Integrated Preclinical/Clinical Program for HIV Topical Microbicides (IPCP HTM) Competitive Revisions (U19) | Apply Online

Opportunity Summary:

The grant opportunity titled "Integrated Preclinical/Clinical Program for HIV Topical Microbicides (IPCP HTM) Competitive Revisions (U19)" (Funding Opportunity Number RFA-AI-10-007) is a National Institutes of Health announcement led by NIAID, with involvement anticipated from NIMH, that offers existing IPCP HTM U19 cooperative agreement grantees a chance to compete for additional funds to expand the scope of their currently funded projects. Rather than supporting brand-new centers, this FOA is specifically designed for current NIAID IPCP HTM awardees who want to add substantial new work to their ongoing, multi-project programs in a way that strengthens the overall effort and accelerates progress toward HIV prevention tools.

The underlying IPCP HTM program focuses on topical microbicides and microbicide combination strategies intended to prevent HIV transmission. The scientific emphasis is on advancing candidates that are not only biologically promising, but also safe, effective, and acceptable for real-world use. The program structure encourages multi-project, multidisciplinary teams that can span the full translational spectrum, linking preclinical development work with exploratory clinical studies. In practice, that means the supported efforts can integrate activities like formulation development, laboratory and animal model testing, safety and toxicity assessments, mechanism-of-action work, and early clinical evaluations that help determine whether a candidate is ready for larger-scale testing.

This particular FOA supports "competitive revisions," which are best understood as competitively reviewed expansions to an existing award. The intent is to let established IPCP HTM teams address important gaps that have emerged, take advantage of timely opportunities, or add new research directions that materially strengthen the funded program. Applicants are expected to propose work that clearly expands the scope of their current IPCP HTM award, rather than simply continuing what is already funded. Because these are cooperative agreements (U19), the relationship between the awardee and NIH typically involves substantial programmatic involvement from the funding institute compared to a standard grant, reflecting the complexity and coordination needs of multi-component translational programs.

In terms of funding, NIAID and NIMH projected a combined total of about $6,000,000 in FY 2011 to support awards made under this competitive revision FOA (RFA-AI-10-007) together with applications submitted to a separate, closely timed companion FOA for new IPCP HTM awards (RFA-AI-10-006), which has the same scientific scope but is intended for new awards rather than expansions. At least one award was anticipated. The listed award ceiling for this opportunity is $1,400,000. There is no cost sharing or matching requirement.

Eligibility is narrow and targeted: the eligible institutions are current NIAID IPCP HTM awardees, meaning only existing program grantees can apply for these competitive revisions. The opportunity falls under NIH health-related research funding and is associated with CFDA numbers 93.242 (Mental Health Research Grants), 93.855 (Allergy, Immunology and Transplantation Research), and 93.856 (Microbiology and Infectious Diseases Research), reflecting the interdisciplinary nature of microbicide research and its relevance across infectious disease, immunology, and behavioral or mental health dimensions tied to prevention uptake and acceptability.

Administratively, the FOA was posted on August 2, 2010, with an application closing date of November 17, 2010, and an archive date of December 18, 2010. Additional details and the full text were made available through the NIH Grants Guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-007.html), and the NIH Office of Extramural Research webmaster contact was listed for access or linking issues.

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