Opportunity Information: Apply for RFA DK 14 505
Apply for RFA DK 14 505
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Limited Competition Data Coordinating Center for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (UC4)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Jun 25, 2014 and posted on Jun 25, 2014.
- Applicants must submit their applications by Dec 2, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $20,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $20,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Only the currently awardee for RFA 12 510 is eligible to apply to this Funding Opportunity Announcement. Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) announced a one-time, limited-competition cooperative agreement opportunity titled "Limited Competition Data Coordinating Center for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (UC4)" under Funding Opportunity Number RFA-DK-14-505. The purpose of this award is to continue supporting the TEDDY Study Data Coordinating Center (DCC), which has been responsible since the beginning of the TEDDY consortium for core functions such as study design support, overall coordination, and the acquisition and management of study data and biosamples. TEDDY itself is a large, ongoing epidemiological effort focused on understanding environmental contributors to diabetes in youth, and this announcement is designed to keep the coordinating backbone in place while expanding the study's analytic reach.
A central goal of the award is to enable the TEDDY DCC to set up an open competition process to bring in outside collaborators for large-scale ("Big Data") analyses. The FOA makes clear that collaborators are expected to be capable of integrating and analyzing diverse, complex data streams, not just traditional clinical outcomes. The types of information highlighted include multi-omics data (for example, genomics or other molecular profiling), diet records, clinical data, environmental analytes, and other related datasets generated through the TEDDY effort. In practical terms, the DCC is expected to act as the hub that makes these different data types usable together, which usually means harmonizing formats, standardizing metadata and variables, ensuring quality control, and supporting cross-domain analyses that can connect biology, exposures, and clinical endpoints.
The announcement also emphasizes accessibility and modern data-sharing approaches. It indicates that both the data and the analytics tools should be made available to TEDDY investigators using the most effective sharing methods, and it explicitly points to the option of a secure cloud environment. That suggests NIH wanted the DCC to move beyond traditional local or site-by-site data distribution and instead support scalable computing and controlled access, where approved researchers can run analyses close to the data. This kind of setup can reduce duplication, improve reproducibility, and better protect sensitive participant information through centralized governance and logging, while still enabling broad scientific use within the consortium.
In addition to building the platform for open collaborative analytics, the FOA is intended to support subject follow-up during the final year of the award period. That component signals that the DCC is not only a data warehouse or analytics support unit, but also remains directly involved in operational coordination that helps ensure the study completes its planned participant tracking and data collection activities, especially as the project approaches a transition point.
This was a discretionary funding opportunity using a cooperative agreement mechanism (UC4), which generally means NIH expected to have substantial programmatic involvement rather than simply providing funds and stepping back. The activity category is listed under food and nutrition and health, and the associated CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), aligning the opportunity with NIH's diabetes and metabolic disease research mission.
The funding scale was substantial: the FOA anticipated a single award (Expected Awards: 1) with an estimated total funding level of $20,000,000 and an award ceiling of $20,000,000. No cost sharing or matching was required. The opportunity was posted on June 25, 2014, with an original and current closing date of December 2, 2014, and it was archived on January 2, 2015.
Eligibility was extremely restricted. Only the current awardee under RFA DK-12-510, specifically the existing TEDDY DCC leadership (the PD/PI of that DCC award), was eligible to apply. Foreign institutions were not eligible, non-U.S. components of U.S. organizations were not eligible, and foreign components (as defined by NIH policy) were not allowed. In other words, this was not an open call for new coordinating centers; it was a targeted continuation and expansion award aimed at the established DCC already running TEDDY's coordinating infrastructure, with a new emphasis on enabling broader, competitive collaborations for sophisticated multi-source data analysis.
For full details, NIH provided an additional information link to the archived FOA page on the NIH grants website (http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-505.html). For technical issues accessing the announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Limited Competition Data Coordinating Center for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (UC4)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DK-14-505.
What type of award mechanism is being used?
This opportunity uses a cooperative agreement mechanism (UC4), which generally indicates substantial NIH programmatic involvement during the project.
Is this a one-time opportunity or an ongoing/open solicitation?
It is described as a one-time, limited-competition cooperative agreement opportunity.
What is the overall purpose of the award?
The purpose is to continue supporting the TEDDY Study Data Coordinating Center (DCC) and to maintain core coordinating functions while expanding the study's analytic reach, including enabling an open competition process to bring in outside collaborators for large-scale ("Big Data") analyses.
What is TEDDY, in the context of this announcement?
TEDDY is a large, ongoing epidemiological effort focused on understanding environmental contributors to diabetes in youth.
What is the TEDDY Data Coordinating Center (DCC) expected to do under this award?
The TEDDY DCC is expected to continue serving as the coordinating backbone for the consortium, including study design support, overall coordination, and the acquisition and management of study data and biosamples.
What new or emphasized role does the FOA assign to the DCC?
A central goal is for the DCC to set up an open competition process to bring in outside collaborators for large-scale analyses and to support integration and analysis of diverse, complex datasets generated by TEDDY.
What does the FOA mean by "Big Data" analyses in this context?
It refers to large-scale analyses that can integrate and analyze diverse, complex data streams beyond traditional clinical outcomes.
What kinds of data are specifically mentioned as targets for integration and analysis?
The FOA highlights multi-omics data (for example, genomics or other molecular profiling), diet records, clinical data, environmental analytes, and other related datasets produced through TEDDY.
What does it mean for the DCC to act as a "hub" for these data types?
In practical terms, the DCC is expected to make different data types usable together, which typically involves harmonizing formats, standardizing metadata and variables, performing quality control, and supporting cross-domain analyses connecting biology, exposures, and clinical endpoints.
How does the FOA address data and tool sharing with TEDDY investigators?
The announcement emphasizes accessibility and modern data-sharing approaches, stating that both data and analytics tools should be made available to TEDDY investigators using the most effective sharing methods.
Does the FOA mention using cloud computing?
Yes. It explicitly points to the option of a secure cloud environment for sharing data and analytics tools.
Why would a secure cloud environment be relevant to this award?
The FOA suggests moving beyond traditional site-by-site distribution toward scalable computing and controlled access, where approved researchers can run analyses close to the data. This can support reproducibility, reduce duplication, and strengthen protection of sensitive participant information through centralized governance and logging.
Does the award include operational responsibilities beyond data coordination and analytics?
Yes. The FOA is also intended to support subject follow-up during the final year of the award period, indicating the DCC remains involved in operational coordination for participant tracking and data collection as the project approaches a transition point.
How many awards did NIH expect to make under this FOA?
The FOA anticipated a single award (Expected Awards: 1).
What is the estimated total funding level for this opportunity?
The estimated total funding level is $20,000,000.
What is the award ceiling?
The award ceiling is $20,000,000.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching was required.
When was the opportunity posted?
The opportunity was posted on June 25, 2014.
What was the closing date for applications?
The original and current closing date was December 2, 2014.
Is this funding opportunity still active?
No. It was archived on January 2, 2015.
Who was eligible to apply?
Eligibility was extremely restricted. Only the current awardee under RFA DK-12-510, specifically the existing TEDDY DCC leadership (the PD/PI of that DCC award), was eligible to apply.
Were foreign institutions eligible to apply?
No. Foreign institutions were not eligible.
Were non-U.S. components of U.S. organizations allowed?
No. Non-U.S. components of U.S. organizations were not eligible.
Were foreign components (as defined by NIH policy) allowed?
No. Foreign components were not allowed under this FOA.
Does this FOA represent an open call to establish a new data coordinating center?
No. It was a targeted continuation and expansion award aimed at the established TEDDY DCC already operating the consortium's coordinating infrastructure.
What NIH program area does this opportunity align with?
The activity category is listed under food and nutrition and health, and it aligns with NIH diabetes and metabolic disease research through the associated program listing.
What CFDA number is associated with this funding opportunity?
The associated CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Where can someone find the archived FOA details?
NIH provided an archived FOA page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-505.html
Who was listed as the contact for technical issues accessing the announcement?
For technical issues accessing the announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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