Opportunity Information: Apply for DE PS02 09ER09 08
Apply for DE PS02 09ER09 08
- The Chicago Service Center in the science and technology and other research and development sector is offering a public funding opportunity titled "Integrated Radiochemistry Research Projects of Excellence" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 81.049 Office of Science Financial Assistance Program.
- This funding opportunity was created on Mar 5, 2009 and posted on Jan 12, 2009.
- Applicants must submit their applications by Apr 2, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
- All types of domestic entities are eligible to apply, except other Federal agencies, Federally Funded Research and Development Center (FFRDC) Contractors, and nonprofit organizations described in section 501(c)(4) of the Internal Revenue Code of 1986 that engaged in lobbying activities after December 31, 1995.
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Opportunity Summary:
The Integrated Radiochemistry Research Projects of Excellence grant opportunity is a U.S. Department of Energy (DOE) Office of Science funding announcement issued through the Office of Biological and Environmental Research (BER). It supports fundamental radiochemistry research that advances DOE missions in energy, the environment, and basic science, while also strengthening the training pipeline for the next generation of radiochemists. The program is structured around the idea that high-impact method development in radiolabeling and radiotracer chemistry should be tightly coupled to hands-on graduate student and postdoctoral training, so that technical progress and workforce development happen together rather than separately.
On the research side, BER is looking for projects that improve the chemistry and technology behind radiolabeled probes and radiotracers, especially in areas that enable better imaging and quantitative measurement of biological and chemical processes. The announcement highlights four priority directions: developing new chemical reactions that enable high-specific-activity probe synthesis; creating models that help scientists understand and predict chemical reactivity when working at tracer-level masses (where the chemistry can behave differently than it does at conventional scales); designing nanoparticle-based platforms that can incorporate one or more imaging agents; and building or improving automation technologies for radiotracer synthesis. Collectively, these topics point to an emphasis on practical, scalable, and reproducible radiochemistry methods that can expand what is measurable in complex systems.
A central goal is also training. BER explicitly wants projects that embed graduate students and postdoctoral researchers directly into the core research effort, expanding radiochemistry training opportunities and helping ensure long-term availability of skilled personnel. The intended impact is broad: the resulting radiotracer methodologies should support BER-relevant biological research tied to energy and environmental questions, while also contributing to technological advances that matter in nuclear medicine research. In other words, projects are expected to generate foundational tools and methods that can be used both for DOE mission needs and for wider biomedical imaging and tracer-based measurement applications.
The opportunity expects applicants to demonstrate that they can support this kind of integrated research-and-training environment. Competitive projects must have access to existing advanced facilities and be built around an interdisciplinary, collaborative team. The announcement specifically calls for teams that include nuclear chemists, radiochemists, synthetic chemists, and biochemists, reflecting the reality that modern radiotracer development spans radionuclide production, synthetic methodology, purification and formulation, and biological validation. Beyond internal capabilities, the institutional setting is expected to offer broad collaboration opportunities with other investigators funded by federal agencies and/or the private sector. The DOE is clearly signaling that projects should sit within a larger ecosystem where methods can be developed, tested, translated, and applied.
The program also emphasizes connecting the full chain from radionuclide production to real biological application. It encourages settings where radionuclide production research can be linked to incorporation of radioisotopes into a wide range of organic molecules for probe development, and where those probes can then be used for quantitative in vivo measurements. The types of measurements described include site-specific (in situ) chemical reactions, how those reactions are altered by metabolism, and what biological processes follow from those perturbations. That framing suggests BER is interested not only in making new tracers, but in enabling rigorous, quantitative experiments that reveal mechanism and dynamics in living systems.
Administratively, this is a discretionary grant opportunity under the Office of Science Financial Assistance Program (CFDA 81.049), with no cost sharing requirement. Eligibility is broadly open to domestic entities, with exclusions for other federal agencies, Federally Funded Research and Development Center (FFRDC) contractors, and certain 501(c)(4) nonprofit organizations that engage in lobbying activities. The funding opportunity number is DE-PS02-09ER09-08, it was posted January 12, 2009, and the application deadline listed is April 2, 2009 (with the opportunity later archived May 12, 2010). For access issues or help navigating the announcement, the notice provides DOE assistance contacts, including the IIPS HelpDesk (iipshelpdesk@e-center.doe.gov) and a program contact, Deborah Greenawalt (Deb.Greenawalt@science.doe.gov).
Integrated Radiochemistry Research Projects of Excellence (DOE Office of Science/BER) - FAQs
What is the Integrated Radiochemistry Research Projects of Excellence funding opportunity?
It is a U.S. Department of Energy (DOE) Office of Science funding announcement issued through the Office of Biological and Environmental Research (BER) that supports fundamental radiochemistry research aligned with DOE missions in energy, the environment, and basic science. A defining feature is that research advances are expected to be tightly integrated with hands-on training of graduate students and postdoctoral researchers.
Which DOE office is sponsoring this opportunity?
The opportunity is issued by the DOE Office of Science through the Office of Biological and Environmental Research (BER).
What is the main purpose of this program?
The program is designed to advance high-impact radiochemistry method development (especially radiolabeling and radiotracer chemistry) while simultaneously strengthening the workforce pipeline by embedding graduate student and postdoctoral training directly into the core research effort.
What kinds of research does BER want to support under this announcement?
BER is looking for projects that improve the chemistry and enabling technology behind radiolabeled probes and radiotracers, particularly methods that lead to better imaging and quantitative measurement of biological and chemical processes.
What priority research directions are highlighted in the announcement?
The announcement highlights four priority directions:
- Developing new chemical reactions that enable high-specific-activity probe synthesis
- Creating models to understand and predict chemical reactivity at tracer-level masses (where chemistry can behave differently than at conventional scales)
- Designing nanoparticle-based platforms that can incorporate one or more imaging agents
- Building or improving automation technologies for radiotracer synthesis
What does "high-specific-activity" probe synthesis mean in the context of this opportunity?
Based on the announcement focus, it refers to radiolabeling methods that enable synthesis of probes with high radioactivity per amount of material, supporting sensitive imaging and quantitative measurements where tracer quantities are used.
Why does the announcement emphasize tracer-level masses?
The notice points out that chemistry at tracer-level masses can behave differently than chemistry at conventional scales. BER is therefore interested in models that help scientists understand and predict reactivity under tracer-scale conditions, which is central to reliable radiotracer development and application.
How do nanoparticle-based platforms fit into the program priorities?
The announcement calls out nanoparticle-based platforms as a priority direction, specifically platforms designed to incorporate one or more imaging agents. This aligns with the broader aim of improving radiolabeled probes and radiotracers for imaging and quantitative measurement.
What is the role of automation in projects funded under this program?
Automation technologies for radiotracer synthesis are explicitly listed as a priority area. The emphasis across the announcement suggests interest in practical, scalable, and reproducible methods, and automation can help standardize and improve radiotracer production workflows.
Is this opportunity only about developing new tracers, or also about using them in biology?
It is about both. The opportunity emphasizes connecting the full chain from radionuclide production to incorporation into organic molecules for probe development and then to quantitative in vivo measurements. The framing suggests BER is interested in enabling rigorous, quantitative experiments that reveal mechanism and dynamics in living systems, not only in producing new tracers.
What types of biological measurements does the announcement describe?
The notice describes quantitative in vivo measurements including site-specific (in situ) chemical reactions, how those reactions are altered by metabolism, and what biological processes follow from those perturbations.
How does this opportunity relate to DOE mission needs?
The announcement states that funded radiotracer methodologies should support BER-relevant biological research tied to energy and environmental questions while also advancing DOE missions in energy, the environment, and basic science.
Does the program mention relevance beyond DOE, such as medical applications?
Yes. The notice states that the resulting radiotracer methodologies are also expected to contribute to technological advances that matter in nuclear medicine research, indicating broader relevance to biomedical imaging and tracer-based measurement applications.
What is meant by an "integrated research-and-training environment" in this program?
It refers to projects where method development in radiochemistry is directly coupled to hands-on training of graduate students and postdoctoral researchers, so that technical progress and workforce development occur together.
Are graduate students and postdoctoral researchers expected to be involved?
Yes. Training is a central goal, and BER explicitly wants projects that embed graduate students and postdoctoral researchers directly into the core research effort to expand radiochemistry training opportunities and help ensure long-term availability of skilled personnel.
What team composition does DOE/BER expect for competitive proposals?
The announcement specifically calls for interdisciplinary, collaborative teams that include nuclear chemists, radiochemists, synthetic chemists, and biochemists, reflecting the end-to-end needs of radiotracer development and validation.
What capabilities or resources are expected for competitive projects?
Competitive projects are expected to have access to existing advanced facilities and to be built around an interdisciplinary, collaborative team. The institutional setting is also expected to offer broad collaboration opportunities with other investigators funded by federal agencies and/or the private sector.
Why does the announcement emphasize linking radionuclide production to biological application?
The program encourages settings where radionuclide production research can be linked to incorporation of radioisotopes into a wide range of organic molecules for probe development, and where those probes can then be used for quantitative in vivo measurements. This indicates BER wants end-to-end capability from isotope production through real biological use.
What is the CFDA number associated with this opportunity?
The opportunity is under the Office of Science Financial Assistance Program with CFDA 81.049.
Is this a discretionary grant, and is cost sharing required?
It is described as a discretionary grant opportunity, and the notice states there is no cost sharing requirement.
Who is eligible to apply?
Eligibility is broadly open to domestic entities, with exclusions listed for other federal agencies, Federally Funded Research and Development Center (FFRDC) contractors, and certain 501(c)(4) nonprofit organizations that engage in lobbying activities.
Which applicants are specifically excluded from eligibility?
The notice excludes other federal agencies, FFRDC contractors, and certain 501(c)(4) nonprofit organizations that engage in lobbying activities.
What is the funding opportunity number?
The funding opportunity number is DE-PS02-09ER09-08.
When was the opportunity posted, and what was the application deadline?
It was posted on January 12, 2009, and the listed application deadline is April 2, 2009.
Is this opportunity still active?
The notice states the opportunity was later archived on May 12, 2010.
Who can applicants contact for help with access issues or navigating the announcement?
The notice provides DOE assistance contacts including the IIPS HelpDesk (iipshelpdesk@e-center.doe.gov) and a program contact, Deborah Greenawalt (Deb.Greenawalt@science.doe.gov).
What is the IIPS HelpDesk email listed in the announcement?
The IIPS HelpDesk email is iipshelpdesk@e-center.doe.gov.
Who is the program contact listed, and what is their email?
The program contact listed is Deborah Greenawalt, and the email provided is Deb.Greenawalt@science.doe.gov.
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