Opportunity Information: Apply for PA 07 445
Apply for PA 07 445
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Interdisciplinary Research on Implantation (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Sep 5, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: City or township governments State governments Special district governments Native American tribal governments (Federally recognized) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Public housing authorities/Indian housing authorities Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education.
- Foreign institutions are eligible to apply.
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Opportunity Summary:
The Interdisciplinary Research on Implantation (R01) opportunity (Funding Opportunity Number PA 07 445) is a National Institutes of Health (NIH) discretionary grant program designed to push forward research on the biological mechanisms that govern blastocyst implantation. The central goal is to encourage truly interdisciplinary projects that can tackle implantation as a complex, multi-system process, with a particular emphasis on immunological approaches. In practice, this means the FOA is looking for studies that can explain how immune cells, inflammatory signals, maternal-fetal immune tolerance, and related pathways influence whether implantation succeeds or fails. The broader public health driver behind this program is infertility, especially infertility linked to implantation failure, where better mechanistic understanding could eventually inform improved diagnostics and therapies.
A key feature of the announcement is its strong encouragement of multiple principal investigators (PDs/PIs), ideally representing different scientific disciplines. NIH highlights that human implantation is difficult to study directly and that existing model systems are limited, so the FOA is deliberately structured to bring together complementary expertise. Applicants are expected to propose independent R01 research projects, meaning each award supports a distinct research plan rather than a subproject within a larger center grant. At the same time, NIH anticipates and supports cross-project collaboration: funded teams are expected to participate in semiannual Collaborative Meetings intended to promote data sharing, coordination, and the formation of larger scientific collaborations. The idea is that even though projects are independently funded, the program as a whole functions like a coordinated network where results can be compared, integrated, and leveraged to accelerate progress.
The mechanism of support is the NIH Research Project Grant (R01), which is the standard NIH award for investigator-initiated biomedical research. The activity category is Health, and the CFDA listing is 93.865 (Child Health and Human Development Extramural Research), reflecting the programmatic alignment with reproductive and developmental health priorities. The announcement does not require cost sharing or matching funds, which lowers the financial barrier for many applicants and keeps the focus on scientific merit and feasibility.
Eligibility is broad and includes a wide range of domestic U.S. organizations and government entities, such as state, county, city/township, and special district governments; federally recognized tribal governments and other tribal organizations; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; public housing authorities/Indian housing authorities; nonprofit organizations (including both those with and without 501(c)(3) status, other than institutions of higher education); for-profit organizations (including small businesses and other for-profits); and additional applicants as described in the full announcement. Importantly, foreign institutions are eligible to apply, which signals NIH interest in attracting the best science globally and acknowledges that implantation research capacity and relevant cohorts, methods, or expertise may be distributed internationally.
From an administrative perspective, the FOA was posted on September 5, 2007, with multiple receipt dates (rather than a single deadline), and it was later archived on August 5, 2010. The full text of the announcement was provided through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-07-445.html, and NIH’s Office of Extramural Research (OER) listed webmaster contacts for applicants who have trouble accessing the online materials. Overall, this opportunity is best understood as an NIH R01 program aimed at building a collaborative, interdisciplinary research community focused on the immunology and broader biology of implantation, with the long-term aim of generating insights that can reduce infertility caused by implantation failure.
Frequently Asked Questions (FAQs): Interdisciplinary Research on Implantation (R01) - PA-07-445
What is this funding opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity titled "Interdisciplinary Research on Implantation (R01)." It uses the NIH Research Project Grant (R01) mechanism and is intended to advance research on the biological mechanisms that govern blastocyst implantation.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-07-445.
What research area is NIH trying to advance through this FOA?
The FOA aims to push forward research on the biological mechanisms that control blastocyst implantation, especially by treating implantation as a complex, multi-system process that benefits from interdisciplinary approaches.
Is there a particular scientific emphasis within implantation research?
Yes. The FOA places particular emphasis on immunological approaches, including how immune cells, inflammatory signals, maternal-fetal immune tolerance, and related pathways influence whether implantation succeeds or fails.
What public health problem is this opportunity ultimately trying to address?
The broader public health driver is infertility, particularly infertility linked to implantation failure. NIH is supporting mechanistic research that could eventually inform improved diagnostics and therapies.
What grant mechanism does this program use?
The program uses the NIH Research Project Grant (R01) mechanism, NIH's standard award for investigator-initiated biomedical research.
Are applicants expected to propose independent projects or subprojects within a larger program?
Applicants are expected to propose independent R01 research projects. Each award supports a distinct research plan rather than functioning as a subproject within a larger center-type grant.
Does NIH encourage interdisciplinary teams or multiple principal investigators?
Yes. A key feature is strong encouragement of multiple principal investigators (PDs/PIs), ideally from different scientific disciplines, to better address implantation as a complex problem.
Why is an interdisciplinary approach highlighted as important for this topic?
NIH highlights that human implantation is difficult to study directly and that existing model systems are limited. The FOA is structured to bring together complementary expertise to overcome these constraints.
Even if projects are independently funded, is collaboration expected after awards are made?
Yes. NIH anticipates and supports cross-project collaboration. Funded teams are expected to participate in semiannual Collaborative Meetings aimed at promoting data sharing, coordination, and broader collaboration.
How often are the program's Collaborative Meetings expected to occur?
The FOA anticipates semiannual Collaborative Meetings (twice per year).
How does NIH describe the overall structure of the program once multiple awards are made?
Although projects are independently funded as R01s, the program is intended to function like a coordinated network where results can be compared, integrated, and used to accelerate progress.
Is cost sharing or matching required?
No. The announcement does not require cost sharing or matching funds.
What is the activity category for this opportunity?
The activity category is Health.
What is the CFDA listing associated with this opportunity?
The CFDA listing is 93.865, described as Child Health and Human Development Extramural Research.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes many domestic U.S. organizations and government entities, such as state governments, county governments, city/township governments, special district governments, federally recognized tribal governments, other tribal organizations, public and state-controlled institutions of higher education, private institutions of higher education, independent school districts, public housing authorities/Indian housing authorities, nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education), and for-profit organizations (including small businesses and other for-profits), plus additional applicants as described in the full announcement.
Are foreign institutions eligible to apply?
Yes. Foreign institutions are eligible to apply.
When was the FOA posted?
The FOA was posted on September 5, 2007.
Does the FOA have one deadline or multiple receipt dates?
The FOA had multiple receipt dates rather than a single deadline.
What does it mean that the FOA was archived?
The FOA was later archived on August 5, 2010, indicating the announcement is no longer active as a current solicitation.
Where can the full announcement text be found?
The full text was provided through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-07-445.html
What should someone do if they cannot access the online FOA materials?
NIH's Office of Extramural Research (OER) listed webmaster contacts for applicants who have trouble accessing the online materials.
What is the main takeaway for potential applicants reviewing this opportunity?
This is best understood as an NIH R01 program designed to build a collaborative, interdisciplinary research community focused on the immunology and broader biology of implantation, with the long-term aim of generating insights that can reduce infertility caused by implantation failure.
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