Opportunity Information: Apply for RFA AI 14 001
Apply for RFA AI 14 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "International Collaborations in Infectious Diseases Research (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Nov 27, 2013 and posted on Nov 27, 2013.
- Applicants must submit their applications by Mar 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) County governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Small businesses Special district governments City or township governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled International Collaborations in Infectious Diseases Research (U01) (Funding Opportunity Number RFA-AI-14-001) is a National Institutes of Health (NIH) funding announcement designed to support joint infectious disease research projects that connect U.S. institutions with partners in resource-constrained countries. The central goal is to generate new scientific knowledge about infectious diseases of major public health importance in low- and middle-income settings, while also strengthening long-term international research relationships and building capacity where the burden of disease is often highest. A key boundary of the program is that it supports infectious disease research excluding HIV/AIDS, so proposed projects must focus on other pathogens or syndromes with significant public health impact.
This opportunity uses the Cooperative Agreement mechanism (U01), which generally means awardees should expect a more active partnership with NIH staff compared with standard investigator-initiated grants. In practice, that typically involves coordination, shared expectations around milestones or deliverables, and ongoing programmatic involvement to help ensure the collaboration stays aligned with the goals of the announcement. The work is intended to benefit both sides of the partnership: expanding research experience and opportunities for U.S. and foreign investigators, increasing the evidence base needed to address real-world public health problems, and fostering sustainable research capacity and infrastructure in the collaborating countries.
A defining requirement is the international collaboration structure. Each application must include, at minimum, one U.S. institution and one eligible foreign (non-U.S.) institution. Foreign eligibility is tied to the World Bank country income classifications, and eligible partners must be located in countries categorized as low-income, lower-middle-income, or upper-middle-income economies. The emphasis on resource-constrained environments indicates that studies should be grounded in the needs, realities, and public health priorities of the partner country context, rather than being purely laboratory-based questions disconnected from local disease burdens and implementation constraints.
The announcement is broadly inclusive regarding who can apply, spanning many organization types across academia, government, nonprofit, and for-profit sectors. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, small businesses, for-profit organizations (other than small businesses), city or township governments, county governments, state governments, independent school districts, special district governments, public housing authorities/Indian housing authorities, and Native American tribal organizations (including federally recognized tribal governments and other tribal organizations). The FOA also explicitly includes a wide range of mission-driven and underserved-community-serving institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations. Importantly, non-U.S. entities are eligible to apply, and foreign components of U.S. organizations are allowed, consistent with NIH policy.
From a funding standpoint, the opportunity is categorized as discretionary and sits within NIH health research activities, with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). The FOA listed an estimated total funding level of $5,000,000 and an award ceiling of $500,000, with no cost-sharing or matching requirement. The original posted date was November 27, 2013, with an application closing date of March 7, 2014, and an archive date of April 7, 2014. While those dates indicate this particular FOA cycle is historical, the structure and intent are still useful as a model for how NIH frames international collaborative infectious disease research programs and what it expects in terms of partnership, capacity building, and public health relevance.
Overall, this grant opportunity is aimed at well-structured, genuinely joint U.S.-international projects that tackle pressing non-HIV infectious disease challenges in eligible low- and middle-income countries, while also leaving behind stronger local research capability and durable collaborative ties. The full announcement was available through NIH at the link provided in the source, and general access issues were routed to the NIH Office of Extramural Research (OER) webmaster contact listed in the opportunity materials.
Frequently Asked Questions (FAQs): International Collaborations in Infectious Diseases Research (U01) - RFA-AI-14-001
1) What is the purpose of the International Collaborations in Infectious Diseases Research (U01) opportunity?
This NIH funding opportunity is designed to support joint infectious disease research projects that connect U.S. institutions with partners in resource-constrained countries. The goal is to generate new scientific knowledge about infectious diseases that are major public health problems in low- and middle-income settings, while also strengthening long-term international research relationships and building local research capacity where disease burden is often highest.
2) What types of diseases or topics are in scope?
The opportunity supports infectious disease research of major public health importance in low- and middle-income settings, with an important limitation: it excludes HIV/AIDS. Projects must focus on other pathogens, conditions, or infectious disease syndromes with significant public health impact.
3) Is HIV/AIDS research allowed under this funding announcement?
No. The program specifically supports infectious disease research excluding HIV/AIDS. Proposals must focus on non-HIV infectious diseases.
4) What does the U01 Cooperative Agreement mechanism mean for applicants?
The U01 is a Cooperative Agreement mechanism. Compared with standard investigator-initiated grants, awardees should generally expect a more active partnership with NIH staff. This typically involves coordination, shared expectations around milestones or deliverables, and ongoing programmatic involvement to help keep the collaboration aligned with the goals of the announcement.
5) What kind of collaboration is required for eligibility?
Each application must include, at minimum, one U.S. institution and one eligible foreign (non-U.S.) institution. The structure is intended to support genuinely joint projects rather than loosely connected efforts.
6) Which foreign countries are eligible for the non-U.S. partner institution?
Foreign eligibility is tied to World Bank country income classifications. The foreign institution must be located in a country categorized as a low-income, lower-middle-income, or upper-middle-income economy.
7) What does "resource-constrained" imply about the expected research setting?
The emphasis on resource-constrained environments indicates projects should be grounded in the needs and public health realities of the partner country context. Studies should reflect local disease burdens, public health priorities, and real-world implementation constraints, rather than being disconnected from local conditions.
8) Who can apply for this NIH funding opportunity?
The announcement is broadly inclusive. Eligible applicants include many organization types across academia, government, nonprofit, and for-profit sectors, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, other for-profit organizations, and multiple types of local and state government entities.
9) Are non-U.S. entities eligible to apply?
Yes. Non-U.S. entities are eligible to apply, consistent with NIH policy. In addition, foreign components of U.S. organizations are allowed.
10) Are community-based and faith-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations among eligible applicants.
11) Are minority-serving institutions specifically included as eligible applicants?
Yes. The FOA explicitly includes institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), and Tribally Controlled Colleges and Universities (TCCUs), among others.
12) What are the expected benefits of the collaboration for U.S. and international partners?
The work is intended to benefit both sides of the partnership. It aims to expand research experience and opportunities for U.S. and foreign investigators, increase the evidence base needed to address real-world public health problems, and foster sustainable research capacity and infrastructure in the collaborating countries.
13) Does the opportunity emphasize capacity building in partner countries?
Yes. A central theme is strengthening long-term international research relationships and building capacity in settings where the burden of infectious disease is often highest. The overall intent includes leaving behind stronger local research capability and durable collaborative ties.
14) What is the estimated total funding level for this opportunity?
The FOA listed an estimated total funding level of $5,000,000.
15) What is the award ceiling for individual awards?
The FOA listed an award ceiling of $500,000.
16) Is cost sharing or matching required?
No. The opportunity indicated there is no cost-sharing or matching requirement.
17) What NIH program area does this opportunity fall under?
It is categorized within NIH health research activities and relates to Allergy and Infectious Diseases Research and Microbiology and Infectious Diseases Research.
18) What CFDA numbers are associated with this funding opportunity?
The CFDA numbers listed are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
19) What are the key dates for this FOA cycle?
The original posted date was November 27, 2013. The application closing date was March 7, 2014. The archive date was April 7, 2014.
20) Is this funding opportunity still open?
Based on the dates provided, this particular FOA cycle is historical (it has an archive date of April 7, 2014). The description remains useful as a model for how NIH structures international collaborative infectious disease research programs and what it expects regarding partnership, capacity building, and public health relevance.
21) Where was the full funding announcement available?
The full announcement was available through NIH at the link provided in the source materials for the opportunity.
22) Who should be contacted for general access issues related to the announcement materials?
General access issues were routed to the NIH Office of Extramural Research (OER) webmaster contact listed in the opportunity materials.
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