Opportunity Information: Apply for RFA ES 14 006
Apply for RFA ES 14 006
- The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "Innovative Approaches for the Identification of Mitochondria Cell Signaling Networks in Response to Environmental Stress" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health.
- This funding opportunity was created on Jun 11, 2014 and posted on Jun 11, 2014.
- Applicants must submit their applications by Sep 15, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses Special district governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Independent school districts Native American tribal governments (Federally recognized) State governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Private institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Innovative Approaches for the Identification of Mitochondria Cell Signaling Networks in Response to Environmental Stress" (Funding Opportunity Number RFA-ES-14-006) is a National Institutes of Health (NIH) discretionary grant program focused on advancing how researchers measure and interpret communication between mitochondria and the rest of the cell when cells are challenged by environmental stress. The core idea is that mitochondria do far more than produce energy; they also act as signaling hubs that influence nuclear responses and broader cellular programming. This FOA is aimed at building new tools and experimental systems that can track those signaling events with higher precision, particularly in contexts relevant to environmental health.
Scientifically, the FOA targets mitochondrial-to-nuclear and nuclear-to-mitochondrial communication pathways under stress conditions such as oxidative stress and related cellular insults. It specifically calls out interest in mitochondrial-nuclear signaling tied to epigenetic regulation, DNA damage response pathways, and reactions to oxidative stress, reflecting a broader goal of understanding how environmental exposures can rewire cellular behavior through mitochondrial signaling. The expectation is that improved detection methods and better models will allow investigators to map signaling networks more accurately, identify pathway alterations caused by environmental stressors, and connect those changes to downstream functional outcomes like altered gene expression programs, shifts in metabolism, or impaired mitochondrial performance.
A defining feature of the program is its use of the R21/R33 Phased Innovation Award mechanism. In practice, this means projects are structured in two stages. The first stage (R21) supports early development work, where investigators create or substantially improve technologies and experimental models. Examples highlighted in the FOA include more sensitive and specific reagents to detect particular reactive oxygen species (ROS) or reactive nitrogen species (RNS), stronger or more informative metabolic flux analysis approaches, and expanded in vitro or other experimental model systems that can reveal signaling pathway changes following exposure to environmental stressors. The R21 stage is milestone-driven: applicants are expected to define clear, measurable development goals that demonstrate the technology or model is feasible and performs as intended.
If those R21 milestones are met, projects may transition to the second stage (R33), which supports additional pilot testing and validation. The R33 phase is where the new tools are used more rigorously in environmental stress contexts to probe bidirectional communication between mitochondria and cellular control systems. The FOA emphasizes validation using environmental stressors to test whether the signaling readouts and model behaviors are robust, biologically meaningful, and capable of revealing how environmental challenges lead to either altered cellular programming, altered mitochondrial function, or both. In other words, the program is not only about building shiny new assays; it is about proving those assays can answer real environmental health questions in a reliable way.
From an administrative standpoint, this opportunity is categorized under environmental health (CFDA 93.113) and was posted June 11, 2014, with an original and current closing date of September 15, 2014, and an archive date of October 16, 2014. The estimated total funding amount listed is $3,000,000, and there is no cost sharing or matching requirement, which reduces barriers for applicants who may not have additional non-federal resources to commit.
Eligibility is broad and includes a wide range of organization types: for-profit entities (including small businesses and other for-profits), nonprofit organizations (including those with and without 501(c)(3) status), public and private institutions of higher education, and multiple levels of government (state, county, city/township, special district, and certain housing authorities). The FOA also explicitly includes a variety of mission- or community-focused institutions and entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal governments and tribally controlled colleges, Alaska Native and Native Hawaiian serving institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations and regional organizations, signaling an intent to encourage diverse participation and potentially international collaboration where appropriate.
Overall, this FOA is best understood as a technology- and model-development program with a clear environmental health application: enabling researchers to capture mitochondrial signaling networks in stressful exposure contexts with much greater clarity than standard methods allow. The phased structure is designed to push innovative but early-stage ideas through a disciplined development pipeline, moving from proof-of-concept tool creation in R21 to real-world validation and demonstration of utility in R33, with the end goal of strengthening the field's ability to link environmental stressors to mitochondrial signaling, cellular responses, and health-relevant biological outcomes.
Frequently Asked Questions (FAQs)
What is the full title of this grant opportunity?
The opportunity is titled "Innovative Approaches for the Identification of Mitochondria Cell Signaling Networks in Response to Environmental Stress."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-ES-14-006.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant program.
What is the main purpose of this FOA?
The FOA supports the development and validation of new tools, technologies, and experimental model systems to measure and interpret communication between mitochondria and the rest of the cell under environmental stress conditions. The emphasis is on capturing mitochondrial signaling events with higher precision in contexts relevant to environmental health.
Why does this FOA focus on mitochondria beyond energy production?
The FOA is grounded in the idea that mitochondria do more than produce energy; they function as signaling hubs that can influence nuclear responses and broader cellular programming, especially when cells are challenged by environmental stress.
What types of cellular communication does the FOA prioritize?
The FOA targets both mitochondrial-to-nuclear and nuclear-to-mitochondrial communication pathways, with a focus on how those pathways behave under stress.
What environmental stress contexts are specifically mentioned?
The FOA explicitly references oxidative stress and related cellular insults, and it emphasizes studying signaling changes following exposure to environmental stressors.
What biological themes or pathways are highlighted as areas of interest?
The FOA calls out particular interest in mitochondrial-nuclear signaling connected to epigenetic regulation, DNA damage response pathways, and cellular reactions to oxidative stress.
What kinds of outcomes is this program trying to connect mitochondrial signaling to?
The program aims to enable investigators to map signaling networks more accurately, identify pathway alterations caused by environmental stressors, and link those alterations to downstream functional outcomes such as altered gene expression programs, shifts in metabolism, or impaired mitochondrial performance.
What grant mechanism does this FOA use?
This FOA uses the R21/R33 Phased Innovation Award mechanism.
How does the R21/R33 phased structure work in this FOA?
Projects are designed in two stages. The first stage (R21) supports early development and substantial improvement of technologies and models. If R21 milestones are met, projects may transition to the second stage (R33), which supports additional pilot testing and validation of the new tools in environmental stress contexts.
What is the focus of the R21 phase?
The R21 phase supports proof-of-concept and development work, where investigators create or substantially improve technologies and experimental models intended to detect or characterize mitochondrial signaling events under environmental stress.
Is the R21 phase milestone-driven?
Yes. The FOA states that the R21 stage is milestone-driven, and applicants are expected to define clear, measurable development goals that demonstrate the technology or model is feasible and performs as intended.
What examples of R21-stage development are mentioned in the FOA?
Examples include more sensitive and specific reagents to detect particular reactive oxygen species (ROS) or reactive nitrogen species (RNS), improved or more informative metabolic flux analysis approaches, and expanded in vitro or other experimental model systems that can reveal signaling pathway changes following exposure to environmental stressors.
What is the focus of the R33 phase?
The R33 phase supports additional pilot testing and validation, using the newly developed tools and models more rigorously in environmental stress contexts to probe bidirectional communication between mitochondria and cellular control systems.
What does the FOA emphasize for validation in the R33 phase?
The FOA emphasizes validation using environmental stressors to assess whether signaling readouts and model behaviors are robust, biologically meaningful, and capable of revealing how environmental challenges lead to altered cellular programming, altered mitochondrial function, or both.
Is this FOA only about developing new assays and tools?
No. While technology and model development are central, the FOA also stresses demonstrating that the tools can reliably answer environmental health questions by validating them in relevant stressor contexts.
What is the CFDA number and program area for this opportunity?
The FOA is categorized under environmental health, CFDA 93.113.
When was this opportunity posted?
The posting date listed is June 11, 2014.
What were the closing dates for this FOA?
The original closing date and the current closing date are both listed as September 15, 2014.
When was the opportunity archived?
The archive date is October 16, 2014.
What is the estimated total funding amount?
The estimated total funding amount listed is $3,000,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes for-profit entities (including small businesses and other for-profits), nonprofit organizations (with and without 501(c)(3) status), public and private institutions of higher education, and multiple levels of government (state, county, city/township, special district, and certain housing authorities).
Are minority-serving institutions explicitly included as eligible?
Yes. The FOA explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal governments and tribally controlled colleges, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations as eligible applicants.
Are U.S. territories or possessions included in eligibility?
Yes. The FOA explicitly includes U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA explicitly includes non-U.S. (foreign) organizations and regional organizations as eligible.
What is the overall scientific and programmatic goal of this FOA?
The overall goal is to strengthen environmental health research by enabling more accurate mapping and interpretation of mitochondrial signaling networks under environmental stress, moving innovations from early-stage tool/model development (R21) to real-world validation and demonstration of utility (R33).
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