Opportunity Information: Apply for PAR 07 412
Apply for PAR 07 412
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Large Scale Collaborative Project Awards (R24/U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Dec 3, 2008 and posted on Dec 3, 2008.
- Applicants must submit their applications by Jun 17, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Large Scale Collaborative Project Awards (R24/U54), also known as "glue grants," are a National Institute of General Medical Sciences (NIGMS) funding opportunity designed to tackle critical, complex biological problems that fall within the NIGMS mission. The central idea is to bring together a team of investigators who are already independently funded and help them work as a tightly integrated consortium. Rather than supporting a single laboratory or a loosely connected network, this program emphasizes synergy, coordination, and shared strategy so that the group can solve problems that would be difficult or unrealistic for individual research groups to handle on their own.
The program is structured in two phases. Phase I is intended for planning and coordination, recognizing that building a large, effective consortium takes deliberate design before major research funds are committed. Phase I provides up to $50,000 in direct costs for up to one year, which can be used to organize the collaboration, refine the scientific goals, establish governance and management approaches, and map out how the different projects and investigators will integrate into one comprehensive research plan. This planning period is meant to reduce risk and increase the likelihood that a full-scale effort will be genuinely collaborative rather than a collection of separate projects.
Phase II supports the full research effort and provides very large-scale resources to enable an ambitious, integrated approach. Because the scientific scope can differ dramatically across proposed consortium projects, NIGMS anticipates that Phase II awards will vary in both size and duration. That said, the program sets clear funding caps: the maximum Phase II award is $25 million in direct costs over a five-year period. If an application proposes fewer than five years, it may not exceed an average of $5 million per year in direct costs, and direct costs for any single year may not exceed $7 million. These limits reflect the program's intent to support comprehensive, high-impact collaborations with enough resources to coordinate multiple teams, approaches, and potentially shared infrastructure. An important budgeting detail is that indirect costs associated with consortium arrangements are not counted toward the maximum direct-cost amounts, which can make it easier to structure multi-institution collaborations without immediately hitting the cap.
Administratively, this opportunity is offered by the National Institutes of Health (NIH) under NIGMS and uses the cooperative agreement mechanism, meaning NIH is expected to have substantial involvement in the funded project compared to a standard grant. The funding opportunity number is PAR-07-412, categorized as discretionary funding, with an activity focus in health and biomedical research and research training (CFDA 93.859). There is no cost sharing or matching requirement, which simplifies participation for eligible organizations.
Eligibility is broad and includes many types of U.S.-based institutions and organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits), state governments, and a variety of mission-serving and community-based entities. The announcement specifically notes additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal governments and tribal organizations (including those other than federally recognized tribal governments), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. This broad eligibility reflects the program's interest in enabling large collaborations that may span institutions, regions, and organizational types, as long as the proposed work aligns with NIGMS priorities.
Key dates associated with the posting indicate this announcement was posted and created on December 3, 2008, with an original and current closing date of June 17, 2010, and an archive date of July 18, 2010. The full announcement was available through the NIH grants guide at the link provided in the source text, and NIH listed standard contact support through the NIH Office of Extramural Research (OER) webmaster for access or technical linking issues.
FAQs: NIGMS Large Scale Collaborative Project Awards (R24/U54) "Glue Grants" (PAR-07-412)
What is the Large Scale Collaborative Project Awards (R24/U54) program?
It is a National Institute of General Medical Sciences (NIGMS) funding opportunity at the National Institutes of Health (NIH) designed to support large, tightly integrated research consortia that address critical, complex biological problems within the NIGMS mission. These awards are commonly referred to as "glue grants" because they are intended to bind together independently funded investigators into a coordinated, synergistic team.
What is the main purpose of these "glue grants"?
The purpose is to enable a group of investigators (who are already independently funded) to work as a unified consortium with shared strategy, coordination, and governance. The program emphasizes true integration and synergy rather than a single-lab project or a loosely connected network of separate projects.
What kinds of problems is this program meant to tackle?
The program targets critical and complex biological problems that fall within the NIGMS mission and that would be difficult or unrealistic for individual research groups to solve on their own.
How is the program structured?
The opportunity is structured in two phases: Phase I (planning and coordination) and Phase II (full-scale consortium research effort).
What is Phase I designed to support?
Phase I supports planning and coordination activities needed to deliberately design a large, effective consortium before major research funds are committed. It is meant to reduce risk and improve the chances that Phase II will be genuinely collaborative and integrated.
How much funding is available in Phase I?
Phase I provides up to $50,000 in direct costs.
How long can Phase I last?
Phase I can support up to one year of planning and coordination.
What can Phase I funds be used for?
Based on the announcement description, Phase I direct costs may be used to organize the collaboration, refine the scientific goals, establish governance and management approaches, and map out how the different projects and investigators will integrate into one comprehensive research plan.
What does Phase II support?
Phase II supports the full research effort of the large-scale, integrated consortium and provides large-scale resources to execute the ambitious collaborative plan developed during the planning stage.
How large can a Phase II award be?
The maximum Phase II award is $25 million in direct costs over a five-year period.
Can Phase II projects be shorter than five years?
Yes. NIGMS anticipates Phase II awards may vary in duration and size. If an application proposes fewer than five years, it may not exceed an average of $5 million per year in direct costs.
Is there a limit on direct costs in any single year for Phase II?
Yes. Direct costs for any single year may not exceed $7 million.
Are indirect costs included in the Phase II direct-cost cap?
No. The announcement specifies that indirect costs associated with consortium arrangements are not counted toward the maximum direct-cost amounts, which can help multi-institution consortia structure budgets without hitting the direct-cost cap as quickly.
Does the program require cost sharing or matching funds?
No. The opportunity states there is no cost sharing or matching requirement.
What funding mechanism does NIH use for this opportunity?
This opportunity uses the cooperative agreement mechanism. That means NIH is expected to have substantial involvement in the funded project compared to a standard grant.
Who is offering the opportunity?
The opportunity is offered by NIH under the National Institute of General Medical Sciences (NIGMS).
What is the funding opportunity number?
The funding opportunity number is PAR-07-412.
How is this opportunity categorized in terms of funding type and focus?
It is categorized as discretionary funding, with an activity focus in health and biomedical research and research training. The CFDA number listed is 93.859.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based institutions and organizations, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), and state governments. The announcement also includes a range of mission-serving and community-based entities.
Are minority-serving institutions specifically listed as eligible?
Yes. The announcement specifically notes eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are tribal governments and tribal organizations eligible?
Yes. The announcement lists tribal governments and tribal organizations, including those other than federally recognized tribal governments.
Are faith-based or community-based organizations eligible?
Yes. The announcement explicitly includes faith-based or community-based organizations among eligible applicants.
Are regional organizations eligible?
Yes. Regional organizations are listed among eligible applicants.
Are federal agencies eligible?
Yes. The announcement includes eligible federal agencies.
Are U.S. territories or possessions eligible to apply?
Yes. The announcement includes U.S. territories or possessions.
What is the intended team composition for a project under this program?
The central concept is to assemble a team of investigators who are already independently funded and enable them to work as a tightly integrated consortium, emphasizing coordination, shared strategy, and synergy.
How does this program differ from a loosely connected research network?
Instead of funding separate projects that happen to be related, this program emphasizes deliberate integration: shared goals, coordinated management, and a unified research plan that enables outcomes that individual labs or loosely connected groups would have difficulty achieving.
When was this announcement posted and created?
The posting and creation date listed is December 3, 2008.
What were the closing dates for this opportunity?
The original closing date and the current closing date listed are both June 17, 2010.
When was the opportunity archived?
The archive date listed is July 18, 2010.
Where was the full announcement made available?
The full announcement was available through the NIH grants guide via the link referenced in the source text.
Who is listed for technical help or access issues?
NIH lists standard contact support through the NIH Office of Extramural Research (OER) webmaster for access or technical linking issues.
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