Opportunity Information: Apply for RFA RM 10 001
Apply for RFA RM 10 001
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Institutional Clinical and Translational Science Award (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support 93.389 National Center for Research Resources.
- This funding opportunity was created on Jan 26, 2010 and posted on Jan 26, 2010.
- Applicants must submit their applications by Oct 14, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $20,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Institutional Clinical and Translational Science Award (CTSA) (U54) is a National Institutes of Health (NIH) funding opportunity designed to help institutions build a strong, integrated center for clinical and translational science. The main idea is to create an academic "home" that brings together the people, programs, and infrastructure needed to move discoveries more efficiently from basic research into real-world improvements in patient care and public health. This includes support for training and career development so that investigators can work effectively across disciplines, plus access to modern research tools, shared resources, and information technologies that speed up and strengthen the translational pipeline.
A central feature of the CTSA initiative is its emphasis on collaboration and connectivity. These awards are meant to pull together basic scientists, translational researchers, clinical investigators, community clinicians, and broader partners such as clinical practices, research networks, professional societies, and industry. By encouraging these groups to work in a coordinated way, CTSAs aim to spark new professional relationships and generate programs and research projects that might not happen within traditional departmental or siloed structures. Another stated goal is to advance clinical and translational science as a distinct discipline, supported in part through innovative advanced degree programs and other structured training approaches that go beyond narrow specialty boundaries.
The mechanism used for this program is a cooperative agreement specialized center award (U54). In practice, that means the NIH is not just providing funding and stepping back; it is signaling substantial programmatic involvement during the life of the award, consistent with how cooperative agreements are typically administered. Applicants should therefore expect an active relationship with NIH staff and a focus on meeting shared program goals and milestones, rather than operating with the autonomy typical of a standard research grant.
In terms of funding scale and competition, the announcement states that approximately $80 million is available for new awards under this solicitation, with up to 10 awards anticipated. The notice also makes clear that NIH intends to offer additional CTSA solicitations in future years, suggesting an ongoing national program rather than a one-time investment. The source record lists an estimated total funding figure of $20,000,000, but the narrative section emphasizes approximately $80 million available for the new awards; prospective applicants typically rely on the detailed funding language in the full FOA for the most authoritative interpretation of available funds and budgeting expectations.
Eligibility is broad and includes many types of organizations that can serve as hubs for clinical and translational research. Eligible applicants include public and private institutions of higher education, nonprofits (including and not limited to 501(c)(3) organizations), state governments, federally recognized tribal governments, and other tribal organizations. The opportunity also explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), regional organizations, and U.S. territories or possessions. For-profit organizations (other than small businesses) are also listed as eligible in the source data. The opportunity does not require cost sharing or matching.
Key administrative details from the record include the Funding Opportunity Number RFA-RM-10-001 and the title "Institutional Clinical and Translational Science Award (U54)." The opportunity category is discretionary, and the activity areas are education and health, with CFDA numbers 93.310 (Trans-NIH Research Support) and 93.389 (National Center for Research Resources). The posting and creation date were January 26, 2010, with an original and current closing date of October 14, 2010, and an archive date of November 14, 2010. The full announcement was made available through the NIH grants website, and the contact listed for access or linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs): Institutional Clinical and Translational Science Award (CTSA) (U54)
What is the Institutional Clinical and Translational Science Award (CTSA) (U54)?
The CTSA (U54) is a National Institutes of Health (NIH) funding opportunity intended to help institutions build a strong, integrated center for clinical and translational science. The program focuses on creating an academic "home" that brings together people, programs, and infrastructure to move research discoveries more efficiently from basic science into improvements in patient care and public health.
What is the main purpose of this CTSA funding opportunity?
The primary purpose is to support the creation and strengthening of an integrated institutional center that can accelerate and improve the translational pipeline, including the tools, shared resources, and information technologies needed to support clinical and translational research.
What does "clinical and translational science" mean in the context of this opportunity?
In this context, clinical and translational science refers to efforts that help move discoveries from basic research into real-world clinical applications and broader public health impact, supported by coordinated teams, infrastructure, and processes that increase efficiency and rigor along the way.
What types of activities or capabilities does the CTSA aim to support?
Based on the description provided, the CTSA aims to support training and career development, modern research tools, shared resources, and information technologies that help speed up and strengthen the overall translational process from discovery to practice.
How does training and career development fit into the CTSA program?
The opportunity includes support for training and career development so investigators can work effectively across disciplines. It also emphasizes innovative advanced degree programs and other structured training approaches that go beyond narrow specialty boundaries.
What is meant by creating an academic "home" for clinical and translational science?
It means building an integrated institutional center that serves as a hub where the people, programs, and infrastructure necessary for clinical and translational science are organized and coordinated, rather than being separated across traditional departmental or siloed structures.
Why does this program emphasize collaboration and connectivity?
Collaboration is described as a central feature of the CTSA initiative. The awards are intended to connect basic scientists, translational researchers, clinical investigators, community clinicians, and other partners so they can work in a coordinated way, form new professional relationships, and develop programs and research projects that might not emerge in more isolated environments.
Who are the intended collaborators and partners in a CTSA-supported program?
The description highlights collaboration among basic scientists, translational researchers, clinical investigators, community clinicians, and broader partners such as clinical practices, research networks, professional societies, and industry.
What funding mechanism is used for this opportunity?
The mechanism is a cooperative agreement specialized center award (U54).
What does it mean that this is a U54 cooperative agreement?
A U54 cooperative agreement indicates substantial programmatic involvement by NIH during the life of the award. In practice, applicants should expect an active relationship with NIH staff and an emphasis on meeting shared program goals and milestones, rather than operating with the autonomy typical of a standard research grant.
How much funding is expected to be available under this solicitation?
The narrative section states that approximately $80 million is available for new awards under this solicitation. The source record also lists an estimated total funding figure of $20,000,000. Prospective applicants typically rely on the detailed funding language in the full funding opportunity announcement (FOA) for the most authoritative interpretation of available funds and budgeting expectations.
How many awards does NIH anticipate making?
The announcement indicates that up to 10 awards are anticipated.
Is NIH expected to offer similar CTSA opportunities in the future?
Yes. The notice states that NIH intends to offer additional CTSA solicitations in future years, indicating this is part of an ongoing national program rather than a one-time investment.
Who is eligible to apply for this CTSA opportunity?
Eligibility is broad and includes: public and private institutions of higher education; nonprofits (including but not limited to 501(c)(3) organizations); state governments; federally recognized tribal governments; other tribal organizations; and for-profit organizations (other than small businesses), as listed in the source data.
Are minority-serving institutions and similar organizations included in eligibility?
Yes. The opportunity explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), as well as U.S. territories or possessions and regional organizations.
Are U.S. territories or possessions eligible applicants?
Yes. U.S. territories or possessions are explicitly included in the eligibility language provided.
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
What is the Funding Opportunity Number (FOA number) for this solicitation?
The Funding Opportunity Number is RFA-RM-10-001.
What is the official title of the opportunity?
The title is "Institutional Clinical and Translational Science Award (U54)."
What is the opportunity category?
The opportunity category is discretionary.
What activity areas are associated with this opportunity?
The activity areas listed are education and health.
Which CFDA numbers are associated with this opportunity?
The CFDA numbers listed are 93.310 (Trans-NIH Research Support) and 93.389 (National Center for Research Resources).
When was this opportunity posted, and what were the key dates?
The posting and creation date was January 26, 2010. The original and current closing date was October 14, 2010. The archive date was November 14, 2010.
Is this opportunity still open?
Based on the dates provided, the closing date was October 14, 2010, and the opportunity was archived on November 14, 2010.
Where was the full announcement made available?
The full announcement was made available through the NIH grants website.
Who should be contacted for access or linking issues related to the announcement?
The contact listed for access or linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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