Opportunity Information: Apply for RFA MH 15 400

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Leveraging a Recovery Act Resource to Accelerate Research on Neurodevelopment (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
  • This funding opportunity was created on Mar 24, 2014 and posted on Mar 24, 2014.
  • Applicants must submit their applications by Sep 3, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $350,000.00 in funding.
  • Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Independent school districts State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) County governments City or township governments Small businesses Private institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The grant opportunity "Leveraging a Recovery Act Resource to Accelerate Research on Neurodevelopment (R01)" (Funding Opportunity Number RFA-MH-15-400) is a National Institutes of Health (NIH) research grant designed to push more scientists to use a major neurodevelopment data resource that was originally funded through the American Recovery and Reinvestment Act of 2009. The central purpose is to speed up discovery by making sure this existing, publicly valuable dataset is widely used to test new ideas about how development unfolds in the brain and how risk for mental illness emerges over time. Rather than funding brand-new data collection as the primary focus, the program is positioned around leveraging a high-value, already-funded resource to answer important developmental neuroscience and psychiatric questions faster and with broader participation from the research community.

Scientifically, the FOA targets research that can generate and evaluate hypotheses about complex, multi-directional relationships across several domains that change as children and adolescents develop. The key domains named in the announcement include genetics, brain maturation, neurocognitive functioning, and psychiatric symptoms. The emphasis on "complex interrelationships" and "multi directional influences" signals that NIH is looking for integrative developmental models, not just simple one-way explanations. Projects are expected to examine how factors like genetic variation and brain development may influence cognition and behavior, how emerging psychiatric symptoms may in turn affect developmental trajectories, and how these processes interact across time. In practical terms, strong applications would likely use longitudinal and multivariate approaches, explore developmental timing and sensitive periods, and test mechanistic pathways or predictive models that connect biology, brain systems, cognition, and symptoms.

A major strategic goal of this initiative is dissemination and broad uptake of the Recovery Act-supported dataset, treating it as a community resource that can drive many independent lines of inquiry. NIH is explicitly trying to widen the pool of investigators and disciplines working with this data, which can help prevent the resource from being used only by the original or closely related research groups. The FOA also puts clear weight on collaborative science, encouraging teams that bring together diverse expertise such as neuroimaging, genomics, developmental psychology, psychiatry, statistics, data science, and computational modeling. Alongside collaboration, the announcement highlights interest in expanding the diversity of research questions and analytic approaches, meaning applicants are encouraged to be creative and to propose novel or underused methods as long as they are rigorous and appropriate for the dataset.

Methodological advancement is another priority. The FOA explicitly mentions integration across data modalities and levels of analysis, including imaging, genomics, and behavior. This indicates that competitive projects may involve harmonizing measures across modalities, developing or applying methods that connect genetic data to brain structure or function, linking imaging markers to cognitive tasks and symptom measures, or building multi-level models that can handle high-dimensional data. Proposals that improve the field's ability to integrate and interpret these layered data types, while still answering concrete neurodevelopmental questions, align closely with what the opportunity describes as secondary goals.

The FOA also encourages the inclusion of early stage investigators within collaborations. That language generally reflects an interest in workforce development and in building durable capacity in the community to analyze complex neurodevelopmental datasets. While the program is not exclusively reserved for new investigators, applicants who intentionally structure collaborations that provide meaningful leadership or analytic roles for early career researchers may fit well with the spirit of the announcement.

From an administrative and funding standpoint, this is an R01 grant mechanism under the NIH with a discretionary funding category and a health-focused activity code (CFDA 93.242, Mental Health Research Grants). The opportunity was posted March 24, 2014, with an original and current closing date of September 3, 2014, and an archive date of October 4, 2014, indicating it is no longer open but remains useful as a reference for the program's aims and structure. The estimated total funding listed is $1,500,000, and the award ceiling is $350,000. The FOA specifies that there is no cost sharing or matching requirement, which means applicants were not expected to contribute non-federal funds as a condition of the award.

Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (other than small businesses), small businesses, independent school districts, and multiple levels of government (state, county, city/township, special district). The eligibility list also explicitly includes tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a variety of minority-serving institutions such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian serving institutions, and tribally controlled colleges and universities. Faith-based and community-based organizations are also included. Importantly, the FOA allows non-U.S. entities (foreign organizations and foreign institutions) to apply, allows non-domestic components of U.S. organizations, and permits foreign components as defined in NIH policy, reflecting an intent to maximize scientific participation and analytic innovation regardless of geography, as long as applicants meet NIH requirements.

Overall, this funding opportunity is best understood as a targeted effort to capitalize on a major federal investment made during the Recovery Act period by turning a rich neurodevelopment dataset into an engine for broader, faster progress in understanding developmental trajectories and mental illness risk. It pushes the field toward integrative, multi-modal, developmentally informed science; it encourages methodological and analytic innovation for combining genomics, imaging, behavioral, and clinical symptom data; and it aims to build wider, more collaborative research networks that include early stage investigators and diverse institutions. For the full historical announcement and detailed requirements, NIH provided the link: http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-15-400.html, with NIH OER Webmaster contacts for access or technical linking issues (FBOWebmaster@OD.NIH.GOV).

Frequently Asked Questions (FAQs)

What is the name of this grant opportunity?

The opportunity is titled "Leveraging a Recovery Act Resource to Accelerate Research on Neurodevelopment (R01)."

What is the funding opportunity number?

The Funding Opportunity Number is RFA-MH-15-400.

Which agency is offering this opportunity?

This is a National Institutes of Health (NIH) research grant opportunity.

What is the main purpose of this FOA?

The central purpose is to accelerate discovery by encouraging broad use of a major neurodevelopment data resource that was originally funded through the American Recovery and Reinvestment Act of 2009. The FOA is designed to increase the number and diversity of scientists using an existing, high-value dataset to test new ideas about brain development and how risk for mental illness emerges over time.

Is this grant intended to fund brand-new data collection?

No. The program is positioned around leveraging an already-funded resource rather than making brand-new data collection the primary focus.

What types of scientific questions is NIH trying to support with this FOA?

The FOA targets research that generates and evaluates hypotheses about complex, multi-directional relationships across domains that change as children and adolescents develop, including genetics, brain maturation, neurocognitive functioning, and psychiatric symptoms.

Which scientific domains are explicitly named in the FOA description provided?

The named domains include genetics, brain maturation, neurocognitive functioning, and psychiatric symptoms.

What does the FOA mean by "complex interrelationships" and "multi-directional influences"?

Based on the description provided, NIH is looking for integrative developmental models rather than simple one-way explanations. Projects are expected to consider how factors may influence each other over time (for example, how genetic variation and brain development may influence cognition and behavior, and how emerging psychiatric symptoms may also shape developmental trajectories).

Does the FOA emphasize development over time?

Yes. The description emphasizes understanding how development unfolds across childhood and adolescence and how risk for mental illness emerges over time, with attention to changing relationships across domains across time.

Is broad dissemination and uptake of the dataset a goal of the program?

Yes. A major strategic goal is dissemination and broad uptake of the Recovery Act-supported dataset as a community resource, widening participation beyond the original or closely related research groups.

Does the FOA encourage collaboration?

Yes. The announcement encourages collaborative science and teams that bring together diverse expertise.

What kinds of expertise does the FOA encourage teams to include?

The provided description highlights expertise such as neuroimaging, genomics, developmental psychology, psychiatry, statistics, data science, and computational modeling.

Does the FOA encourage methodological or analytic innovation?

Yes. The FOA highlights interest in expanding the diversity of analytic approaches and encourages novel or underused methods as long as they are rigorous and appropriate for the dataset.

What kinds of data integration does the FOA prioritize?

The FOA explicitly mentions integration across data modalities and levels of analysis, including imaging, genomics, and behavior.

Are multi-modal or multi-level models relevant to this opportunity?

Yes. The description indicates interest in approaches that connect genetic data to brain structure or function, link imaging markers to cognitive tasks and symptom measures, and build models that can handle layered or high-dimensional data while answering concrete neurodevelopmental questions.

Is inclusion of early stage investigators encouraged?

Yes. The FOA encourages inclusion of early stage investigators within collaborations, reflecting an interest in workforce development and building durable community capacity to analyze complex neurodevelopmental datasets.

Is this opportunity limited only to early stage investigators?

No. The description indicates it is not exclusively reserved for new investigators, but collaborations that provide meaningful roles for early career researchers align with the spirit of the announcement.

What grant mechanism is used for this opportunity?

This is an NIH R01 grant mechanism.

What is the CFDA number and program area noted?

The CFDA is 93.242, labeled as Mental Health Research Grants.

How much total funding was estimated for this FOA?

The estimated total funding listed is $1,500,000.

What is the award ceiling?

The award ceiling is $350,000.

Is cost sharing or matching required?

No. The FOA specifies there is no cost sharing or matching requirement.

When was the opportunity posted?

The opportunity was posted on March 24, 2014.

What were the closing date and current closing date?

The original and current closing date listed is September 3, 2014.

Is this funding opportunity still open?

No. The archive date is October 4, 2014, indicating the opportunity is no longer open and is primarily useful as a historical reference for the program's aims and structure.

Who is eligible to apply?

Eligibility is broad. The listed eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (other than small businesses), small businesses, independent school districts, and multiple levels of government (state, county, city/township, special district).

Are tribal governments and tribal organizations eligible?

Yes. The eligibility list explicitly includes tribal governments and tribal organizations.

Are public housing authorities eligible?

Yes. Public housing authorities/Indian housing authorities are explicitly included in the eligibility list.

Are minority-serving institutions eligible?

Yes. The eligibility list explicitly includes a variety of minority-serving institutions, including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian serving institutions, and tribally controlled colleges and universities.

Are faith-based and community-based organizations eligible?

Yes. Faith-based and community-based organizations are included.

Are non-U.S. (foreign) organizations allowed to apply?

Yes. The FOA allows non-U.S. entities (foreign organizations and foreign institutions) to apply.

Can a U.S. organization include a non-domestic component or foreign component?

Yes. The FOA allows non-domestic components of U.S. organizations and permits foreign components as defined in NIH policy.

Where can the full historical FOA announcement be found?

The FOA link provided is http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-15-400.html.

Who is the contact for access or technical linking issues?

The NIH OER Webmaster contact provided for access or technical linking issues is FBOWebmaster@OD.NIH.GOV.

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