Opportunity Information: Apply for PA 07 135
Apply for PA 07 135
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Integrating Lung Genetics and Genomics in Human Populations (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 12, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Special district governments Public housing authorities/Indian housing authorities City or township governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) County governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
- Foreign institutions are not eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH grant opportunity "Integrating Lung Genetics and Genomics in Human Populations (R01)" (Funding Opportunity Number PA-07-135) is a discretionary health research funding announcement aimed at pushing forward the discovery of genes involved in complex human lung disease traits. The central goal is to encourage research projects that do not rely on genetics or genomics alone, but instead combine them in innovative ways to better identify, validate, and understand genetic factors that contribute to lung diseases in human populations. In practical terms, the opportunity is geared toward studies that integrate approaches such as human genetic association methods with broader genomic tools and datasets, with the expectation that this combined strategy will be more powerful for complex, multi-factorial lung conditions where many genes and environmental influences may be involved.
This funding uses the NIH Research Project Grant (R01) mechanism, which generally supports hypothesis-driven, investigator-initiated research projects and is commonly used for multi-year biomedical studies with clear specific aims and a defined research plan. The announcement does not set a single fixed award size or project period. Instead, NIH indicates that budgets and durations are expected to vary depending on what each application proposes, since the scientific scope and resource needs could differ widely from one project to another. Likewise, NIH does not commit to a specific number of awards or a single total set-aside amount in the text provided; the number and size of awards will ultimately depend on the availability of funds and, importantly, the scientific quality, feasibility, duration, and cost of the applications that are submitted and selected for funding.
The opportunity is categorized under CFDA 93.838 (Lung Diseases Research) and is administered by the National Institutes of Health. It explicitly states there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving the award. Receipt is structured around multiple due dates rather than one deadline, with applicants directed to the full announcement for the specific schedule and instructions, reflecting NIH's common practice of using standard recurring submission cycles for many program announcements.
Eligibility is broad across U.S.-based organizational types and includes many nonprofit and governmental entities as well as certain for-profit organizations. Eligible applicants include 501(c)(3) nonprofits (and certain nonprofits without 501(c)(3) status), public and private institutions of higher education, small businesses, state and local governments (including counties, cities/townships, special district governments, and independent school districts), public housing authorities/Indian housing authorities, Native American tribal governments (federally recognized), and Native American tribal organizations (other than federally recognized tribal governments). The announcement also notes that eligible federal government agencies may apply, and that faith-based or community-based organizations are eligible. A key restriction is that foreign institutions are not eligible to apply, which means the applicant organization must be U.S.-based even if research collaborations include international components (any such arrangements would need to fit within NIH policy and the specific rules in the full announcement).
For applicants looking to assess fit, the essence of the FOA is the expectation of integration: projects should meaningfully merge genetic and genomic strategies to uncover genes linked to complex lung disease traits in humans. Competitive applications would typically be expected to articulate why an integrated approach is necessary, how genetic findings will be strengthened by genomic evidence (or vice versa), and how the proposed work will improve understanding of disease mechanisms, risk stratification, or biological pathways relevant to lung health. The full text of the announcement is available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-07-135.html, and NIH provides webmaster contacts for technical issues accessing or linking to the posting (FBOWebmaster@OD.NIH.GOV).
FAQs: Integrating Lung Genetics and Genomics in Human Populations (R01) - NIH (PA-07-135)
What is the name of this NIH grant opportunity?
The opportunity is titled "Integrating Lung Genetics and Genomics in Human Populations (R01)." The Funding Opportunity Number is PA-07-135.
What is the main purpose of PA-07-135?
The central purpose is to advance discovery of genes involved in complex human lung disease traits by encouraging research that integrates both genetics and genomics in human populations. The emphasis is on combined approaches that improve identification, validation, and understanding of genetic factors contributing to lung diseases.
What type of research approach does this FOA encourage?
This FOA encourages studies that do not rely on genetics or genomics alone. Instead, it prioritizes projects that meaningfully integrate human genetic association methods with broader genomic tools and datasets, because complex lung conditions may involve many genes plus environmental influences.
What makes this opportunity different from a genetics-only or genomics-only study?
The distinguishing feature is the expectation of integration. Applications are expected to combine genetic and genomic strategies in a way that makes the overall approach stronger than either method by itself for understanding complex, multi-factorial lung disease traits in humans.
What grant mechanism is used for this funding?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which typically supports hypothesis-driven, investigator-initiated research projects with defined specific aims and a clear research plan.
Does the FOA specify a fixed award amount?
No. The text provided indicates there is no single fixed award size. Budgets are expected to vary based on the scope and resource needs of each proposed project.
Does the FOA specify a fixed project period or duration?
No. The announcement does not set one fixed project period. Project durations are expected to vary depending on what each application proposes.
How many awards will NIH make under this opportunity?
The text provided does not commit to a specific number of awards. The number and size of awards depend on availability of funds and on factors such as scientific quality, feasibility, duration, and cost of the applications that are selected for funding.
Is there a cost sharing or matching requirement?
No. The opportunity explicitly states there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.
What CFDA number is associated with this program?
This opportunity is listed under CFDA 93.838 (Lung Diseases Research).
Which agency administers this grant?
The program is administered by the National Institutes of Health (NIH).
Are there multiple due dates or a single deadline?
Receipt is structured around multiple due dates rather than a single deadline. Applicants are directed to the full announcement for the specific submission schedule and detailed instructions.
Where can applicants find the full FOA text and instructions?
The full announcement is available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-07-135.html.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizational types. Eligible applicants include 501(c)(3) nonprofits (and certain nonprofits without 501(c)(3) status), public and private institutions of higher education, small businesses, and various government entities.
Are state and local government entities eligible?
Yes. Eligible applicants include state governments and local governments, including counties, cities/townships, special district governments, and independent school districts.
Are nonprofit organizations eligible?
Yes. 501(c)(3) nonprofits are eligible, and certain nonprofits without 501(c)(3) status are also eligible.
Are public and private universities eligible?
Yes. Public and private institutions of higher education are listed as eligible applicants.
Are small businesses eligible to apply?
Yes. Small businesses are included among the eligible applicant types.
Are tribal governments or tribal organizations eligible?
Yes. Native American tribal governments (federally recognized) are eligible, and Native American tribal organizations (other than federally recognized tribal governments) are also eligible.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible.
Are faith-based or community-based organizations eligible?
Yes. The announcement notes that faith-based or community-based organizations are eligible to apply.
Are federal government agencies eligible to apply?
Yes. The announcement notes that eligible federal government agencies may apply.
Are foreign institutions eligible to apply as the applicant organization?
No. A key restriction is that foreign institutions are not eligible to apply. The applicant organization must be U.S.-based.
Can a U.S.-based applicant include international collaborations?
The text provided indicates only that foreign institutions cannot be the applicant. It also notes that collaborations with international components may be possible if they fit within NIH policy and the specific rules described in the full announcement.
What kinds of projects are likely to be considered a good fit?
Projects are expected to integrate genetic and genomic approaches to uncover genes linked to complex lung disease traits in human populations. A strong fit would typically explain why integration is necessary and how genetic findings will be strengthened by genomic evidence (or vice versa) to improve understanding of disease mechanisms, risk stratification, or relevant biological pathways for lung health.
What lung conditions or traits does the FOA focus on?
The FOA focuses on complex human lung disease traits in general, emphasizing multi-factorial conditions where many genes and environmental influences may contribute.
What should applicants do if they have trouble accessing or linking to the FOA webpage?
NIH provides a webmaster contact for technical issues accessing or linking to the posting: FBOWebmaster@OD.NIH.GOV.
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