Opportunity Information: Apply for RFA DK 09 501
Apply for RFA DK 09 501
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Limited Competition Continuation of the Clinical Islet Transplantation (CIT) Consortium (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jan 13, 2009 and posted on Jan 13, 2009.
- Applicants must submit their applications by Mar 19, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $30,000,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses County governments Special district governments City or township governments Private institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Limited Competition Continuation of the Clinical Islet Transplantation (CIT) Consortium (U01)" (Funding Opportunity Number RFA-DK-09-501) is a National Institutes of Health (NIH) funding announcement led by two NIH institutes: the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Allergy and Infectious Diseases (NIAID). It was posted on January 13, 2009, with an application due date of March 19, 2009, and it later archived on April 19, 2009. The core aim is not to launch a brand-new consortium or open competition to entirely new teams, but to continue and finish work already underway within the existing Clinical Islet Transplantation (CIT) Consortium.
The purpose of the announcement is very specific and narrow: it invites applications only from institutions and organizations that were already being funded under earlier CIT Consortium funding solicitations (RFA DK 04-004 and RFA DK 04-005). This is why it is described as a limited competition. In practical terms, the NIH is using this FOA to support a continuation phase so that current consortium participants can complete the human islet transplantation clinical protocols that were already designed and initiated, along with the associated mechanistic studies. The emphasis on completing "currently designed" protocols signals that the expectation is to carry forward planned clinical and translational activities rather than propose unrelated or substantially redesigned projects.
The funding mechanism is a cooperative agreement using the U01 activity code. A U01 is different from a standard research project grant because it typically includes substantial federal scientific and/or programmatic involvement. In a consortium setting, this structure is often used when NIH expects active coordination across multiple clinical sites and supporting laboratories, common protocols, shared milestones, harmonized data collection, and close alignment with program goals. The cooperative agreement format also tends to support centralized management approaches that are important for multi-site clinical research, such as consistent clinical standards, comparable mechanistic assays, and coordinated oversight.
Financially, NIH anticipated a total of 30 million dollars in funding spread over three years, with up to ten awards expected. That combination of a large total budget and multiple anticipated awards fits the kind of networked clinical program this represents, where several clinical centers and supporting groups may be funded in parallel to execute transplants, follow participants, collect mechanistic samples, and conduct immunologic and metabolic analyses that explain outcomes.
In terms of what fields and public health areas it falls under, the announcement is categorized within health-related research and is associated with CFDA numbers 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), 93.855 (Allergy, Immunology and Transplantation Research), and 93.856 (Microbiology and Infectious Diseases Research). That mix reflects the interdisciplinary nature of islet transplantation: it is directly relevant to diabetes treatment, but it also relies heavily on transplant immunology and infection-related considerations due to immunosuppression and immune monitoring.
The opportunity states that there is no cost sharing or matching requirement. This means applicants were not required to commit institutional matching funds as a condition of eligibility, which is consistent with many NIH research funding opportunities.
Eligibility is broad in the general sense, listing many categories of applicants such as for-profit organizations (including small businesses and other for-profits), nonprofits with and without 501(c)(3) status, public and private institutions of higher education, and various levels of government (state, county, city/township, special district), as well as tribal governments and public housing authorities/Indian housing authorities. It also explicitly includes a range of institution types often highlighted in federal funding, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), and U.S. territories or possessions. Foreign organizations and other non-domestic entities are also mentioned among "other eligible applicants." That said, the practical gatekeeper for this particular FOA is the limited-competition restriction: only organizations already supported under the prior CIT Consortium RFAs (DK 04-004 and DK 04-005) are the intended applicant pool, regardless of how broad the general eligibility list appears.
The announcement is administered by NIH, and the full text was made available through the NIH grants guide page linked in the opportunity details. For technical issues accessing the electronic announcement, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which reflects the administrative nature of the contact rather than a scientific/program official point of contact in the excerpt provided.
Overall, this FOA is best understood as a continuation and completion funding pathway for an existing NIH-supported clinical research consortium focused on human islet transplantation, structured as a cooperative agreement to maintain coordinated, multi-site execution of established clinical protocols and accompanying mechanistic studies, with substantial multi-year investment to bring the planned consortium work to completion.
Frequently Asked Questions (FAQs)
What is the official title and funding opportunity number for this grant?
The opportunity is titled "Limited Competition Continuation of the Clinical Islet Transplantation (CIT) Consortium (U01)" and the Funding Opportunity Number is RFA-DK-09-501.
Which federal agency and NIH institutes are sponsoring this opportunity?
This is a National Institutes of Health (NIH) funding announcement led by two NIH institutes: the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Allergy and Infectious Diseases (NIAID).
When was the announcement posted, when were applications due, and when was it archived?
The announcement was posted on January 13, 2009. The application due date was March 19, 2009. The opportunity was later archived on April 19, 2009.
What is the main purpose of this funding opportunity?
The purpose is to continue and finish work already underway within the existing Clinical Islet Transplantation (CIT) Consortium, including completing human islet transplantation clinical protocols that were already designed and initiated, along with associated mechanistic studies.
Is this opportunity intended to create a brand-new consortium?
No. The aim is not to launch a brand-new consortium or open competition to entirely new teams. It is designed as a continuation phase for the existing CIT Consortium so current participants can complete planned work.
Is this a limited competition? If so, what does that mean here?
Yes, it is a limited competition. In practical terms, applications are invited only from institutions and organizations that were already being funded under earlier CIT Consortium funding solicitations (RFA DK 04-004 and RFA DK 04-005).
Who is eligible to apply?
While the general eligibility list includes many organization types (for-profit and nonprofit entities, higher education institutions, and various government and tribal entities, among others), the controlling eligibility requirement for this FOA is that applicants must be institutions/organizations already supported under the prior CIT Consortium RFAs (DK 04-004 and DK 04-005).
The eligibility list seems broad. Can a new organization apply if it fits one of those categories?
Based on the information provided, no. Even though many categories are named as eligible applicants, this FOA is specifically intended only for organizations already funded under RFA DK 04-004 and RFA DK 04-005.
What funding mechanism is used for this program?
The funding mechanism is a cooperative agreement using the U01 activity code.
What does a U01 cooperative agreement imply for how the project is run?
A U01 typically includes substantial federal scientific and/or programmatic involvement. In a consortium context, this often means NIH expects active coordination across multiple clinical sites and supporting laboratories, use of common protocols, shared milestones, harmonized data collection, and close alignment with program goals.
What kinds of activities are expected to be supported under this continuation?
The emphasis is on carrying forward and completing the currently designed and initiated human islet transplantation clinical protocols and the associated mechanistic (clinical/translational) studies, rather than proposing unrelated or substantially redesigned projects.
How much funding did NIH anticipate for this opportunity?
NIH anticipated a total of $30 million in funding spread over three years.
How many awards were expected?
Up to ten awards were expected.
Over what time period was the anticipated funding planned?
The anticipated total funding amount was planned to be spread over three years.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What research and public health areas does this opportunity relate to?
It is health-related research centered on human islet transplantation, with interdisciplinary relevance to diabetes treatment, transplant immunology, and infection-related considerations (including issues tied to immunosuppression and immune monitoring).
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), 93.855 (Allergy, Immunology and Transplantation Research), and 93.856 (Microbiology and Infectious Diseases Research).
Where was the full text of the announcement available?
The full text was made available through the NIH grants guide page linked in the opportunity details.
Who is the listed contact for technical problems accessing the electronic announcement?
The listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Is the listed contact a scientific/program contact?
Based on the excerpt provided, the listed contact is for technical issues accessing the electronic announcement and reflects an administrative/technical contact rather than a scientific or program official.
Why are both NIDDK and NIAID involved in this program?
The involvement of both institutes aligns with the interdisciplinary nature of clinical islet transplantation: it is directly relevant to diabetes (NIDDK) and also relies heavily on transplant immunology and infection-related considerations (NIAID), especially due to immunosuppression and immune monitoring.
What is the simplest way to describe what this FOA is trying to accomplish?
It is a continuation and completion funding pathway for an existing NIH-supported, multi-site clinical research consortium focused on human islet transplantation, structured as a U01 cooperative agreement to maintain coordinated execution of established clinical protocols and accompanying mechanistic studies.
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