Opportunity Information: Apply for 12 561

  • The National Science Foundation in the science and technology and other research and development sector is offering a public funding opportunity titled "Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 47.049 Mathematical and Physical Sciences 93.859 Biomedical Research and Research Training.
  • This funding opportunity was created on May 24, 2012 and posted on May 24, 2012.
  • Applicants must submit their applications by Sep 17, 2012 Full Proposal Deadline(s) September 17, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
  • The number of recipients for this funding is limited to 20 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for 12 561

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Opportunity Summary:

The Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences (Funding Opportunity Number 12-561) is a discretionary grant competition led by the National Science Foundation (NSF), specifically its Division of Mathematical Sciences (DMS) within the Directorate for Mathematical and Physical Sciences, in partnership with the National Institutes of Health (NIH) through the National Institute of General Medical Sciences (NIGMS). The central purpose of the opportunity is to fund research in mathematics and statistics that tackles important questions arising in the biological and biomedical sciences. In practical terms, the program is meant to move beyond math as a supporting tool and instead promote deep, integrated work where mathematical or statistical innovation and biological insight genuinely inform each other.

A key theme of the solicitation is urgency and strategic need: both NSF and NIH emphasize that modern biological and biomedical problems increasingly demand strong quantitative approaches, whether that means developing new mathematical theory, building statistical methods suited to complex biological data, or creating computational and modeling frameworks that can explain, predict, or control biological phenomena. The competition explicitly aims to strengthen the pipeline of interdisciplinary research by both encouraging brand-new collaborations and helping established interdisciplinary teams continue and expand their efforts. That dual focus matters because it signals openness to proposals at different stages of maturity, from early partnership-building to more advanced projects with a proven joint track record, as long as the work sits squarely at the math-biology interface.

This is a research and development funding opportunity (Science and Technology and other Research and Development) using the grant funding instrument. The program anticipated making about 20 awards, with an estimated total funding level of $5,000,000. Individual awards could range from a nominal floor of $1 up to a ceiling of $2,000,000, indicating that budgets could vary widely depending on scope, while still allowing for large, multi-year interdisciplinary projects where justified. Importantly, there is no cost sharing or matching requirement, which typically reduces barriers for applicants and can make the program more accessible across institution types.

Eligibility is listed as unrestricted, meaning it is open to any type of entity, subject to any additional eligibility clarifications in the full program text (referenced as NSF Publication 12-561). The solicitation is connected to two CFDA program areas: 47.049 (Mathematical and Physical Sciences) and 93.859 (Biomedical Research and Research Training). That pairing reinforces the intended cross-agency, cross-disciplinary nature of the work, and it also hints at the kinds of review perspectives proposals may encounter: applicants generally need to make a convincing case that the project advances mathematical or statistical science while also addressing substantive biological or biomedical questions.

The opportunity was posted on May 24, 2012, with a full proposal deadline of September 17, 2012, and it was archived on October 17, 2012. For applicants needing technical help accessing the announcement, NSF directed inquiries to Grants.gov support at grantsgovsupport@nsf.gov, and provided additional contact guidance for linking issues in the original notice.

FAQs: Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences (NSF 12-561)

What is this funding opportunity?

This is a discretionary government grant competition titled "The Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences" (Funding Opportunity Number 12-561). It supports research and development projects in science and technology.

Which agencies are involved?

The competition is led by the National Science Foundation (NSF), specifically the Division of Mathematical Sciences (DMS) within the Directorate for Mathematical and Physical Sciences, in partnership with the National Institutes of Health (NIH) through the National Institute of General Medical Sciences (NIGMS).

What is the main purpose of the program?

The central purpose is to fund research in mathematics and statistics that addresses important questions arising in the biological and biomedical sciences, with an emphasis on truly integrated work at the math-biology interface.

What does "research at the interface" mean in this program?

Based on the solicitation description, the program is designed to move beyond mathematics as a supporting tool. It promotes projects where mathematical or statistical innovation and biological insight genuinely inform each other, resulting in deeper interdisciplinary advances.

What kinds of research does this program emphasize?

The emphasis is on modern biological and biomedical problems that require strong quantitative approaches, including developing new mathematical theory, creating statistical methods tailored to complex biological data, and building computational or modeling frameworks that can explain, predict, or control biological phenomena.

Is the program meant only for new collaborations?

No. The program explicitly aims to strengthen the pipeline of interdisciplinary research by encouraging brand-new collaborations and also helping established interdisciplinary teams continue and expand their efforts.

How many awards were expected to be made?

The program anticipated making about 20 awards.

What was the estimated total funding level?

The estimated total funding level was $5,000,000.

What is the award size range?

Individual awards could range from a nominal minimum of $1 up to a maximum of $2,000,000, indicating that budgets could vary widely depending on the proposed scope.

Does this opportunity require cost sharing or matching funds?

No. The opportunity states there is no cost sharing or matching requirement.

What type of funding instrument is used?

This opportunity uses the grant funding instrument.

What is the program classification for this opportunity?

It is classified as a research and development funding opportunity under "Science and Technology and other Research and Development."

Who is eligible to apply?

Eligibility is listed as unrestricted, meaning it is open to any type of entity, subject to any additional eligibility clarifications contained in the full program text (NSF Publication 12-561).

Where are additional eligibility details found?

Additional eligibility clarifications, if any, are referenced as being in the full program text identified as NSF Publication 12-561.

Which CFDA program areas are associated with this solicitation?

The solicitation is connected to two CFDA program areas: 47.049 (Mathematical and Physical Sciences) and 93.859 (Biomedical Research and Research Training).

What does the pairing of CFDA areas suggest about the program?

The pairing reinforces that the program is cross-agency and cross-disciplinary. It also suggests proposals may be considered from both mathematical sciences and biomedical research perspectives, so projects generally need to speak convincingly to both sides of the interface.

When was the opportunity posted?

The opportunity was posted on May 24, 2012.

What was the full proposal deadline?

The full proposal deadline was September 17, 2012.

When was the opportunity archived?

The opportunity was archived on October 17, 2012.

Where could applicants get technical help accessing the announcement?

For technical help accessing the announcement, NSF directed inquiries to Grants.gov support at grantsgovsupport@nsf.gov.

What should applicants do if they had problems linking to the announcement?

The notice indicated there was additional contact guidance for linking issues in the original announcement, and that technical inquiries could be directed to Grants.gov support at grantsgovsupport@nsf.gov.

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