Opportunity Information: Apply for RFA DP 11 005
Apply for RFA DP 11 005
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Johnston County Osteoarthritis Project (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.283 Centers for Disease Control and PreventionInvestigations and Technical Assistance.
- This funding opportunity was created on Dec 2, 2010 and posted on Dec 2, 2010.
- Applicants must submit their applications by Mar 4, 2011 On time submission requires that applications be successfully submitted to Grants.gov and validated no later than 500 p.m. eastern time on the deadline date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,250,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Eligibility for this award is limited to the University of North Carolina at Chapel Hill. They are the only institution who has the ability to continue to follow this 20 year cohort and to leverage other federal and private resources to create a rich data set and a variety of analyses to further public health.
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Opportunity Summary:
The Johnston County Osteoarthritis Project (U01) grant opportunity (Funding Opportunity Number RFA DP 11 005) was a Centers for Disease Control and Prevention (CDC) discretionary funding announcement supporting a long-running, population-based, longitudinal public health study focused on osteoarthritis (OA). The project’s core purpose was to continue and strengthen a community cohort in Johnston County, North Carolina, to better understand how hip and knee OA develops over time, how often it occurs in the population, what factors increase or decrease risk, and how the disease progresses once it appears. By maintaining a consistent cohort and repeatedly measuring outcomes over many years, the study was positioned to produce more reliable evidence than short-term or clinic-based studies, especially for a chronic condition like OA where onset and progression can unfold slowly.
The research aims emphasized two main areas. First, the project was intended to estimate and track the prevalence (how many people have OA at a given time) and incidence (how many new cases arise over time) of hip and knee OA, while also identifying risk factors tied to both the occurrence and the progression of disease. These risk factors can include demographic characteristics, body weight and physical activity patterns, history of joint injury, occupational or biomechanical stresses, comorbid health conditions, and other exposures that may influence joint health across the lifespan. Second, the announcement highlighted the importance of examining racial or ethnic differences in OA outcomes and in how risk factors affect those outcomes. In practical terms, that means the study was expected to evaluate whether disease burden, symptoms, functional impacts, progression patterns, and the influence of specific risk factors differ across racial or ethnic groups, which is central to understanding and addressing health disparities.
The mechanism for funding was a cooperative agreement (U01), which typically indicates substantial federal scientific or programmatic involvement during the project period compared with a standard grant. The funding activity category was Health, and the CFDA listing was 93.283 (CDC Investigations and Technical Assistance). The CDC anticipated making a single award, with an estimated total funding level of $3,250,000 and an award ceiling of $750,000. There was no cost-sharing or matching requirement.
Eligibility was explicitly limited to the University of North Carolina at Chapel Hill. The rationale provided was that UNC Chapel Hill was the only institution positioned to continue following the established 20-year cohort and to leverage existing federal and private resources connected to the study. This limitation reflects the value of continuity in long-term cohort research: keeping the same participant base, measurement protocols, and historical data infrastructure is often essential for valid trend analyses and for preserving the scientific value of decades of follow-up.
Key administrative dates show the announcement was posted on December 2, 2010, with an application deadline of March 4, 2011, requiring submission through Grants.gov and validation by 5:00 p.m. Eastern Time on the due date. The opportunity was archived on April 3, 2011. For access issues related to the full announcement, applicants were directed to CDC’s Procurement and Grants Office, Technical Information and Management Section (TIMS), with a phone contact (770-488-2700) and a general email field noted in the notice.
Overall, this opportunity supported the continuation of a uniquely valuable, long-duration community cohort designed to generate actionable public health evidence on who develops hip and knee osteoarthritis, why it happens, how it worsens, and how patterns and drivers of OA may differ by race or ethnicity.
Frequently Asked Questions (FAQs)
What is the Johnston County Osteoarthritis Project (U01) grant opportunity?
This funding opportunity supported the continuation of the Johnston County Osteoarthritis Project, a long-running, population-based, longitudinal public health study focused on osteoarthritis (OA). It was a CDC discretionary funding announcement under a cooperative agreement mechanism (U01).
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number listed for this announcement is RFA DP 11 005.
Which federal agency offered this funding opportunity?
The opportunity was offered by the Centers for Disease Control and Prevention (CDC).
What is the main purpose of the project?
The core purpose was to continue and strengthen a community cohort in Johnston County, North Carolina, to understand how hip and knee OA develops over time, how common it is, what factors affect risk, and how the disease progresses after onset.
Why was a long-term, population-based cohort emphasized?
The announcement emphasized maintaining a consistent cohort and repeatedly measuring outcomes over many years. This design can generate more reliable evidence than short-term or clinic-based studies, especially for chronic conditions like OA where onset and progression may unfold slowly.
What joints and conditions were the focus of this study?
The study focused on osteoarthritis (OA) of the hip and knee, including how often it occurs, how it develops, and how it progresses over time.
What were the main research aims described in the announcement?
The aims emphasized two areas: (1) estimating and tracking prevalence and incidence of hip and knee OA and identifying risk factors associated with occurrence and progression, and (2) examining racial or ethnic differences in OA outcomes and in how risk factors influence those outcomes.
What does prevalence mean in the context of this project?
Prevalence refers to how many people have osteoarthritis at a given time.
What does incidence mean in the context of this project?
Incidence refers to how many new cases of osteoarthritis arise over time.
What types of risk factors were expected to be studied?
The announcement indicated risk factors could include demographic characteristics, body weight and physical activity patterns, history of joint injury, occupational or biomechanical stresses, comorbid health conditions, and other exposures that may influence joint health across the lifespan.
How did the opportunity address racial or ethnic differences and health disparities?
The project was expected to evaluate whether disease burden, symptoms, functional impacts, progression patterns, and the influence of specific risk factors differ across racial or ethnic groups. This focus was presented as central to understanding and addressing health disparities.
What funding mechanism was used, and what does it imply?
The mechanism was a cooperative agreement (U01). This typically indicates substantial federal scientific or programmatic involvement during the project period compared with a standard grant.
What was the funding activity category and CFDA number?
The funding activity category was Health. The CFDA listing provided was 93.283 (CDC Investigations and Technical Assistance).
How many awards did CDC anticipate making under this announcement?
CDC anticipated making a single award.
What was the estimated total funding level and the award ceiling?
The estimated total funding level was $3,250,000, and the award ceiling was $750,000.
Was cost-sharing or matching required?
No cost-sharing or matching requirement was indicated.
Who was eligible to apply for this grant opportunity?
Eligibility was explicitly limited to the University of North Carolina at Chapel Hill.
Why was eligibility limited to UNC Chapel Hill?
The rationale given was that UNC Chapel Hill was the only institution positioned to continue following the established 20-year cohort and to leverage existing federal and private resources connected to the study. The limitation was tied to the importance of continuity in long-term cohort research, including maintaining the same participant base, measurement protocols, and historical data infrastructure.
When was the announcement posted?
The announcement was posted on December 2, 2010.
What was the application deadline?
The application deadline was March 4, 2011.
How were applications required to be submitted?
Applications were required to be submitted through Grants.gov.
Was there a specific time requirement for submission and validation?
Yes. Submission through Grants.gov and validation were required by 5:00 p.m. Eastern Time on the due date.
When was the opportunity archived?
The opportunity was archived on April 3, 2011.
Who should be contacted for access issues related to the full announcement?
For access issues, applicants were directed to CDC's Procurement and Grants Office, Technical Information and Management Section (TIMS).
What contact information was provided for CDC TIMS?
The phone number provided was 770-488-2700. The notice also referenced a general email field for TIMS.
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