Opportunity Information: Apply for PAR 12 055

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Limited Competition Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.397 Cancer Centers Support Grants 93.398 Cancer Research Manpower 93.399 Cancer Control.
  • This funding opportunity was created on Dec 9, 2011 and posted on Dec 9, 2011.
  • Applicants must submit their applications by Jan 28, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Apply for PAR 12 055

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Opportunity Summary:

The Limited Competition Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54) opportunity (Funding Opportunity Number PAR 12-055) is a National Cancer Institute (NCI) cooperative agreement program designed to deepen and formalize long-term collaborations between institutions that serve communities experiencing cancer health disparities and NCI-designated Cancer Centers (or consortia of Cancer Centers). The central goal is to build stronger, more connected national cancer research and training efforts that can better explain why major cancer disparities persist across certain populations and then translate that understanding into practical improvements in prevention, detection, diagnosis, treatment, survivorship, and cancer control. Because it is a cooperative agreement (U54), awardees should expect substantial NIH/NCI program involvement in shaping, coordinating, and monitoring program activities compared with a standard research project grant.

This funding announcement is described as a limited competition, meaning it is targeted to a defined group of applicants and partnership configurations rather than being fully open to all comers. It supports two main pathways: first, it funds the implementation and operation of active “Comprehensive Partnerships” under the U54 mechanism; second, it is explicitly meant to elevate the strongest partnerships that have been developing under a planning mechanism (U56 awards) into full comprehensive status. In practice, that emphasis signals that NCI is looking for mature, well-structured collaborations that can demonstrate readiness to move beyond planning into sustained, integrated research, career development, and community- and population-relevant cancer activities that address inequities.

The program sits within NIH’s broader cancer mission areas and can touch many parts of the cancer research and workforce ecosystem. The listed CFDA coverage spans essentially the full cancer continuum and supporting infrastructure, including cancer cause and prevention, detection and diagnosis, treatment, biology, cancer centers support, cancer research manpower, and cancer control. That breadth reinforces that CPACHE partnerships are not meant to be narrow, single-project collaborations; they are intended to be comprehensive, multi-component efforts that strengthen institutions, investigators, and pipelines while producing cancer research and training that is directly relevant to disparity-affected communities.

Eligible applicants include a range of U.S.-based higher education institutions and organizations, with a strong emphasis on institutions that historically and currently serve populations experiencing health disparities. The eligibility language explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs), along with other public and state-controlled institutions of higher education, private institutions of higher education, federally recognized tribal governments, and other Native American tribal organizations. Certain nonprofit entities are also eligible, including 501(c)(3) nonprofits and some nonprofits without 501(c)(3) status (as specified), reflecting flexibility in who can serve as an applicant organization when aligned with the FOA’s purpose. U.S. territories or possessions are included as eligible locations. Foreign institutions, non-U.S. components of U.S. organizations, and foreign components as defined by the NIH Grants Policy Statement are not allowed, keeping the program focused on domestic capacity-building and domestic disparity populations.

Administratively, the opportunity is categorized as discretionary funding and uses the cooperative agreement instrument type. It was posted and created on December 9, 2011, with an original and current closing date of January 28, 2014, and an archive date of February 28, 2014, indicating that this specific announcement is no longer active but remains useful as a reference point for how NCI structured CPACHE at the time. The FOA states there is no cost-sharing or matching requirement, so applicants were not required to contribute non-federal matching funds as a condition of award.

Overall, CPACHE (U54) is best understood as an NCI-supported partnership framework meant to strengthen cancer research, training, and programmatic capacity in institutions anchored in disparity-affected communities, while linking them tightly with the expertise, infrastructure, and clinical-research environments of NCI-designated Cancer Centers. The expected outcome is not only stronger institutions and more competitive investigators, but also more credible, community-relevant evidence about the drivers of cancer inequities and more effective strategies to reduce those inequities over time. For the complete archived announcement and any associated details on required components, review criteria, and program structure, the FOA is linked at http://grants.nih.gov/grants/guide/pa-files/PAR-12-055.html.

FAQs: Limited Competition Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54)

What is the CPACHE (U54) funding opportunity?

CPACHE (U54) is a National Cancer Institute (NCI) cooperative agreement program focused on building and strengthening long-term, formal partnerships between institutions that serve communities experiencing cancer health disparities and NCI-designated Cancer Centers (or consortia of Cancer Centers). The aim is to develop comprehensive, multi-component collaborations that improve cancer research and training efforts connected to disparity-affected communities.

What is the Funding Opportunity Number (FON) for this announcement?

The Funding Opportunity Number is PAR 12-055.

Which NIH institute is sponsoring this opportunity?

This opportunity is sponsored by the National Cancer Institute (NCI).

What does it mean that this is a cooperative agreement (U54)?

A U54 is a cooperative agreement mechanism, which means awardees should expect substantial NIH/NCI program involvement in shaping, coordinating, and monitoring program activities compared with a standard research project grant. In other words, NCI plays a more active role in the program after award.

What is the central goal of CPACHE (U54)?

The central goal is to build stronger, more connected national cancer research and training efforts that can better explain why major cancer disparities persist across certain populations and translate that understanding into practical improvements across the cancer continuum, including prevention, detection, diagnosis, treatment, survivorship, and cancer control.

Why does the announcement describe this as a "limited competition"?

It is described as a limited competition because it is targeted to a defined group of applicants and partnership configurations rather than being fully open to all applicants. The emphasis is on specific kinds of institutional partnerships aligned with the program purpose.

What types of partnerships is CPACHE designed to support?

CPACHE is designed to deepen and formalize collaborations between institutions that serve populations experiencing cancer health disparities and NCI-designated Cancer Centers (or consortia of Cancer Centers). The program is intended to create comprehensive, long-term partnerships rather than isolated or short-term collaborations.

What are the two main pathways supported under this announcement?

The announcement supports two pathways: (1) implementation and operation of active "Comprehensive Partnerships" under the U54 mechanism, and (2) elevating the strongest partnerships that had been developing under a planning mechanism (U56 awards) into full comprehensive partnership status under U54.

Does this program prioritize partnerships that previously held U56 planning awards?

Yes. The announcement explicitly emphasizes elevating the strongest partnerships that have been developing under U56 planning awards into full comprehensive status under the U54 mechanism, signaling a preference for mature, well-structured collaborations that are ready to operate as sustained programs.

What kinds of activities is CPACHE intended to support?

Based on the description provided, CPACHE is meant to support sustained, integrated efforts that include research, career development, and community- and population-relevant cancer activities. The program is framed as comprehensive and intended to address inequities across the cancer continuum.

Is CPACHE meant to fund single research projects?

No. The program is described as not being a narrow, single-project collaboration. Instead, it is intended to be comprehensive and multi-component, strengthening institutions, investigators, and pipelines while producing cancer research and training that is directly relevant to communities affected by disparities.

Which parts of the cancer continuum can CPACHE address?

The program is described as spanning the full cancer continuum and related infrastructure, including cancer cause and prevention, detection and diagnosis, treatment, biology, cancer centers support, cancer research manpower, and cancer control.

What populations or communities are the focus of CPACHE?

The focus is on communities experiencing cancer health disparities. The program is built around institutions that historically and currently serve populations affected by disparities, with the goal of generating community-relevant evidence and strategies to reduce inequities.

What types of organizations are eligible to apply?

Eligible applicants include a range of U.S.-based higher education institutions and organizations, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), other public and state-controlled institutions of higher education, private institutions of higher education, federally recognized tribal governments, and other Native American tribal organizations. Certain nonprofit entities are also eligible, including 501(c)(3) nonprofits and some nonprofits without 501(c)(3) status (as specified in the eligibility language described).

Are U.S. territories or possessions eligible locations?

Yes. U.S. territories or possessions are included as eligible locations.

Are foreign institutions eligible to apply?

No. Foreign institutions are not allowed under this announcement.

Are non-U.S. components of U.S. organizations allowed?

No. Non-U.S. components of U.S. organizations are not allowed.

Are foreign components (as defined by the NIH Grants Policy Statement) allowed?

No. Foreign components, as defined by the NIH Grants Policy Statement, are not allowed.

What type of funding is this categorized as?

It is categorized as discretionary funding.

Is cost-sharing or matching required?

No. The announcement states there is no cost-sharing or matching requirement.

When was this funding opportunity posted?

It was posted (and created) on December 9, 2011.

What were the closing and archive dates for this announcement?

The original and current closing date listed is January 28, 2014, and the archive date is February 28, 2014.

Is this specific CPACHE (U54) announcement still active?

No. Based on the closing and archive dates provided, this specific announcement is no longer active, but it remains available as an archived reference for how NCI structured CPACHE at that time.

What outcomes is CPACHE (U54) trying to achieve?

The expected outcomes include stronger institutions and more competitive investigators, along with more credible, community-relevant evidence about the drivers of cancer inequities and more effective strategies to reduce those inequities over time.

Where can someone find the complete archived funding announcement?

The archived FOA is available at: http://grants.nih.gov/grants/guide/pa-files/PAR-12-055.html

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Funding Number: RFA CA 12 002
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Validation and Advanced Development of Emerging Technologies for Cancer Research (R33) Apply for RFA CA 12 003

Funding Number: RFA CA 12 003
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Innovative and Early Stage Development of Emerging Technologies in Biospecimen Science (R21) Apply for RFA CA 12 004

Funding Number: RFA CA 12 004
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Funding Amount: $200,000
Validation and Advanced Development of Emerging Technologies in Biospecimen Science (R33) Apply for RFA CA 12 005

Funding Number: RFA CA 12 005
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NCI Established Investigator Award in Cancer Prevention and Control (K05) Apply for PAR 12 065

Funding Number: PAR 12 065
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Imaging Science Track Award for Research Transition (I/START) R03 Apply for PAR 12 066

Funding Number: PAR 12 066
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Human Health and Heredity in Africa (H3Africa) Research Grants (U01) Apply for RFA RM 12 004

Funding Number: RFA RM 12 004
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Small Grants for Behavioral Research in Cancer Control (R03) Apply for PAR 12 035

Funding Number: PAR 12 035
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Cancer Prevention, Control, Behavioral Sciences, and Population Sciences Career Development Award (K07) Apply for PAR 12 067

Funding Number: PAR 12 067
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Fogarty HIV Research Training Program for Low and Middle Income Country Institutions (D43) Apply for PAR 12 068

Funding Number: PAR 12 068
Agency: National Institutes of Health
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Pediatric Phase 1/Pilot Consortium (Limited Competition UM1) Apply for RFA CA 12 502

Funding Number: RFA CA 12 502
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Funding Number: PA 12 083
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