Opportunity Information: Apply for RFA RR 10 009

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Instrument Development for Biomedical Applications (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.389 National Center for Research Resources.
  • This funding opportunity was created on Jul 23, 2010 and posted on Jul 23, 2010.
  • Applicants must submit their applications by Oct 8, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $125,000.00 in funding.
  • Eligible applicants include: Public and State controlled institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Small businesses For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Eligible Agencies of the Federal Government.
Apply for RFA RR 10 009

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Opportunity Summary:

Instrument Development for Biomedical Applications (R21) is a National Institutes of Health (NIH) funding opportunity issued by the National Center for Research Resources (NCRR) to support early-stage, innovative work on creating new or improved biomedical research instruments. The main goal is to move beyond incremental upgrades and instead encourage fresh instrument concepts, prototypes, or enabling technologies that can broadly accelerate biomedical or clinical research. A key emphasis is general usefulness: proposed tools should be applicable to a wide range of researchers and research questions rather than being designed only for a single organ system, disease area, or narrowly defined application.

The program uses the NIH Exploratory/Developmental Grant mechanism (R21), which is typically intended for high-impact, early development projects where the idea is promising but still needs proof-of-concept or prototype-level validation. In practical terms, this mechanism fits projects focused on designing, building, integrating, and initially testing instrumentation, including demonstrating feasibility and performance in a research-relevant setting. The announcement frames the work around instrumentation development specifically for biomedical research, meaning the deliverable is expected to be a tangible tool, platform, or device capability that improves how research is performed, measured, imaged, analyzed, or otherwise enabled.

From a funding and awards standpoint, NCRR planned to allocate about $1,000,000 total for this initiative and anticipated making roughly five to eight awards in fiscal year 2011, contingent on the availability of funds and the quality and volume of applications received. The listed award ceiling is $125,000. The opportunity was posted on July 23, 2010, with an application closing date of October 8, 2010, and an archive date of November 8, 2010, indicating it is no longer open but remains available as a historical reference for similar NIH instrument-development solicitations.

Eligibility is broad and includes many organization types that commonly participate in NIH funding. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both those with and without 501(c)(3) status), state governments, small businesses, and for-profit organizations other than small businesses. The announcement also notes that other eligible applicants include certain federal government agencies. No cost sharing or matching is required, which lowers barriers for applicants who may not have discretionary funds to contribute alongside federal support.

Administratively, this is a discretionary grant opportunity in the education and health activity area (CFDA 93.389) and is identified by Funding Opportunity Number RFA RR 10 009. The full announcement and official instructions were provided through the NIH Grants Guide at the linked NIH page. For technical issues accessing the announcement or linking problems, the contact listed is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).

Instrument Development for Biomedical Applications (R21) - FAQs

What is the "Instrument Development for Biomedical Applications (R21)" opportunity?

It is a National Institutes of Health (NIH) funding opportunity issued by the National Center for Research Resources (NCRR) to support early-stage, innovative development of new or improved biomedical research instruments.

Which NIH component issued this opportunity?

The opportunity was issued by the National Center for Research Resources (NCRR) under the NIH.

What is the main goal of this grant program?

The main goal is to encourage fresh instrument concepts, prototypes, or enabling technologies that go beyond incremental upgrades and can broadly accelerate biomedical or clinical research.

What kinds of projects are emphasized as a priority?

The emphasis is on early-stage, innovative instrument development, including creating, integrating, and initially testing instrumentation and demonstrating feasibility and performance in a research-relevant setting.

What does the program mean by "moving beyond incremental upgrades"?

It means the program is looking for novel instrument concepts or enabling technologies rather than small, routine improvements to existing tools.

Does the instrument need to be broadly useful, or can it be tailored to one disease or organ system?

A key emphasis is general usefulness. Proposed tools should be applicable to a wide range of researchers and research questions, not designed only for a single organ system, disease area, or narrowly defined application.

What grant mechanism is used for this opportunity?

The opportunity uses the NIH Exploratory/Developmental Grant mechanism (R21).

What is the R21 mechanism intended to support in this context?

In this announcement, the R21 is positioned for high-impact, early development projects where an idea is promising but still needs proof-of-concept or prototype-level validation.

What types of deliverables are expected from funded projects?

The announcement frames the work around instrumentation development for biomedical research, with an expectation of a tangible tool, platform, or device capability that improves how research is performed, measured, imaged, analyzed, or otherwise enabled.

How much total funding was planned for this initiative?

NCRR planned to allocate about $1,000,000 total for the initiative.

How many awards were anticipated?

Roughly five to eight awards were anticipated in fiscal year 2011, contingent on the availability of funds and the quality and volume of applications received.

What is the listed award ceiling?

The listed award ceiling is $125,000.

When was the opportunity posted?

It was posted on July 23, 2010.

What was the application closing date?

The application closing date was October 8, 2010.

What does the archive date indicate?

The archive date (November 8, 2010) indicates the opportunity is no longer open and remains available as a historical reference for similar NIH instrument-development solicitations.

Is this funding opportunity currently open?

No. Based on the closing and archive dates provided, it is no longer open.

Who was eligible to apply?

Eligibility was broad and included public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both those with and without 501(c)(3) status), state governments, small businesses, and for-profit organizations other than small businesses. Certain federal government agencies were also noted as eligible applicants.

Are nonprofits without 501(c)(3) status eligible?

Yes. The eligibility list includes nonprofit organizations with and without 501(c)(3) status.

Are for-profit organizations eligible?

Yes. For-profit organizations other than small businesses are included as eligible applicants, and small businesses are also explicitly listed as eligible.

Are state governments eligible to apply?

Yes. State governments are included in the list of eligible applicants.

Are federal government agencies eligible to apply?

The announcement notes that certain federal government agencies are among the other eligible applicants.

Is cost sharing or matching required?

No. The opportunity states that no cost sharing or matching is required.

What is the activity area for this opportunity?

It is described as a discretionary grant opportunity in the education and health activity area.

What is the CFDA number associated with this program?

The CFDA number listed is 93.389.

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is RFA RR 10 009.

Where were the official announcement and instructions provided?

The full announcement and official instructions were provided through the NIH Grants Guide at the linked NIH page referenced in the opportunity description.

Who is the contact for technical issues accessing the announcement or for linking problems?

The contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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