Opportunity Information: Apply for RFA DK 16 510
Apply for RFA DK 16 510
- The Department of Health and Human Services, National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on Aug 17, 2016.
- Applicants must submit their applications by Dec 14, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,062,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
This funding opportunity is a limited-competition NIH cooperative agreement (U24) from the Department of Health and Human Services, National Institutes of Health (NIH), specifically the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It supports a single Data Coordinating Center (DCC) for the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC), a long-running program started in 2002 to discover genetic factors that predispose people to inflammatory bowel disease (IBD). While the consortium and its international partners have already identified roughly 200 IBD susceptibility loci, the announcement highlights a major remaining gap: many loci contain multiple genes, and for most loci the true causal genes and specific risk or protective alleles are still not pinned down. Another core gap is biological interpretation, since the mechanisms connecting many of these genetic signals to IBD pathophysiology remain unclear. The overarching goal of the renewal described in this FOA is therefore twofold: (1) move from loci to specific causal genes and variants (including both risk-conferring and protective variants), and (2) clarify how those variants influence disease biology.
The DCC is positioned as the operational and analytic hub that makes the consortium function as one integrated study rather than a set of separate sites. A central responsibility is to coordinate collaboration among the Genetic Research Centers (GRCs) that enroll participants and generate data (the GRCs are solicited under a companion FOA, RFA-DK-16-029). The DCC is expected to organize and standardize enrollment workflows across sites, ensure that subjects are properly brought into the study under harmonized procedures, and oversee the movement of biospecimens and data through the consortium pipeline. This includes coordinating the submission of blood and other biological samples to centralized repositories and managing processing steps for blood samples such as DNA extraction and the isolation of cells and serum. In practice, that means the DCC is accountable for making sure biospecimens are handled consistently, tracked accurately, and prepared in ways that support downstream genetic and molecular analyses.
On the data side, the DCC is responsible for coordinating the submission of clinical, genetic, and molecular datasets into central databases and supporting consortium-wide analyses. This implies building and maintaining the informatics and governance processes needed for large multi-site data aggregation, quality control, harmonization of clinical variables, and integration of genomic and molecular information at scale. Because this is a cooperative agreement, the DCC is not just a service provider; it is a partner in consortium science and is expected to play an active role in cross-center analytic planning and execution, including enabling the kinds of integrated analyses required to identify causal variants and connect them to biological mechanisms.
A substantial portion of the DCC role is also governance and coordination. The DCC manages the operations of the IBDGC Steering Committee and other operational committees, which typically means scheduling and supporting meetings, documenting decisions, implementing agreed-upon policies, tracking milestones, and ensuring that operational decisions are carried out consistently across all participating centers. The FOA explicitly states that the DCC Program Director/Principal Investigator (PD/PI) will serve as a voting member of the Steering Committee and will be bound by the committee's operational decisions, reinforcing that leadership is shared and that consortium policies govern how work is conducted.
Beyond routine coordination, the DCC is also tasked with enabling fast-moving science through pilot projects. The FOA calls for the DCC to coordinate the development of pilot projects designed for rapid follow-up of emerging findings, whether those findings arise within the IBDGC or through external collaborators. This emphasizes agility: when new genetic signals, candidate mechanisms, or promising leads emerge, the DCC helps organize short-turnaround efforts to validate, replicate, or functionally explore them across the consortium infrastructure.
Finally, the FOA places strong emphasis on external collaboration. The DCC is expected to coordinate interaction not only among domestic GRCs, but also with the International IBD Genetics Consortium and other outside investigators conducting ancillary studies. This suggests the DCC must be capable of supporting data sharing and collaborative workflows that cross institutional and national boundaries, while maintaining consistent standards for data submission, sample handling, and analysis approaches.
Key administrative details included in the announcement are that the opportunity is titled "Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24)" with Funding Opportunity Number RFA DK 16 510, released/created August 17, 2016, and originally closing December 14, 2016. The mechanism is a cooperative agreement, and the program is categorized under health (CFDA 93.847). Only one award was expected, with an award ceiling listed at $1,062,000. Eligibility is broad and includes many types of U.S. organizations, such as various levels of government, public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (including small businesses), tribal governments and organizations, and other applicants as permitted by the FOA's additional eligibility language.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a limited-competition NIH cooperative agreement (U24) to support a single Data Coordinating Center (DCC) for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Inflammatory Bowel Disease Genetics Consortium (IBDGC).
Which agency is offering the award?
The award is offered by the U.S. Department of Health and Human Services, National Institutes of Health (NIH), specifically NIDDK.
What is the official title of the opportunity?
The opportunity is titled: "Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA DK 16 510.
When was this FOA released, and when did it originally close?
The FOA was released/created on August 17, 2016, and it originally closed on December 14, 2016.
What is the funding mechanism and what does it imply?
The mechanism is a cooperative agreement (U24). Based on the FOA description, this implies the DCC is an active partner in consortium activities and analysis (not only a service center), and it will operate within shared consortium governance (for example, via Steering Committee decisions).
How many awards are expected?
Only one award was expected, meaning a single organization will serve as the DCC for the consortium under this FOA.
What is the award ceiling?
The award ceiling listed is $1,062,000.
What CFDA program category is associated with this opportunity?
The program is categorized under health, CFDA 93.847.
What is the IBD Genetics Consortium (IBDGC) and why does it exist?
The IBDGC is a long-running program started in 2002 to discover genetic factors that predispose people to inflammatory bowel disease (IBD). The consortium and partners have already identified roughly 200 IBD susceptibility loci, but the FOA highlights remaining gaps around pinpointing causal genes/alleles and interpreting the biological mechanisms behind many genetic signals.
What are the main scientific goals emphasized in this renewal?
The FOA describes two overarching goals: (1) move from loci to specific causal genes and variants (including both risk-conferring and protective variants), and (2) clarify how those variants influence disease biology and IBD pathophysiology.
What is the role of the Data Coordinating Center (DCC) in the consortium?
The DCC is described as the operational and analytic hub that enables the IBDGC to function as one integrated study rather than separate sites. It coordinates collaboration across participating centers, standardizes workflows, manages data and biospecimen pipelines, supports consortium-wide analyses, and runs key governance and coordination functions.
How does the DCC relate to the Genetic Research Centers (GRCs)?
The DCC coordinates collaboration among the Genetic Research Centers (GRCs), which are the centers that enroll participants and generate data. The FOA references that the GRCs are solicited under a companion FOA (RFA-DK-16-029).
What kinds of operational coordination is the DCC expected to provide across sites?
The FOA expects the DCC to organize and standardize enrollment workflows across sites, ensure harmonized procedures for bringing subjects into the study, and oversee the movement of biospecimens and data through the consortium pipeline.
What biospecimen responsibilities are described for the DCC?
The DCC is expected to coordinate submission of blood and other biological samples to centralized repositories, and to manage or oversee processing steps for blood samples such as DNA extraction and isolation of cells and serum. The FOA frames the DCC as accountable for consistent handling, accurate tracking, and preparation of biospecimens to support downstream genetic and molecular analyses.
What are the DCC responsibilities for data submission and databases?
The DCC is responsible for coordinating the submission of clinical, genetic, and molecular datasets into central databases, and for supporting consortium-wide analyses. This implies building and maintaining the informatics and governance processes needed for multi-site aggregation, quality control, harmonization of clinical variables, and integration of genomic and molecular data at scale.
Is the DCC expected to participate in scientific and analytic work, or only provide administrative support?
The FOA indicates the DCC is not just a service provider. As part of a cooperative agreement, it is expected to play an active role in cross-center analytic planning and execution, enabling integrated analyses aimed at identifying causal variants and connecting them to biological mechanisms.
What governance and committee responsibilities does the DCC have?
The DCC manages the operations of the IBDGC Steering Committee and other operational committees. Responsibilities typically include scheduling and supporting meetings, documenting decisions, implementing policies, tracking milestones, and ensuring decisions are carried out consistently across participating centers.
What is the role of the DCC PD/PI within consortium governance?
The FOA states the DCC Program Director/Principal Investigator (PD/PI) will serve as a voting member of the Steering Committee and will be bound by the committee's operational decisions, reflecting shared leadership and governance through consortium policies.
What are pilot projects, and what is the DCC expected to do with them?
The FOA calls for the DCC to coordinate development of pilot projects designed for rapid follow-up of emerging findings, whether identified within the IBDGC or through external collaborators. The intent is to support short-turnaround efforts to validate, replicate, or functionally explore promising leads using consortium infrastructure.
How important is external collaboration in this FOA?
External collaboration is emphasized. The DCC is expected to coordinate interactions not only among domestic GRCs, but also with the International IBD Genetics Consortium and other outside investigators conducting ancillary studies, supporting cross-institutional and cross-national collaboration while maintaining consistent standards for samples, data submission, and analysis approaches.
Who is eligible to apply?
Eligibility is described as broad and includes many types of U.S. organizations, such as various levels of government, public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (including small businesses), tribal governments and organizations, and other applicants as permitted by the FOA's additional eligibility language.
Is this opportunity limited-competition, and what does that mean in this context?
Yes. The FOA is explicitly described as a limited-competition opportunity. The description also indicates only one award was expected, reinforcing that the FOA is intended to support a single DCC for the consortium.
What makes this DCC central to the consortium?
The FOA positions the DCC as the center that makes the consortium operate as an integrated study by standardizing workflows, coordinating subject enrollment procedures, ensuring consistent biospecimen handling and tracking, managing centralized data submission and harmonization, supporting consortium-wide analysis, and implementing governance decisions.
What kinds of data are explicitly mentioned as being coordinated by the DCC?
The FOA mentions clinical, genetic, and molecular datasets.
What types of biospecimen processing steps are explicitly mentioned?
The FOA explicitly mentions DNA extraction and isolation of cells and serum from blood samples.
Which companion FOA is referenced for the Genetic Research Centers (GRCs)?
The FOA references a companion solicitation for GRCs: RFA-DK-16-029.
What is the long-term scientific gap this FOA is trying to address?
Even though many IBD susceptibility loci have been identified, the FOA highlights that many loci contain multiple genes and that for most loci the true causal genes and specific risk or protective alleles are not yet pinned down. It also highlights a gap in biological interpretation, meaning the mechanisms linking genetic signals to IBD pathophysiology remain unclear for many findings.
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| NIDDK Information Network Coordinating Unit: dkNET-CU (U24) Apply for RFA DK 17 010 Funding Number: RFA DK 17 010 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $635,000 |
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