Opportunity Information: Apply for RFA AA 16 001
Apply for RFA AA 16 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition Consortia for HIV/AIDS and Alcohol Related Research Trials (CHAART) Project (Collaborative U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Jul 8, 2015 and posted on Jul 8, 2015.
- Applicants must submit their applications by Jan 15, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $7,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 15 candidate(s).
- Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Limited Competition Consortia for HIV/AIDS and Alcohol Related Research Trials (CHAART) Project (Collaborative U01) was a National Institutes of Health (NIH) cooperative agreement funding opportunity (RFA-AA-16-001) designed to strengthen and expand research at the intersection of alcohol use and HIV/AIDS. The central aim was to support operations and implementation research that can be carried out in real-world health and service settings, with a clear emphasis on both measuring the combined burden of alcohol and HIV and testing practical interventions that reduce harm. In other words, the program was built to move beyond basic science questions and focus on how systems, programs, and clinical or community practices can be improved to reduce HIV-related morbidity and mortality that are worsened by alcohol, while also addressing alcohol-related outcomes that complicate HIV prevention and care.
A major theme of the announcement was developing a broader, systems-level approach for monitoring complex outcomes. This includes improving how researchers and health systems track and understand patterns of HIV and alcohol-related illness and death, especially when these outcomes are influenced by multiple interacting factors such as adherence to antiretroviral therapy, co-occurring mental health conditions, social determinants, and access to care. By encouraging a systems approach, the FOA signaled interest in research that can integrate data across settings (for example, clinics, public health surveillance, and community services) and that can model or monitor outcomes that are not simple or isolated. The intent was to improve visibility into how alcohol affects HIV disease progression and transmission dynamics at both individual and population levels, including outcomes that may be missed by narrower clinical endpoints.
The second major theme was intervention-focused work aimed at reducing the impact of alcohol on HIV disease progression and transmission. The FOA emphasized testing strategies that can realistically be implemented, scaled, and sustained in the contexts where people receive HIV prevention and treatment services. This could include implementation research on screening and brief interventions, linkage to alcohol treatment, adherence support approaches tailored for people with unhealthy alcohol use, or integrated care models that coordinate HIV treatment with behavioral health and substance use services. Because the mechanism was a cooperative agreement (U01), NIH anticipated substantial programmatic involvement, meaning projects were expected to operate as part of a coordinated research effort rather than as isolated investigator-driven studies. The word "collaborative" in the title and the emphasis on consortia indicates that awardees were expected to align methods, share information, and contribute to a broader research enterprise focused on HIV and alcohol-related outcomes.
The opportunity was explicitly aligned with priorities in the Trans-NIH Plan for HIV-Related Research, which underscores that NIH viewed alcohol as a significant cross-cutting factor affecting HIV prevention, treatment, and long-term outcomes. By situating this initiative within that plan, the FOA highlighted the expectation that funded work would meaningfully contribute to national HIV research priorities, such as improving the effectiveness of HIV care delivery, reducing transmission, and addressing comorbidities and real-world barriers that undermine treatment success.
From an administrative and funding perspective, this was a discretionary health-related opportunity using the cooperative agreement funding instrument. NIH anticipated up to 15 awards, with an estimated total funding level of about $7,000,000. The award ceiling was listed as $500,000, which suggests an intent to fund multiple moderately sized projects that collectively advance the consortium goals rather than a small number of very large awards. There was no cost-sharing or matching requirement, which is typical for NIH research funding and lowers barriers for eligible academic applicants.
Eligibility was limited primarily to U.S.-based public or private institutions of higher education, including public and state-controlled universities. Foreign institutions were not eligible to apply, and non-U.S. components of U.S. organizations were also not eligible to apply as applicant organizations. However, foreign components, as defined by the NIH Grants Policy Statement, were allowed, which generally means a U.S. applicant could include certain foreign collaborations or activities when scientifically justified and compliant with NIH policy, even though a foreign institution could not serve as the applicant organization.
Key dates show the FOA was posted on July 8, 2015, with an original and current closing date of January 15, 2016, and an archive date of February 15, 2016, indicating the competition is no longer active. The CFDA number associated with the program was 93.273 (Alcohol Research Programs), reflecting the involvement of NIH alcohol research priorities, likely led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within the NIH structure.
Overall, the CHAART Project U01 opportunity was intended to build a coordinated set of research projects that improve how health systems and researchers measure the intertwined impacts of alcohol and HIV, and that test interventions capable of reducing alcohol-related harms that drive worse HIV outcomes. The consortium framing, combined with the cooperative agreement mechanism, points to a coordinated, multi-project approach where NIH and awardees work closely to generate evidence that can be translated into improved practice, policy, and service delivery for populations affected by both HIV and unhealthy alcohol use.
FAQs: Limited Competition Consortia for HIV/AIDS and Alcohol Related Research Trials (CHAART) Project (Collaborative U01)
What is the CHAART Project (Collaborative U01) funding opportunity?
The CHAART Project was a National Institutes of Health (NIH) cooperative agreement funding opportunity (RFA-AA-16-001) focused on strengthening and expanding research at the intersection of alcohol use and HIV/AIDS. It supported research designed for real-world health and service settings, with an emphasis on measuring the combined burden of alcohol and HIV and testing practical interventions to reduce harm.
What was the central aim of this program?
The central aim was to support operations and implementation research that can be carried out in real-world clinical and service environments. The program emphasized (1) improved measurement and monitoring of combined HIV and alcohol-related outcomes and (2) testing interventions that reduce HIV-related morbidity and mortality worsened by alcohol while also addressing alcohol-related outcomes that complicate HIV prevention and care.
Was this opportunity focused on basic science or applied research?
It was explicitly framed to move beyond basic science questions and toward systems, programs, and clinical or community practices that can be improved in real-world settings to reduce harm related to HIV and unhealthy alcohol use.
What kinds of research settings were emphasized?
The opportunity emphasized real-world health and service settings. Examples mentioned include clinics, public health surveillance systems, and community services, with an interest in integrating information across these kinds of settings.
What were the major themes of the funding announcement?
Two major themes were highlighted: (1) developing broader, systems-level approaches for monitoring complex outcomes related to HIV and alcohol, and (2) intervention-focused work to reduce the impact of alcohol on HIV disease progression and transmission, with an emphasis on strategies that can be implemented, scaled, and sustained.
What does a "systems-level approach" mean in the context of CHAART?
In this context, a systems-level approach refers to improving how researchers and health systems track and understand patterns of HIV and alcohol-related illness and death when outcomes are influenced by multiple interacting factors (such as antiretroviral therapy adherence, co-occurring mental health conditions, social determinants, and access to care). It also includes integrating data across multiple settings and monitoring outcomes that are not simple or isolated.
What kinds of outcomes was the FOA interested in measuring?
The FOA emphasized complex, intertwined outcomes related to alcohol use and HIV, including how alcohol affects HIV disease progression and transmission dynamics at both individual and population levels. It also highlighted interest in outcomes that may be missed by narrower clinical endpoints.
What types of interventions were encouraged?
The FOA emphasized intervention and implementation research aimed at reducing the impact of alcohol on HIV disease progression and transmission. Examples mentioned include screening and brief interventions, linkage to alcohol treatment, adherence support tailored for people with unhealthy alcohol use, and integrated care models that coordinate HIV treatment with behavioral health and substance use services.
What does it mean that this was a U01 cooperative agreement?
A U01 is a cooperative agreement mechanism. In this opportunity, NIH anticipated substantial programmatic involvement, meaning projects were expected to operate as part of a coordinated research effort rather than as isolated investigator-driven studies.
Why does the opportunity emphasize "collaborative" and "consortia"?
The announcement framed the work as a consortium effort, indicating that awardees were expected to align methods, share information, and contribute to a broader coordinated research enterprise focused on HIV and alcohol-related outcomes.
How was this opportunity aligned with broader NIH priorities?
The FOA was explicitly aligned with priorities in the Trans-NIH Plan for HIV-Related Research. This alignment signaled that NIH viewed alcohol as a significant cross-cutting factor affecting HIV prevention, treatment, and long-term outcomes, and that funded work was expected to contribute to national HIV research priorities.
What was the funding agency and likely NIH institute involved?
The funding opportunity was offered through the National Institutes of Health (NIH). Based on the alcohol research focus and the associated CFDA listing (93.273, Alcohol Research Programs), it reflects NIH alcohol research priorities and is likely associated with the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within NIH.
How many awards were anticipated and what was the estimated total funding?
NIH anticipated up to 15 awards, with an estimated total funding level of about $7,000,000.
What was the award ceiling?
The award ceiling was listed as $500,000, suggesting an intent to fund multiple moderately sized projects that collectively advance the consortium goals.
Was cost-sharing or matching required?
No. The opportunity stated there was no cost-sharing or matching requirement.
Who was eligible to apply?
Eligibility was limited primarily to U.S.-based public or private institutions of higher education, including public and state-controlled universities.
Could foreign institutions apply as the applicant organization?
No. Foreign institutions were not eligible to apply as applicant organizations.
Could a non-U.S. component of a U.S. organization apply?
No. Non-U.S. components of U.S. organizations were also not eligible to apply as applicant organizations.
Are any foreign activities or collaborations allowed?
Yes. While foreign institutions could not be the applicant organization, foreign components (as defined by the NIH Grants Policy Statement) were allowed, meaning a U.S. applicant could include certain foreign collaborations or activities when scientifically justified and consistent with NIH policy.
What were the key dates for this opportunity?
The FOA was posted on July 8, 2015. The original and current closing date was January 15, 2016. The archive date was February 15, 2016.
Is this funding opportunity still active?
No. The listed closing date (January 15, 2016) and archive date (February 15, 2016) indicate the competition is no longer active.
What was the CFDA number associated with the program?
The CFDA number associated with the program was 93.273 (Alcohol Research Programs).
What was the overall purpose of funding CHAART consortia projects?
The overall purpose was to build a coordinated set of research projects that (1) improve how health systems and researchers measure the intertwined impacts of alcohol and HIV and (2) test interventions capable of reducing alcohol-related harms that drive worse HIV outcomes, with the intent that findings could translate into improved practice, policy, and service delivery.
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