out include inflammation, fibrosis, immune cell activation, disruptions in signal transduction, altered gene expression pathways, and changes in post-translational protein modification.
Is this opportunity limited to a specific disease area?
No. The emphasis is less on any single disease area and more on underlying molecular activities that are broadly relevant across many conditions.
What types of projects is NIH trying to fund under this announcement?
The announcement is looking for high-impact innovation in probe and strategy development that could change what molecular imaging can do. It is intended to support novel approaches to imaging specific molecular activities in vivo, with movement toward clinical relevance.
What kinds of projects are likely to be considered too incremental for this FOA?
The FOA draws a clear distinction between transformative innovation and routine technology development. It indicates it is not focused on simply optimizing established chemistries, labels, or protocols that are already well supported through other NIH programs.
Does the FOA restrict applicants to certain imaging modalities?
The text provided does not list every acceptable modality. The intent is consistent with molecular imaging broadly, and it suggests applicants could potentially work across probe design, target biology, signal generation, delivery strategies, amplification mechanisms, and readout methods, as long as the goal is imaging specific molecular activities in vivo and moving toward clinical relevance.
What grant mechanism is used for PAR 09 016?
The mechanism is the standard NIH Research Project Grant (R01).
What is the research plan page limit?
The research plan is limited to 12 pages.
What does a 12-page research plan limit imply about what reviewers may expect?
Based on the description provided, the page limit typically signals that reviewers will expect a tightly argued rationale, strong preliminary feasibility when appropriate, and a clear plan for execution.
Are funding levels or the number of awards fixed for this opportunity?
No. Funding levels and the number of awards are not fixed in the summary provided. Awards are contingent on available funds, and totals depend on the quality, duration, and budget needs of the applications received.
Is this a competitive, merit-driven opportunity?
Yes. The summary describes it as competitive and merit-driven, with no guaranteed set-aside amount disclosed.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with certain distinctions), for-profit organizations (including small businesses and other for-profits), state governments, tribal governments and tribal organizations, and a variety of mission-focused institutions (such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities).
Are non-U.S. organizations allowed to apply?
Yes. The opportunity allows non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions, indicating interest in strong ideas regardless of geography, as long as NIH requirements are met.
When was the FOA posted and when did it close?
The FOA was posted in November 2008 and had a closing date of September 21, 2011.
Is this funding opportunity still active?
No. It is archived, with an archive date of October 22, 2011.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site under the PAR 09 016 listing.
What CFDA program numbers are associated with this opportunity?
The CFDA program numbers associated with the opportunity span multiple NIH research areas, reflecting the cross-cutting nature of molecular imaging. The summary indicates relevance across areas including mental health, technology development for human health, arthritis and skin diseases, diabetes and digestive and kidney diseases, neuroscience and neurological disorders, child health and human development, and aging research.
Why are multiple CFDA areas associated with this FOA?
The summary suggests this is because molecular imaging is cross-cutting and relevant to multiple disease and research domains, so the associated CFDA program areas span a wide set of NIH missions.
What kinds of scientific impact does the FOA envision for successful probes and strategies?
The FOA highlights the potential for probes and imaging strategies to function as early biomarkers, help stratify disease, guide therapy selection, and provide rapid readouts of treatment response by measuring dynamic molecular and cellular changes in vivo.
Does the announcement mention any support contacts?
Yes. NIH provided standard webmaster contacts for access or linking problems related to the online announcement.
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