Opportunity Information: Apply for RFA AI 09 010

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "International Collaborations in Infectious Disease Research (ICIDR) (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.856 Microbiology and Infectious Diseases Research.
  • This funding opportunity was created on Mar 20, 2009 and posted on Mar 6, 2009.
  • Applicants must submit their applications by Jul 23, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $6,300,000.00 to eligible and selected applicants.
  • Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public and State controlled institutions of higher education For profit organizations other than small businesses Small businesses County governments Special district governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Faith based or Community based Organizations Regional Organizations.
Apply for RFA AI 09 010

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Opportunity Summary:

The International Collaborations in Infectious Disease Research (ICIDR) (U01) funding opportunity (RFA-AI-09-010) is an NIH program led by the National Institute of Allergy and Infectious Diseases (NIAID) designed to support U.S.-based institutions that want to carry out collaborative infectious disease research with foreign (non-U.S.) investigators and organizations. The central idea is to fund research partnerships focused on infectious diseases that have major public health impact in resource-constrained countries. Beyond generating scientific findings, the program is explicitly geared toward strengthening long-term international research relationships, expanding hands-on research experience for both U.S. and overseas investigators, and building or enhancing research capacity in the settings where the diseases are most burdensome.

This opportunity uses the U01 cooperative agreement mechanism, which typically means the NIH expects to have more substantial scientific or programmatic involvement than in a standard research project grant. In practice, applicants should be prepared for an award structure where the funded team leads the science day to day, but NIH staff may participate through cooperative agreement terms such as collaboration on milestones, coordination, or other shared responsibilities aimed at keeping the project aligned with the FOA goals. The overall intent is to support well-managed, genuinely joint projects rather than loosely connected parallel studies.

NIAID anticipated approximately $6.3 million in total costs to be awarded under this FOA, supporting an estimated 5 to 9 awards, including both new awards and competing renewals. The project period could be up to five years. The budget guidance set a direct cost cap of $500,000 for year 1, with future years recommended to rise only by up to a 3 percent escalation, signaling an expectation of realistic, tightly justified budgets that do not expand rapidly over time.

Eligibility is broad and includes many organizational types, reflecting an intent to attract capable applicants across academia, government, and the nonprofit and private sectors. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), and governmental entities such as state, county, city/township, and special district governments. The listing also notes additional eligible applicants such as faith-based or community-based organizations and regional organizations, indicating that NIAID was open to a range of institutional models as long as the applicant could successfully manage a complex international research collaboration.

For leadership, the FOA allows flexibility: any individual(s) with appropriate expertise, capability, and institutional support may serve as Project Director/Principal Investigator (PD/PI). Multiple PDs/PIs are explicitly permitted, which fits the collaboration-focused nature of the program and can help formalize shared leadership between disciplines, institutions, or partnering teams. The announcement also reiterates NIH’s standing encouragement for applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities. Applicants may submit more than one application as long as each submission is scientifically distinct, allowing institutions with multiple strong international collaborations to propose separate projects rather than forcing a single consolidated application.

Administratively, this was a discretionary funding opportunity under the cooperative agreement instrument type, aligned with the Health funding activity category and associated with CFDA 93.856 (Microbiology and Infectious Diseases Research). There was no cost sharing or matching requirement. Key dates included a posted date of March 6, 2009, with an original and current closing date of July 23, 2009, and an archive date of August 23, 2009. The full announcement was available through the NIH grants guide link provided in the notice, with technical access support routed through the NIH Office of Extramural Research webmaster contact.

Frequently Asked Questions (FAQs): International Collaborations in Infectious Disease Research (ICIDR) (U01) - RFA-AI-09-010

What is the ICIDR (U01) funding opportunity (RFA-AI-09-010)?

The International Collaborations in Infectious Disease Research (ICIDR) (U01) opportunity (RFA-AI-09-010) is an NIH program led by the National Institute of Allergy and Infectious Diseases (NIAID). It is designed to support U.S.-based institutions that want to conduct collaborative infectious disease research with foreign (non-U.S.) investigators and organizations.

What is the main goal of this program?

The program aims to fund research partnerships focused on infectious diseases with major public health impact in resource-constrained countries. It also aims to strengthen long-term international research relationships, expand hands-on research experience for U.S. and overseas investigators, and build or enhance research capacity in locations where disease burden is highest.

What type of grant mechanism is used?

This opportunity uses the U01 cooperative agreement mechanism.

What does a U01 cooperative agreement imply for NIH involvement?

A U01 cooperative agreement typically involves more substantial NIH scientific or programmatic involvement than a standard research project grant. Funded teams generally lead the science day to day, while NIH staff may participate through cooperative agreement terms such as collaboration on milestones, coordination activities, or shared responsibilities intended to keep the project aligned with the funding opportunity's goals.

What kinds of projects does NIAID appear to be seeking under this FOA?

The program intent emphasizes well-managed, genuinely joint international collaborations rather than loosely connected parallel studies. Projects should align with the goal of impactful infectious disease research in resource-constrained settings while also supporting long-term partnerships and capacity building.

Who is this program intended to support?

The program is intended to support U.S.-based institutions that will carry out collaborative infectious disease research with foreign (non-U.S.) investigators and organizations.

Does the program specifically focus on certain settings or countries?

Based on the description provided, the focus is on resource-constrained countries and settings where infectious diseases impose a major public health burden.

How much funding was anticipated under this FOA?

NIAID anticipated approximately $6.3 million in total costs to be awarded under this FOA.

How many awards were expected to be made?

An estimated 5 to 9 awards were anticipated, including both new awards and competing renewals.

What is the maximum project period?

The project period could be up to five years.

What is the budget cap for Year 1?

The budget guidance set a direct cost cap of $500,000 for Year 1.

How should budgets change in future years?

Future years were recommended to rise only by up to a 3 percent escalation, indicating an expectation of realistic, tightly justified budgets that do not expand rapidly over time.

Is cost sharing or matching required?

No. There was no cost sharing or matching requirement.

What types of organizations are eligible to apply?

Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), and governmental entities such as state, county, city/township, and special district governments.

Are faith-based or community-based organizations eligible?

Yes. The listing notes additional eligible applicants such as faith-based or community-based organizations.

Are regional organizations eligible?

Yes. Regional organizations are noted among additional eligible applicant types.

Who can serve as the Project Director/Principal Investigator (PD/PI)?

Any individual(s) with appropriate expertise, capability, and institutional support may serve as PD/PI.

Are multiple PDs/PIs allowed?

Yes. Multiple PDs/PIs are explicitly permitted, consistent with the collaboration-focused nature of the program.

Does NIH encourage applications from specific groups of investigators?

Yes. The announcement reiterates NIH's standing encouragement for applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities.

Can an institution submit more than one application?

Yes. Applicants may submit more than one application as long as each submission is scientifically distinct.

What is the funding instrument type and general classification of this opportunity?

This was described as a discretionary funding opportunity under the cooperative agreement instrument type, aligned with the Health funding activity category.

What CFDA number is associated with this opportunity?

This opportunity is associated with CFDA 93.856 (Microbiology and Infectious Diseases Research).

When was the opportunity posted?

The posted date was March 6, 2009.

What was the closing date for applications?

The original and current closing date listed was July 23, 2009.

When was the opportunity archived?

The archive date was August 23, 2009.

Where could applicants find the full announcement?

The full announcement was available through the NIH grants guide link provided in the notice.

Where was technical access support directed?

Technical access support was routed through the NIH Office of Extramural Research webmaster contact.

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