Opportunity Information: Apply for RFA DK 12 507
Apply for RFA DK 12 507
- The National Institutes of Health in the food and nutrition health income security and social services sector is offering a public funding opportunity titled "Limited Competition for Continuation of the Prospective Study of Chronic Kidney Disease in Children (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Aug 31, 2012 and posted on Aug 31, 2012.
- Applicants must submit their applications by Nov 14, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,200,000.00 to eligible and selected applicants.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This grant opportunity, RFA-DK-12-507, is a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) funding announcement to continue the long-running Chronic Kidney Disease in Children (CKiD) prospective study under a U01 Cooperative Agreement mechanism. It is a limited competition, meaning it is not open to new outside teams in the usual way. Instead, NIDDK is inviting applications only from the already-established CKiD infrastructure: the two Clinical Coordinating Centers (CCCs), the Data Coordinating Center (DCC), and the Central Biochemistry Laboratory (CBL) that are currently part of the consortium. The intent is to maintain continuity of the cohort, preserve the value of years of prior data collection, and extend the study in ways that deepen what can be learned about pediatric chronic kidney disease (CKD) over time.
The core purpose is to continue the prospective, longitudinal follow-up of children with CKD who are already enrolled, while also allowing the clinical centers to recruit additional participants so the cohort remains robust and scientifically useful. The clinical centers are expected to keep conducting standardized participant evaluations and study visits, while working in a coordinated, consortium-based structure with the existing DCC and CBL. In practical terms, this means the clinical sites continue to collect clinical, demographic, and outcomes data from participants; the DCC continues to manage data systems, quality control, and likely statistical coordination; and the central laboratory continues to perform standardized biochemical measurements so results are comparable across sites and across time.
A key feature of this continuation is that some evaluation domains will be expanded, indicating that the ongoing protocol is expected to add depth in certain areas rather than simply repeating earlier assessments. Another major change is that follow-up will extend beyond the onset of end stage renal disease (ESRD). That is an important scientific point because it allows the study to capture outcomes and trajectories not only during progressive CKD, but also after transition to ESRD, when children may start dialysis or receive a kidney transplant. Extending observation past ESRD can improve understanding of long-term health, complications, and factors that influence outcomes across the full disease course.
Administratively, this is a discretionary federal funding opportunity using the Cooperative Agreement (U01) instrument, which generally implies substantial NIH programmatic involvement compared with a standard research grant. The announcement lists an estimated total funding level of about $3.2 million. It also notes there is no cost sharing or matching requirement. The opportunity was posted on August 31, 2012, with an application closing date of November 14, 2012, and an archive date of December 15, 2012.
Eligibility is constrained by design. The announcement indicates the applicants are the existing CKiD consortium components (the two CCCs, the DCC, and the CBL). Foreign institutions (non-U.S. entities) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible; however, foreign components as defined under the NIH Grants Policy Statement are allowed, which typically means a U.S. applicant organization may include certain foreign activities or collaborations if they meet NIH definitions and requirements.
The opportunity is associated with multiple CFDA numbers reflecting relevant NIH research areas, including cardiovascular diseases research (93.837), diabetes/digestive/kidney diseases extramural research (93.847), and child health and human development extramural research (93.865). For full details, NIDDK provided an Additional Information link to the complete announcement on the NIH grants website, and the contact listed for access or linking problems is the NIH Office of Extramural Research (OER) Webmaster.
Frequently Asked Questions (FAQs) - RFA-DK-12-507 (CKiD Study Continuation)
What is this grant opportunity?
RFA-DK-12-507 is a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) funding announcement to continue the long-running Chronic Kidney Disease in Children (CKiD) prospective study. It supports continued longitudinal follow-up of children with chronic kidney disease (CKD) under a U01 Cooperative Agreement mechanism.
What is the main goal of the funding announcement?
The main goal is to preserve continuity of the existing CKiD cohort and the scientific value of years of prior data collection, while extending and deepening what can be learned about pediatric CKD over time. The study will continue prospective, standardized follow-up of currently enrolled participants and allow recruitment of additional participants to keep the cohort robust.
Is this opportunity open to new applicants?
No. This is a limited competition. NIDDK is inviting applications only from the already-established CKiD infrastructure: the two Clinical Coordinating Centers (CCCs), the Data Coordinating Center (DCC), and the Central Biochemistry Laboratory (CBL) that are currently part of the consortium.
Who is eligible to apply?
Eligibility is restricted to the existing CKiD consortium components: the two Clinical Coordinating Centers (CCCs), the Data Coordinating Center (DCC), and the Central Biochemistry Laboratory (CBL).
Are foreign institutions eligible to apply?
No. Foreign institutions (non-U.S. entities) are not eligible to apply. Non-U.S. components of U.S. organizations are also not eligible. However, foreign components (as defined under the NIH Grants Policy Statement) are allowed, meaning a U.S. applicant organization may include certain foreign activities or collaborations if they meet NIH definitions and requirements.
What funding mechanism is being used?
The award mechanism is a U01 Cooperative Agreement. This generally means there is substantial NIH programmatic involvement compared with a standard research project grant.
What does a Cooperative Agreement (U01) imply for how the project is run?
Based on the announcement description, the project is expected to operate in a coordinated, consortium-based structure with continued involvement from NIDDK under the cooperative agreement model. The CCCs, DCC, and CBL continue their defined roles while working together to maintain standardized data and measurements across sites and over time.
What parts of the CKiD consortium are included in this continuation?
The continuation includes the two Clinical Coordinating Centers (CCCs), the Data Coordinating Center (DCC), and the Central Biochemistry Laboratory (CBL) that are already part of the CKiD consortium.
What will the Clinical Coordinating Centers (CCCs) do under this continuation?
The clinical centers are expected to continue conducting standardized participant evaluations and study visits, and to collect clinical, demographic, and outcomes data from participants. They may also recruit additional participants so the cohort remains scientifically useful over time.
What will the Data Coordinating Center (DCC) do under this continuation?
The DCC is expected to continue managing data systems and quality control and to provide coordinating functions (including likely statistical coordination) to support the consortium-wide study operations.
What will the Central Biochemistry Laboratory (CBL) do under this continuation?
The CBL is expected to continue performing standardized biochemical measurements so results remain comparable across clinical sites and across time.
Does the study continue to follow children already enrolled in CKiD?
Yes. A core purpose is continued prospective, longitudinal follow-up of children with CKD who are already enrolled in the cohort.
Can the clinical centers enroll new participants?
Yes. The continuation allows the clinical centers to recruit additional participants so the cohort remains robust and scientifically useful.
Will the protocol change, or is it simply a continuation of prior assessments?
The announcement indicates that some evaluation domains will be expanded. This suggests the ongoing protocol is expected to add depth in certain areas rather than only repeating earlier assessments.
What is a major scientific change in the follow-up plan?
A major change is that follow-up will extend beyond the onset of end stage renal disease (ESRD). This enables the study to capture outcomes and trajectories after transition to ESRD, including periods when children may begin dialysis or receive a kidney transplant.
Why is extending follow-up beyond ESRD important in this study?
Extending observation past ESRD can improve understanding of long-term health, complications, and factors influencing outcomes across the full disease course, not only during progressive CKD but also after transition to ESRD.
How much funding is available?
The announcement lists an estimated total funding level of about $3.2 million.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What are the key dates for this opportunity?
The opportunity was posted on August 31, 2012. The application closing date is November 14, 2012. The archive date is December 15, 2012.
What agency and institute are sponsoring this opportunity?
This is an NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) funding announcement. NIDDK is part of the National Institutes of Health (NIH).
What research areas or CFDA numbers are associated with this announcement?
The opportunity is associated with multiple CFDA numbers, including 93.837 (cardiovascular diseases research), 93.847 (diabetes/digestive/kidney diseases extramural research), and 93.865 (child health and human development extramural research).
Where can applicants find the complete announcement details?
NIDDK provided an Additional Information link to the complete announcement on the NIH grants website.
Who is listed as the contact for access or linking problems?
The contact listed for access or linking problems is the NIH Office of Extramural Research (OER) Webmaster.
Does this opportunity emphasize continuity of data and standardization across sites?
Yes. The continuation is explicitly intended to preserve the value of prior data collection, maintain standardized participant evaluations at clinical sites, and continue centralized, standardized biochemical measurements so results remain comparable across sites and over time.
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