Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences | Apply Online

Opportunity Summary:

The Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences is a discretionary grant opportunity led by the National Science Foundation (NSF), specifically the Division of Mathematical Sciences (DMS) within the Directorate for Mathematical and Physical Sciences, in partnership with the National Institutes of Health (NIH) through the National Institute of General Medical Sciences (NIGMS). The central aim is to fund research that uses mathematics and statistics to tackle important questions in the biological and biomedical sciences. The opportunity is built around the idea that modern life science problems increasingly require rigorous quantitative approaches, and that progress often depends on close collaboration between mathematical scientists and biologists or biomedical researchers.

The program is explicitly meant to strengthen and expand research at the mathematical-biology interface. It is designed both to spark new interdisciplinary collaborations and to provide continued support for teams that already work across these fields. In practical terms, proposals are expected to bring mathematical and statistical innovation to biological or biomedical questions, or to develop new mathematical theory motivated by real biological complexity, with both sides of the collaboration meaningfully shaping the research direction. The agencies frame this as an urgent need, signaling that they are looking for work that goes beyond routine application of existing tools and instead advances the way quantitative methods can drive discovery in the life sciences.

From a funding mechanics standpoint, this is a grant program categorized under Science and Technology and other Research and Development. The opportunity lists an estimated total funding amount of $5,000,000 and anticipates making about 20 awards. Individual award sizes range from a floor of $1 to a ceiling of $2,000,000, indicating flexibility in project scale, from small exploratory efforts to larger, more ambitious collaborations. There is no cost sharing or matching requirement, which reduces barriers for applicants and places the emphasis on scientific merit and project fit rather than institutional cost commitments.

Eligibility is listed as unrestricted, meaning it is broadly open to any type of applicant entity, subject to any additional eligibility clarifications in the full solicitation text. The listing includes two CFDA numbers reflecting the joint nature of the effort and its disciplinary reach: 47.049 (Mathematical and Physical Sciences) and 93.859 (Biomedical Research and Research Training). That pairing reinforces that the funded projects are expected to sit squarely between mathematical sciences and biomedical relevance, rather than being purely one or the other.

Key dates show that the opportunity was posted on July 9, 2013, with multiple full proposal deadlines across three years: September 23, 2013; September 15, 2014; and September 15, 2015. The archive date is October 15, 2015, meaning it is no longer open for new submissions, but the details remain useful as a reference for similar current or future interdisciplinary programs. The official reference for the full announcement is NSF Publication 13-570 (Funding Opportunity Number 13-570), which would contain the complete program description, submission requirements, review criteria, and any special instructions for joint NSF-NIH handling.

For support and access issues, the announcement points applicants to NSF Grants.gov support (grantsgovsupport@nsf.gov) for technical difficulties accessing the notice electronically or problems linking to the funding announcement. The administering agency is NSF, but the partnership with NIH/NIGMS is a defining feature, and applicants would typically need to pay close attention in the full solicitation to how proposals are assigned, reviewed, and potentially co-funded across the two agencies.

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