Opportunity Information: Apply for RFA TR 12 006
Apply for RFA TR 12 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Institutional Clinical and Translational Science Award (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.350 National Center for Advancing Translational Sciences.
- This funding opportunity was created on Jul 6, 2012 and posted on Jul 6, 2012.
- Applicants must submit their applications by Jan 8, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $110,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) Special district governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses State governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Institutional Clinical and Translational Science Award (CTSA) (U54) is a National Institutes of Health (NIH) cooperative agreement designed to strengthen the full spectrum of translational research supported by NIH, from early-stage discoveries through clinical studies and into practices that can improve health outcomes. The core idea is to create or sustain an integrated institutional "home" for clinical and translational science that builds on an institution's existing strengths, connects people and resources that are often scattered across departments, and makes translational research more rigorous, efficient, and broadly applicable. In practical terms, the program emphasizes improving the quality, validity, generalizability, and overall efficiency of clinical and translational research, while also investing in workforce development and training so institutions can produce skilled translational scientists over the long term. This opportunity is described as the centerpiece of the National Center for Advancing Translational Sciences (NCATS) CTSA program, meaning it plays a central role in how NCATS advances national capacity for translational research infrastructure and expertise.
Administratively, this opportunity was issued as RFA-TR-12-006 under a discretionary funding category and uses the cooperative agreement mechanism (U54). A cooperative agreement signals that NIH expects substantial programmatic involvement beyond what is typical for a standard research grant, often including collaboration on priorities, milestones, and coordination with broader program goals. The activity category is Health, and the listing aligns with CFDA number 93.350 under NCATS. There is no cost sharing or matching requirement, which generally lowers barriers for eligible organizations that may not have discretionary funds to meet a match.
The funding opportunity was posted and created on July 6, 2012, with an original and current closing date of January 8, 2013, and an archive date of February 8, 2013. The estimated total funding amount is listed as $110,000,000, indicating a large national investment intended to support multiple awardees and significant infrastructure, training activities, and institutional capacity building. Because the CTSA model centers on institutional platforms, these awards typically support shared resources, research support services, and training structures rather than only single, stand-alone research projects.
Eligibility is broad across public, private, nonprofit, and governmental entities within the United States and its territories, reflecting the program's goal of strengthening translational research capacity across a wide range of institutions and communities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits both with and without 501(c)(3) status (excluding institutions of higher education in that specific clause), for-profit organizations other than small businesses, small businesses, and various local and state governmental units such as county governments, city or township governments, and special district governments. The announcement also explicitly includes tribal and tribal-serving entities and related organizations, including federally recognized Native American tribal governments, other tribal governments, tribal organizations, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. Additional eligible categories listed include historically Black colleges and universities (HBCUs), Hispanic-serving institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government. At the same time, the opportunity clearly excludes non-U.S. entities: foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed, which keeps the work and infrastructure development anchored within eligible U.S.-based institutions.
For applicants seeking the full official announcement and requirements, the opportunity provides an additional information link to the NIH grants page for RFA-TR-12-006. For access issues or technical problems reaching the announcement, the contact point is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: Institutional Clinical and Translational Science Award (CTSA) (U54)
What is the Institutional Clinical and Translational Science Award (CTSA) (U54)?
The CTSA (U54) is a National Institutes of Health (NIH) cooperative agreement intended to strengthen the full spectrum of NIH-supported translational research, from early-stage discoveries through clinical studies and into practices that can improve health outcomes.
What is the main purpose of this CTSA opportunity?
The purpose is to create or sustain an integrated institutional "home" for clinical and translational science by building on an institution's existing strengths, connecting people and resources that may be spread across departments, and making translational research more rigorous, efficient, and broadly applicable.
What parts of translational research does the program aim to support?
This opportunity is designed to support the full continuum of translational research supported by NIH, spanning early discoveries, clinical studies, and translation into practices that improve health outcomes.
What does "integrated institutional home" mean in this context?
It refers to an institutional platform that organizes and integrates clinical and translational science efforts, bringing together people, programs, and resources that may otherwise be scattered across departments, so that translational research can be supported in a coordinated way.
How does this program aim to improve clinical and translational research?
The program emphasizes improving the quality, validity, generalizability, and overall efficiency of clinical and translational research.
Does this opportunity include training and workforce development?
Yes. A stated emphasis is workforce development and training so institutions can produce skilled translational scientists over the long term.
Which NIH center leads this opportunity?
This opportunity is described as the centerpiece of the National Center for Advancing Translational Sciences (NCATS) CTSA program.
What is the funding opportunity announcement identifier?
The opportunity was issued as RFA-TR-12-006.
What funding mechanism is used (and what does it imply)?
The mechanism is a cooperative agreement (U54). A cooperative agreement indicates NIH expects substantial programmatic involvement beyond what is typical for a standard research grant, often including collaboration on priorities, milestones, and coordination with broader program goals.
What is the activity category for this opportunity?
The activity category is Health.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What is the estimated total funding amount?
The estimated total funding amount is $110,000,000.
When was the opportunity posted?
The funding opportunity was posted and created on July 6, 2012.
What are the closing and archive dates listed?
The original and current closing date is January 8, 2013, and the archive date is February 8, 2013.
What types of activities do CTSA awards typically support?
Because the CTSA model centers on institutional platforms, these awards typically support shared resources, research support services, and training structures rather than only single, stand-alone research projects.
Who is eligible to apply?
Eligibility includes a wide range of U.S.-based entities, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, excluding institutions of higher education in that specific clause), for-profit organizations other than small businesses, small businesses, and various government entities (including county, city or township, and special district governments).
Are tribal and tribal-serving organizations eligible?
Yes. The eligibility list explicitly includes federally recognized Native American tribal governments, other tribal governments, tribal organizations, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are specific higher-education institution types (like HBCUs and Hispanic-serving institutions) included?
Yes. The eligibility list includes historically Black colleges and universities (HBCUs), Hispanic-serving institutions, and Alaska Native and Native Hawaiian Serving Institutions.
Are faith-based or community-based organizations eligible?
Yes. The eligible categories explicitly include faith-based or community-based organizations.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicants.
Are federal government agencies eligible to apply?
Yes. The eligible categories include eligible agencies of the federal government.
Are foreign organizations or foreign components allowed?
No. The opportunity excludes non-U.S. entities: foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
What CFDA number is associated with this listing?
The listing aligns with CFDA number 93.350 under NCATS.
Where can applicants find the official announcement?
The opportunity provides an additional information link to the NIH grants page for RFA-TR-12-006.
Who should be contacted for technical problems accessing the announcement?
For access issues or technical problems reaching the announcement, the contact point is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
How is this opportunity categorized administratively?
It was issued under a discretionary funding category and uses the cooperative agreement mechanism (U54).
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