Opportunity Information: Apply for RFA MH 16 150
Apply for RFA MH 16 150
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Lifespan Human Connectome Project Development (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.361 Nursing Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Feb 6, 2015 and posted on Feb 6, 2015.
- Applicants must submit their applications by Jun 15, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education Special district governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments State governments City or township governments Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Lifespan Human Connectome Project Development (U01) opportunity (Funding Opportunity Number RFA-MH-16-150) is an NIH Blueprint for Neuroscience Research initiative aimed at expanding the well-known Human Connectome Project (HCP) into a fuller, lifespan-oriented effort. The NIH Blueprint is a cross-NIH collaboration involving 15 Institutes, Centers, and Offices that pool resources to support neuroscience research with the broader aim of speeding discovery and ultimately reducing the burden of disorders of the nervous system. In practical terms, this FOA is part of the Blueprint's plan to build a consistent, high-quality map of brain connectivity not only in healthy young adults (the original HCP focus), but across key stages of life.
The scientific purpose of this specific FOA is to push the HCP experimental and imaging protocols into pediatric populations, specifically children and adolescents, in order to characterize typical developmental changes in brain structure and function. The emphasis is on extending and adapting protocols that were developed and validated in the original HCP so that the resulting data can be comparable across studies and, eventually, across the lifespan. By doing so, the program is positioned to produce standardized datasets and methods for understanding how neural circuits and networks develop during childhood and adolescence, including changes in structural connectivity (white matter pathways and anatomical connections) and functional connectivity (how brain regions co-activate and communicate over time).
This announcement sits within a larger Lifespan Human Connectome Project (L-HCP) vision that includes development, adulthood, and aging. A companion FOA is mentioned for middle-aged and older adults, focusing on connectivity changes during normal aging. Together, the paired efforts reflect a coordinated strategy: use harmonized HCP-style methods to create a coherent picture of brain connectivity trajectories from early life through late life, enabling better cross-age comparisons and providing foundational reference data for later studies of disease risk and neurological or psychiatric disorders.
From an administrative and funding standpoint, the mechanism is a U01 cooperative agreement, meaning NIH expects to have substantial programmatic involvement compared with a standard research project grant. The opportunity is categorized as discretionary funding, and it anticipated a single award (ExpectedAwards: 1), suggesting a concentrated, centrally coordinated project rather than many independent grants. There is no cost sharing or matching requirement. The posting and creation date were February 6, 2015, with an original and current closing date of June 15, 2015, and an archive date of July 16, 2015, indicating this was a time-limited competition that is now closed.
Eligibility is broad and includes many types of domestic U.S. organizations and governments, such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses, for-profit entities (other than small businesses are listed as eligible), independent school districts, and multiple levels of government (city/township, county, state), as well as special district governments and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes a range of mission-focused and community-rooted institutions and groups, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations. The FOA also notes that non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and eligible federal agencies may apply, highlighting an intent to allow a wide applicant pool as long as the proposed work aligns with the program goals and logistical requirements.
The program is administered under the National Institutes of Health, and it is associated with multiple CFDA program areas spanning neuroscience and health-related domains (including mental health, child health and human development, aging, neurological disorders, vision research, nursing research, and technology innovations to improve human health, among others). This range reflects the inherently cross-cutting nature of connectomics and neurodevelopmental research, where advances in imaging, data standards, and developmental neuroscience can inform many biomedical fields.
For applicants and interested parties, the primary official details were provided through NIH's online Grants Guide announcement page (linked in the FOA). Technical access issues were routed to the NIH Office of Extramural Research (OER) webmaster contacts listed in the notice.
Frequently Asked Questions (FAQs): Lifespan Human Connectome Project Development (U01) - RFA-MH-16-150
What is this funding opportunity?
This opportunity is the Lifespan Human Connectome Project Development (U01), Funding Opportunity Number (FON) RFA-MH-16-150. It is an NIH Blueprint for Neuroscience Research initiative designed to expand the original Human Connectome Project (HCP) into a broader, lifespan-oriented effort.
What is the NIH Blueprint for Neuroscience Research?
The NIH Blueprint is a cross-NIH collaboration that includes 15 Institutes, Centers, and Offices. These groups pool resources to support neuroscience research with the goal of accelerating discovery and ultimately reducing the burden of disorders of the nervous system.
How does this relate to the original Human Connectome Project (HCP)?
The original HCP focused on mapping brain connectivity in healthy young adults. This funding opportunity supports extending and adapting those established HCP experimental and imaging protocols so they can be used in children and adolescents, while keeping the resulting data comparable to the original HCP datasets.
What is the main scientific purpose of this FOA?
The core purpose is to push HCP protocols into pediatric populations (children and adolescents) to characterize typical developmental changes in brain structure and function. A major emphasis is harmonization: adapting validated HCP-style methods so cross-study and eventual cross-lifespan comparisons are possible.
What age groups are targeted by this specific announcement?
This FOA emphasizes pediatric populations, specifically children and adolescents, with the goal of understanding typical neurodevelopmental changes during childhood and adolescence.
What kinds of brain connectivity does the project aim to characterize?
The program highlights both:
- Structural connectivity (for example, white matter pathways and anatomical connections)
- Functional connectivity (how brain regions co-activate and communicate over time)
Why is protocol comparability across studies important here?
A stated goal is to extend protocols developed and validated in the original HCP so that pediatric data can be comparable across studies and, ultimately, across the lifespan. This comparability supports standardized datasets and methods for understanding developmental trajectories of neural circuits and networks.
How does this FOA fit into the broader Lifespan Human Connectome Project (L-HCP) vision?
This announcement is part of a larger L-HCP plan covering development, adulthood, and aging. The intent is a coordinated strategy using harmonized HCP-style methods to create a coherent picture of brain connectivity trajectories from early life through late life.
Is there a related funding opportunity for other age ranges?
Yes. The description references a companion FOA for middle-aged and older adults that focuses on connectivity changes during normal aging. Together, the paired efforts support connectivity mapping across key life stages.
What is the funding mechanism for this opportunity?
The mechanism is a U01 cooperative agreement. This implies NIH expects substantial programmatic involvement compared with a standard research project grant.
What does "cooperative agreement" imply for NIH involvement?
Based on the opportunity description, a U01 cooperative agreement means NIH anticipates a higher level of involvement in programmatic aspects than under a typical research project grant, consistent with a centrally coordinated effort.
How many awards were expected?
The opportunity anticipated a single award (ExpectedAwards: 1), indicating a concentrated project rather than multiple independent awards.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What type of funding is this categorized as?
It is categorized as discretionary funding.
Is this funding opportunity still open?
No. The posting/creation date was February 6, 2015, the closing date was June 15, 2015 (original and current), and the archive date was July 16, 2015. These dates indicate the competition was time-limited and is now closed.
Who administers this program?
The program is administered under the National Institutes of Health (NIH) and is part of the NIH Blueprint for Neuroscience Research.
What kinds of organizations were eligible to apply?
Eligibility was broad and included many types of U.S. domestic organizations and governments, including:
- Public and private institutions of higher education
- Nonprofits (501(c)(3) and non-501(c)(3))
- Small businesses
- For-profit entities (including those other than small businesses, as listed)
- Independent school districts
- City/township, county, and state governments
- Special district governments
- Public housing authorities / Indian housing authorities
Are community-rooted and mission-focused institutions included in eligibility?
Yes. The eligibility language explicitly includes groups such as HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, and also faith-based or community-based organizations.
Could non-U.S. or international entities apply?
Yes. The eligibility language notes that non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and eligible federal agencies may apply.
What NIH program areas or CFDA-related domains are associated with this opportunity?
The opportunity is associated with multiple program areas spanning neuroscience and health-related domains, including mental health, child health and human development, aging, neurological disorders, vision research, nursing research, and technology innovations to improve human health. This reflects the cross-cutting nature of connectomics and neurodevelopmental research.
Where were the official details published?
The primary official details were provided through the NIH online Grants Guide announcement page referenced in the FOA.
Who should be contacted for technical access issues related to the announcement?
Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contacts listed in the notice.
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