Opportunity Information: Apply for PAR 15 308
Apply for PAR 15 308
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research.
- This funding opportunity was created on Jul 24, 2015 and posted on Jul 24, 2015.
- Applicants must submit their applications by Jul 11, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Public and State controlled institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R01)" (Funding Opportunity Number PAR-15-308) is a National Institutes of Health (NIH) discretionary research grant that supports investigator-driven projects aimed at improving how cancer risks are identified and prevented by studying molecular "adducts." In this context, adducts are chemical modifications formed when reactive compounds produced by environmental exposures, lifestyle factors, diet, inflammation, or endogenous metabolism bind to cellular macromolecules such as DNA, RNA, proteins, or lipids. Because these adducts can serve as molecular footprints of exposure and early biological effect, the FOA emphasizes their potential value as indicators that connect what people are exposed to with mechanisms that may lead to cancer.
A central priority of the announcement is the use of adductomic approaches. Rather than measuring one or two well-known adducts, adductomics generally refers to broader, more comprehensive profiling that captures a wider spectrum of adducts, sometimes described as addressing part of the "totality" of adducts present in a biological system. The intent is to push basic research that can map, characterize, quantify, and interpret complex adduct patterns and relate them to cancer-relevant exposures and processes. Projects supported under this FOA are expected to strengthen foundational knowledge about adduct formation, persistence, repair or removal, and biological consequences, while also exploring how adduct profiles might eventually be useful for cancer detection, cancer prevention strategies, or more accurate assessment of cancer risk in individuals and populations.
The FOA is designed to be human-relevant. Proposed studies should focus on adducts that matter for humans and human populations, including exposures that are common or particularly important for public health. That said, applicants are allowed to use a wide range of experimental systems to answer these questions, including cultured cells, animal models, and other laboratory approaches, as long as the work clearly ties back to human relevance. The use of human biospecimens is encouraged and, when it makes scientific sense, is generally expected, but it is not an absolute requirement. This gives researchers flexibility to combine mechanistic model-based work with translational components such as measuring adducts in blood, urine, tissues, or other accessible specimens, or to develop and validate adductomic methods before deploying them broadly in population studies.
From an administrative and eligibility standpoint, this is an NIH R01 mechanism, meaning it is intended for substantial, hypothesis-driven or discovery-driven research projects rather than small pilot studies. The opportunity falls under multiple related CFDA program areas, including Environmental Health (93.113) and several cancer-focused research categories spanning cause and prevention, detection and diagnosis, and treatment research (93.393, 93.394, 93.395). There is no cost sharing or matching requirement, which typically makes the program more accessible to a broad range of institutions. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations other than small businesses, small businesses, and multiple levels of government (state and county). The eligibility scope is notably broad and also includes federally recognized and special-serving institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, AANAPISI institutions, U.S. territories or possessions, and even non-U.S. entities (foreign organizations), as well as eligible federal agencies.
In terms of timing and status, the FOA was posted and created on July 24, 2015, with an original and final closing date listed as July 11, 2018, and an archive date of August 11, 2018. That means the specific announcement is no longer open for new submissions under that solicitation, but it can still serve as a useful reference point for the kinds of adductomics and exposure-biomarker cancer research priorities NIH has supported. The full announcement was hosted through the NIH grants guide (link provided in the source data), and the NIH Office of Extramural Research (OER) webmaster contact is listed for technical access or linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R01)" and the Funding Opportunity Number (FOA) is PAR-15-308.
Which agency offers this funding opportunity?
This is a National Institutes of Health (NIH) discretionary research grant opportunity.
What type of grant mechanism is used?
The FOA uses the NIH R01 mechanism, which is intended for substantial research projects that can be hypothesis-driven and/or discovery-driven, rather than small pilot-style studies.
What is the main scientific focus of this FOA?
The FOA supports investigator-driven basic research aimed at improving how cancer risks are identified and prevented by studying molecular "adducts" and their relationship to exposures and cancer-relevant biological processes.
What are "adducts" in the context of this opportunity?
Adducts are chemical modifications that form when reactive compounds bind to cellular macromolecules such as DNA, RNA, proteins, or lipids. The reactive compounds can arise from environmental exposures, lifestyle factors, diet, inflammation, or endogenous metabolism.
Why are adducts important for cancer risk identification and prevention?
Adducts can serve as molecular footprints of exposure and early biological effect. They can help connect what people are exposed to with biological mechanisms that may contribute to cancer development, which may ultimately support better cancer risk assessment and prevention strategies.
What does the FOA mean by "adductomic" approaches?
Adductomics refers to broader, more comprehensive profiling of adducts rather than measuring only one or two well-known adducts. The idea is to capture a wider spectrum of adducts and interpret complex adduct patterns in relation to cancer-relevant exposures and processes.
Does this FOA require studying a single specific adduct?
No. A central priority is moving beyond targeted measurement of a small number of adducts and toward more comprehensive adductomic profiling that can characterize a broader set of adducts.
What kinds of research activities are encouraged under this FOA?
Projects are expected to strengthen foundational knowledge about adduct formation, persistence, repair or removal, and biological consequences, while also exploring how adduct profiles might eventually be useful for cancer detection, prevention strategies, or improved cancer risk assessment.
Is this FOA focused on human relevance?
Yes. The FOA is designed to be human-relevant, emphasizing adducts and exposures that matter for humans and human populations, particularly exposures common or important to public health.
Are applicants required to use human biospecimens?
The use of human biospecimens is encouraged and, when scientifically appropriate, is generally expected, but it is not an absolute requirement under the FOA.
What kinds of biospecimens are mentioned as examples?
Examples include measuring adducts in blood, urine, tissues, or other accessible specimens, depending on what best fits the scientific questions.
Can studies use model systems like cultured cells or animal models?
Yes. Applicants may use a wide range of experimental systems, including cultured cells, animal models, and other laboratory approaches, as long as the work clearly ties back to human relevance.
Can the FOA support method development for adductomics?
Yes. The FOA describes supporting basic research that can map, characterize, quantify, and interpret complex adduct patterns, including developing and validating adductomic methods before broader deployment in population studies.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Which program areas (CFDA) are associated with this FOA?
The opportunity falls under multiple CFDA program areas, including Environmental Health (93.113) and several cancer-focused categories spanning cause and prevention, detection and diagnosis, and treatment research (93.393, 93.394, 93.395).
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations other than small businesses, small businesses, and multiple levels of government (including state and county).
Are special-serving institutions included in eligibility?
Yes. The FOA explicitly includes federally recognized and special-serving institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, AANAPISI institutions, and entities in U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility scope includes non-U.S. entities (foreign organizations), and it also includes eligible federal agencies.
What were the posting and closing dates for this FOA?
The FOA was posted and created on July 24, 2015. The original and final closing date listed is July 11, 2018.
Is this funding opportunity still open?
No. The FOA is archived. An archive date of August 11, 2018 is listed, which indicates the specific announcement is no longer open for new submissions under that solicitation.
Does the archived FOA still have value for researchers?
Yes. While it is no longer open, it can still serve as a reference point for the kinds of adductomics, exposure-biomarker, and cancer risk identification and prevention priorities NIH has supported.
Where was the full announcement hosted?
The full announcement was hosted through the NIH grants guide (as referenced in the source information).
Who is listed as a contact for technical access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact is listed for technical access or linking issues: FBOWebmaster@OD.NIH.GOV.
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Applicants who have applied for this opportunity (PAR 15 308) also looked into and applied for these:
| Funding Opportunity |
|---|
| Translational Studies on Adducts for Cancer Risk Identification and Prevention (U01) Apply for PAR 15 307 Funding Number: PAR 15 307 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R21) Apply for PAR 15 309 Funding Number: PAR 15 309 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Superfund Basic Research and Training Program (P42) Apply for RFA ES 08 005 Funding Number: RFA ES 08 005 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $1,800,000 |
| Exploratory Innovations in Biomedical Computational Science and Technology (R21) Apply for PAR 06 411 Funding Number: PAR 06 411 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| The Role of Nuclear Receptors in Tissue and Organismal Aging (R21) Apply for PAS 06 466 Funding Number: PAS 06 466 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Understanding and Promoting Health Literacy(R21) Apply for PAR 07 018 Funding Number: PAR 07 018 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Structural Biology of Membrane Proteins (R01) Apply for PA 07 253 Funding Number: PA 07 253 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Networks and Pathways Collaborative Research Projects (R01) Apply for PA 07 266 Funding Number: PA 07 266 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| The Role of Nuclear Receptors in Tissue and Organismal Aging (R01) Apply for PAS 07 267 Funding Number: PAS 07 267 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Global Research Initiative Program, Behavioral/Social Sciences (R01) Apply for PAR 07 328 Funding Number: PAR 07 328 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $50,000 |
| Innovations in Biomedical Computational Science and Technology (R01) Apply for PAR 07 344 Funding Number: PAR 07 344 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Psychopharmacology of Widely Available Psychoactive Natural Products (R01) Apply for PA 07 374 Funding Number: PA 07 374 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Psychopharmacology Of Widely Available Psychoactive Natural Products (R03) Apply for PA 07 375 Funding Number: PA 07 375 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Predictive Multiscale Models of the Physiome in Health and Disease (R01) Apply for PAR 08 023 Funding Number: PAR 08 023 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Nanoscience and Nanotechnology in Biology and Medicine (R01) Apply for PA 08 052 Funding Number: PA 08 052 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Nanoscience and Nanotechnology in Biology and Medicine (R21) Apply for PA 08 053 Funding Number: PA 08 053 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R21) Apply for PA 08 141 Funding Number: PA 08 141 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk (R01) Apply for PA 08 140 Funding Number: PA 08 140 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Exploratory Collaborations with National Centers for Biomedical Computing (R21) Apply for PAR 08 183 Funding Number: PAR 08 183 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Collaborations with National Centers for Biomedical Computing (R01) Apply for PAR 08 184 Funding Number: PAR 08 184 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
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