Opportunity Information: Apply for RFA DA 10 003
Apply for RFA DA 10 003
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Integrating Translational Neuroscience and Adolescent Drug Abuse Treatment (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on May 28, 2009 and posted on May 28, 2009.
- Applicants must submit their applications by Sep 1, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Private institutions of higher education Public housing authorities/Indian housing authorities Special district governments County governments City or township governments Independent school districts For profit organizations other than small businesses State governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Integrating Translational Neuroscience and Adolescent Drug Abuse Treatment (R21) funding opportunity (RFA-DA-10-003) is a National Institutes of Health initiative led by the National Institute on Drug Abuse (NIDA) that aims to spark early-stage, collaborative projects connecting developmental neuroscience with real-world adolescent substance use treatment. The central idea is to move beyond treating adolescent drug problems as a smaller version of adult addiction treatment and instead build interventions that reflect what is known about the adolescent brain, including ongoing neurodevelopment, cognitive maturation, decision-making, reward sensitivity, self-control, and learning processes. By encouraging teams to translate findings from brain development, cognition, and neuroscience into treatment innovation, the program is trying to accelerate the creation of more effective, developmentally appropriate approaches for adolescents.
This opportunity uses the NIH R21 mechanism, which is designed for exploratory and developmental work rather than large, definitive clinical trials. In practical terms, the R21 here functions as a planning and pilot phase to help research teams form or strengthen multidisciplinary partnerships and generate the foundation needed for a later, more substantial R01 application. The FOA explicitly supports activities that help investigators prepare a competitive, full-scale translational research program. That can include preliminary studies to test feasibility or refine methods, efforts to harmonize measures across sites, and other early data collection needed to justify a larger project. It also supports collaboration-building activities like scientific workshops, targeted training in specialized research methods, and coordination efforts that enable multi-site or multi-disciplinary translational research focused on adolescent drug abuse treatment.
The scope emphasizes translational research, meaning it is not just basic neuroscience and not just clinical treatment research in isolation. The expectation is that investigative teams will actively integrate knowledge about adolescent neurodevelopment into treatment development or enhancement, with the long-term aim of improving outcomes for adolescents with substance use problems. While the FOA text highlights integration of brain development and cognition into innovative treatment strategies, it also leaves room for different ways of building that bridge, such as incorporating neuroscience-informed targets, using developmentally sensitive outcome measures, or designing interventions that align with adolescent learning and motivation systems. The key is that the work should be oriented toward improving adolescent treatment through a neuroscience-informed, developmentally grounded framework.
Funding for the program was estimated at a total of $1,500,000, with NIDA anticipating approximately 3 to 4 awards. The listed award ceiling is $200,000. There is no cost sharing or matching requirement, which reduces barriers for applicants who may not have non-federal funds available to contribute. The opportunity was posted May 28, 2009, with an original and current closing date of September 1, 2009, and it was archived October 2, 2009.
Eligibility is broad and includes a wide range of organizational types. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (other than small businesses as well as small businesses are both listed among eligible categories), and multiple levels of government such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility details also explicitly include faith-based or community-based organizations, federally recognized tribal governments and other tribal organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, regional organizations, eligible federal agencies, and even non-U.S. entities (foreign organizations), as well as U.S. territories or possessions. This wide eligibility aligns with the FOA's emphasis on building collaborative networks that can unite neuroscience expertise, clinical treatment settings, and community or service systems that work directly with adolescents.
Overall, the grant opportunity is best understood as a catalyst for team formation and early translational groundwork. It is meant to help researchers and treatment-focused partners develop the shared language, methods, and pilot evidence needed to mount larger, more definitive studies that bring modern developmental neuroscience into adolescent substance use treatment design and delivery. For additional official details, the FOA link provided is http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-10-003.html, and NIH lists the Office of Extramural Research webmaster contacts for access or technical issues.
Frequently Asked Questions (FAQs)
What is the Integrating Translational Neuroscience and Adolescent Drug Abuse Treatment (R21) opportunity?
It is a National Institutes of Health (NIH) funding opportunity (RFA-DA-10-003) led by the National Institute on Drug Abuse (NIDA). The program is intended to spark early-stage, collaborative projects that connect developmental neuroscience with real-world adolescent substance use treatment, with the goal of creating more developmentally appropriate and effective interventions for adolescents.
What is the main purpose of this funding opportunity?
The main purpose is to accelerate treatment innovation for adolescents by integrating what is known about adolescent brain development and cognition into the design or improvement of adolescent drug abuse treatment. The program encourages research teams to translate insights about neurodevelopment, cognitive maturation, decision-making, reward sensitivity, self-control, and learning processes into practical treatment approaches.
Which NIH institute is leading this initiative?
The initiative is led by the National Institute on Drug Abuse (NIDA), which is part of the NIH.
What does "translational" mean in the context of this FOA?
In this FOA, "translational" means the work should actively bridge developmental neuroscience (including brain development and cognition) and adolescent substance use treatment. Projects are expected to go beyond basic neuroscience alone or clinical treatment research alone, and instead integrate both in a way that is oriented toward improving adolescent treatment outcomes.
Why does the FOA emphasize adolescent-specific approaches rather than adapting adult addiction treatment?
The FOA is built on the idea that adolescent drug problems should not be treated as a smaller version of adult addiction. It emphasizes designing interventions that reflect adolescent neurodevelopment and developmental differences, including ongoing brain maturation and differences in learning, motivation, reward sensitivity, and self-control.
What funding mechanism does this opportunity use?
This opportunity uses the NIH R21 mechanism, which is designed for exploratory and developmental research rather than large, definitive clinical trials.
What is the intended role of the R21 for this program?
Here, the R21 functions as a planning and pilot phase. It is meant to help teams form or strengthen multidisciplinary partnerships and generate early evidence, feasibility data, or methodological foundations needed to pursue a later, larger-scale R01 translational research program.
Does this R21 support large, definitive clinical trials?
The information provided describes the R21 as exploratory and developmental rather than intended for large, definitive clinical trials. The emphasis is on early-stage groundwork, pilots, and preparation for a later, more substantial application (such as an R01).
What kinds of activities are explicitly supported under this FOA?
The FOA explicitly supports activities that help investigators prepare a competitive, full-scale translational research program. Examples mentioned include preliminary studies to test feasibility or refine methods, efforts to harmonize measures across sites, early data collection needed to justify a larger project, and collaboration-building activities such as scientific workshops, targeted training in specialized research methods, and coordination efforts that enable multi-site or multi-disciplinary translational research focused on adolescent drug abuse treatment.
What does "integrating developmental neuroscience into treatment" look like in practice?
Based on the description provided, integration could include incorporating neuroscience-informed targets into interventions, using developmentally sensitive outcome measures, or designing treatment strategies that align with adolescent learning and motivation systems. The common requirement is that the work should be oriented toward improving adolescent treatment using a neuroscience-informed, developmentally grounded framework.
Is the FOA limited to one specific way of connecting neuroscience and treatment?
No. While the FOA highlights integrating brain development and cognition into innovative treatment strategies, it also leaves room for different ways of building the bridge between neuroscience and clinical treatment, as long as the work remains translational and focused on improving adolescent treatment through a developmentally grounded approach.
How much total funding was estimated for this program?
Total program funding was estimated at $1,500,000.
How many awards did NIDA anticipate making?
NIDA anticipated approximately 3 to 4 awards.
What is the award ceiling for this opportunity?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad. The information provided lists eligible applicants across many organizational types, including public and private institutions of higher education; nonprofits (including 501(c)(3) and non-501(c)(3)); for-profit organizations; small businesses; and multiple levels of government such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are community-based or faith-based organizations eligible?
Yes. The eligibility details explicitly include faith-based or community-based organizations.
Are tribal organizations eligible?
Yes. Eligibility explicitly includes federally recognized tribal governments and other tribal organizations.
Are minority-serving institutions eligible (HBCUs, Hispanic-serving institutions, TCCUs, and others)?
Yes. The eligibility details explicitly include Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian serving institutions.
Are foreign organizations or non-U.S. entities eligible to apply?
Yes. The eligibility information explicitly includes non-U.S. entities (foreign organizations).
Are U.S. territories or possessions included in eligibility?
Yes. The eligibility details include U.S. territories or possessions.
Does this FOA encourage collaborative and multidisciplinary teams?
Yes. A major theme of the opportunity is to form or strengthen multidisciplinary partnerships that can connect neuroscience expertise with clinical treatment settings and community or service systems working directly with adolescents.
What is the key outcome this program is ultimately trying to improve?
The long-term aim described is to improve outcomes for adolescents with substance use problems by developing or enhancing treatment approaches that are neuroscience-informed and developmentally appropriate.
When was this funding opportunity posted and when did it close?
The opportunity was posted on May 28, 2009. The original and current closing date listed is September 1, 2009.
What does it mean that the opportunity is "archived"?
The listing indicates it was archived on October 2, 2009, which signals the opportunity is no longer open under that posting.
Where can applicants find the official FOA text and details?
The FOA link provided is http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-10-003.html.
Who should be contacted for access or technical issues related to NIH extramural information?
The information provided notes that NIH lists Office of Extramural Research webmaster contacts for access or technical issues.
What is the overall "best fit" summary of this opportunity?
Based on the description, this FOA is best understood as a catalyst for early translational groundwork and team formation. It supports pilot and planning activities that help partners build shared methods and preliminary evidence to support a later, more definitive translational research effort that brings modern developmental neuroscience into adolescent substance use treatment design and delivery.
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