Opportunity Information: Apply for RFA AG 15 010
Apply for RFA AG 15 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Interdisciplinary Research to Understand the Vascular Contributions to Alzheimers Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.866 Aging Research.
- This funding opportunity was created on Aug 25, 2014 and posted on Aug 25, 2014.
- Applicants must submit their applications by Feb 3, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: City or township governments Independent school districts Native American tribal governments (Federally recognized) Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Special district governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity announcement RFA-AG-15-010, titled "Interdisciplinary Research to Understand the Vascular Contributions to Alzheimers Disease (R01)," was a discretionary grant program designed to push forward research on how vascular biology and vascular disease processes influence the development and progression of Alzheimers disease. The central aim was to encourage interdisciplinary projects that bring together expertise across fields such as neuroscience, aging biology, vascular medicine, epidemiology, imaging, bioengineering, and related areas, with the expectation that combining perspectives and methods would clarify the mechanisms linking vascular factors to Alzheimers complex etiology. In practical terms, the opportunity targeted studies that move beyond viewing Alzheimers as purely neurodegenerative, instead treating cerebrovascular dysfunction and systemic vascular risk as important contributors that may interact with classic Alzheimers pathology.
This announcement used the NIH R01 mechanism, meaning it supported hypothesis-driven, investigator-initiated research projects of substantial scope. While the full scientific priorities are detailed in the official FOA link, the provided description makes clear that NIH was seeking mechanistic understanding rather than only descriptive associations. That typically includes work that can explain how changes in blood vessels, blood flow regulation, blood-brain barrier integrity, small vessel disease, endothelial dysfunction, inflammation tied to vascular injury, or impaired clearance pathways could contribute to neuronal injury and cognitive decline, and how those processes might intersect with known Alzheimers-related changes. The emphasis on interdisciplinary research suggests NIH expected applications to integrate multiple approaches (for example, combining human studies with animal or cellular models, pairing imaging with biomarkers, or linking clinical vascular phenotyping with neuropathology and cognitive outcomes) to get at causal pathways and not just correlations.
From an administrative and budget standpoint, NIH estimated a total of $4,000,000 in funding under this announcement, with an award ceiling of $750,000. There was no cost sharing or matching requirement, which aligns with standard NIH practice for most research grants. The opportunity was posted and created on August 25, 2014, with an application closing date of February 3, 2015. It was archived on March 6, 2015, meaning it is no longer accepting applications, but it remains useful as a reference for the kinds of vascular-Alzheimers research themes NIH has prioritized.
Eligibility was broad and intentionally inclusive. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and other nonprofit structures), for-profit organizations (other than small businesses, though small businesses were also eligible), and many levels of government entities (state, county, city or township, special district governments, and certain housing authorities). The eligibility list also included tribal governments and tribal organizations, independent school districts, and a range of mission-driven institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs). Notably, non-U.S. entities were eligible to apply, including foreign organizations and foreign institutions, and foreign components (as defined under the NIH Grants Policy Statement) were allowed. U.S. territories or possessions and regional organizations were also listed, along with eligible federal agencies and faith-based or community-based organizations, reflecting NIHs interest in attracting the best science from a wide range of organizational settings.
The activity categories and CFDA numbers indicate the program sat within NIHs health research portfolio, specifically touching both neuroscience/neurological disorders (93.853) and aging research (93.866). That positioning reinforces the program intent: vascular contributions to Alzheimers disease are relevant both to brain disorders research and to broader aging-related mechanisms and risk factors. For applicants at the time, the key takeaway would have been to craft proposals that clearly articulate vascular mechanisms, explain how multiple disciplines will be integrated in a cohesive research plan, and demonstrate how the work could resolve uncertainties about how vascular factors contribute to Alzheimers onset, progression, or heterogeneity across patients.
For reference and full details, NIH provided the official announcement link at http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-010.html, and directed technical or access issues to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the funding opportunity RFA-AG-15-010?
RFA-AG-15-010 is a National Institutes of Health (NIH) funding opportunity announcement titled "Interdisciplinary Research to Understand the Vascular Contributions to Alzheimers Disease (R01)." It was a discretionary grant program focused on advancing research into how vascular biology and vascular disease processes influence the development and progression of Alzheimers disease.
What was the main goal of this NIH announcement?
The central goal was to encourage interdisciplinary, mechanism-focused research that clarifies how vascular factors contribute to Alzheimers disease. The program aimed to move beyond treating Alzheimers as purely neurodegenerative by emphasizing cerebrovascular dysfunction and systemic vascular risk as contributors that may interact with classic Alzheimers pathology.
What type of grant mechanism did this opportunity use?
This announcement used the NIH R01 mechanism, which supports hypothesis-driven, investigator-initiated research projects of substantial scope.
What kinds of research approaches was NIH looking for?
Based on the description provided, NIH emphasized mechanistic understanding rather than purely descriptive associations. The opportunity encouraged projects that integrate multiple disciplines and methods, for example combining human studies with animal or cellular models, pairing imaging with biomarkers, or linking clinical vascular phenotyping with neuropathology and cognitive outcomes, with the intent of clarifying causal pathways rather than only correlations.
What scientific themes were highlighted as relevant to vascular contributions to Alzheimers disease?
The description points to studies that can explain how vascular-related changes could contribute to neuronal injury and cognitive decline and intersect with Alzheimers-related changes. Examples mentioned include blood vessel changes, blood flow regulation, blood-brain barrier integrity, small vessel disease, endothelial dysfunction, inflammation tied to vascular injury, and impaired clearance pathways.
Why did NIH emphasize "interdisciplinary" research for this topic?
The announcement aimed to bring together expertise across fields such as neuroscience, aging biology, vascular medicine, epidemiology, imaging, bioengineering, and related areas. The expectation was that integrating perspectives and methods would better resolve complex mechanisms linking vascular factors to Alzheimers disease etiology and progression.
How much total funding was NIH expecting to provide under this announcement?
NIH estimated a total of $4,000,000 in funding under this announcement.
Was there an award ceiling for individual grants?
Yes. The award ceiling listed for this opportunity was $750,000.
Was cost sharing or matching required?
No. The announcement indicated there was no cost sharing or matching requirement.
When was the opportunity posted and when did it close?
It was posted and created on August 25, 2014. The application closing date was February 3, 2015.
Is this funding opportunity still accepting applications?
No. It was archived on March 6, 2015, which means it is no longer accepting applications.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education; nonprofits (including 501(c)(3) and other nonprofit structures); for-profit organizations (including small businesses, which were also eligible); and many government entities such as state, county, city or township, special district governments, and certain housing authorities. The list also included tribal governments and tribal organizations, independent school districts, U.S. territories or possessions, regional organizations, eligible federal agencies, and faith-based or community-based organizations.
Were minority-serving institutions included in the eligible applicant types?
Yes. Eligible institution types explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs).
Could non-U.S. organizations apply?
Yes. Non-U.S. entities were eligible to apply, including foreign organizations and foreign institutions. Foreign components (as defined under the NIH Grants Policy Statement) were also allowed.
What CFDA numbers were associated with this program?
The opportunity referenced CFDA numbers 93.853 and 93.866, indicating alignment with NIH portfolios related to neuroscience/neurological disorders and aging research.
Where can I find the official FOA details?
The official announcement link provided was http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-010.html.
Who should be contacted for technical or access issues with the announcement?
NIH directed technical or access issues to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What was the practical proposal takeaway for applicants at the time?
Applicants would have needed to clearly articulate vascular mechanisms, explain how multiple disciplines would be integrated into a cohesive research plan, and demonstrate how the project could resolve uncertainties about how vascular factors contribute to Alzheimers onset, progression, or differences across patients.
What does it mean that this was a discretionary grant program?
Based on the description provided, it indicates NIH used this announcement to strategically push research forward in a specific priority area: understanding vascular contributions to Alzheimers disease through interdisciplinary, mechanism-oriented R01 projects.
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