Opportunity Information: Apply for RFA DK 14 504
Apply for RFA DK 14 504
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of the Adult Acute Liver Failure Study Group (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Jul 18, 2014 and posted on Jul 18, 2014.
- Applicants must submit their applications by Nov 25, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $3,500,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Only current ALFSG awardees are eligible to apply to this FOA. Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
This grant opportunity, titled "Limited Competition for the Continuation of the Adult Acute Liver Failure Study Group (U01)" (Funding Opportunity Number RFA-DK-14-504), is a National Institutes of Health (NIH) cooperative agreement designed to extend and strengthen the work of the Adult Acute Liver Failure Study Group (ALFSG). The central aim is to keep the existing multi-center research network operating so it can continue enrolling patients with acute liver failure (ALF) into an ongoing clinical database, expand the number of well characterized patient biospecimens stored in a centralized repository, and support continued clinical research focused on the causes of ALF, potential treatments, and the major complications that arise during ALF.
A key emphasis of the announcement is continued patient enrollment and data capture. By increasing the number of ALF cases logged in a structured clinical database, the program seeks to improve the statistical power and overall usefulness of the dataset for answering clinically important questions. In parallel, the FOA prioritizes growth of a central biospecimen repository containing high-quality, well annotated samples tied to detailed clinical information. This combination of robust clinical data plus consistently collected biospecimens is meant to create a stronger foundation for future studies on disease mechanisms, prognostic markers, therapeutic targets, and management strategies for ALF and its downstream complications.
The funding mechanism is a U01 cooperative agreement, which typically indicates substantial scientific or programmatic involvement by NIH staff compared with a standard research project grant. In practical terms, this usually means the funded group and NIH work collaboratively on study priorities, operational decisions, and milestone-driven progress to ensure the network continues to meet the program goals of enrollment, repository development, and innovative clinical investigation. The activity category is listed under health (with a food and nutrition/health categorization in the listing), and the CFDA number associated with the opportunity is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), reflecting administration through NIH components that support research on digestive and liver diseases.
This is a limited competition, meaning eligibility is restricted. Only current ALFSG awardees are allowed to apply, which signals that the FOA is intended as a continuation award for an established consortium rather than an open call for new institutions to join. The announcement also clearly excludes foreign participation: foreign institutions cannot apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH Grants Policy) are not allowed. There is no cost sharing or matching requirement, so applicants are not required to commit non-federal funds as a condition of receiving the award.
In terms of funding scale, NIH anticipated making a single award (Expected Awards: 1) with an estimated total funding level of $3,500,000, and an award ceiling also listed at $3,500,000. The opportunity was posted on July 18, 2014, and the application due date closed on November 25, 2014, with the archive date shown as December 26, 2014. While the dates indicate this specific opportunity is no longer open, the details are still useful for understanding the scope, structure, and continuation intent of the ALFSG program at that time.
For applicants or stakeholders seeking the official announcement text, NIH provided an additional information link to the full FOA on the NIH Grants Guide website (http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-504.html). For technical access problems, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV, specifically for issues accessing the announcement electronically or linking to the funding notice.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Limited Competition for the Continuation of the Adult Acute Liver Failure Study Group (U01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DK-14-504.
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What type of award mechanism is used?
The mechanism is a U01 cooperative agreement.
What does it mean that this is a U01 cooperative agreement?
A U01 cooperative agreement typically involves substantial scientific or programmatic involvement by NIH staff compared with a standard research project grant. In practical terms, NIH and the funded group generally work collaboratively on study priorities, operational decisions, and milestone-driven progress.
What program or network is this FOA intended to continue?
The FOA is designed to extend and strengthen the work of the Adult Acute Liver Failure Study Group (ALFSG), an existing multi-center research network.
What is the central aim of the funding opportunity?
The central aim is to keep the existing ALFSG multi-center network operating so it can continue enrolling patients with acute liver failure (ALF) into an ongoing clinical database, expand a centralized biospecimen repository, and support continued clinical research on ALF causes, treatments, and major complications.
What disease area or condition is the focus of this opportunity?
The focus is acute liver failure (ALF), including its causes, potential treatments, and major complications occurring during ALF.
What activities are emphasized as priorities in this announcement?
The announcement emphasizes continued patient enrollment and structured data capture in a clinical database, along with growth of a central repository of well characterized, well annotated biospecimens linked to detailed clinical information.
Why is continued patient enrollment and data capture important in this program?
By increasing the number of ALF cases logged in a structured clinical database, the program seeks to improve the statistical power and overall usefulness of the dataset for answering clinically important questions.
What is the purpose of expanding the biospecimen repository?
The purpose is to increase the number of high-quality, well annotated patient biospecimens stored in a centralized repository and tied to detailed clinical data. This combination is intended to support future studies on disease mechanisms, prognostic markers, therapeutic targets, and management strategies for ALF and its complications.
Is this an open competition or a limited competition?
This is a limited competition.
Who is eligible to apply?
Eligibility is restricted to current Adult Acute Liver Failure Study Group (ALFSG) awardees. This indicates the FOA is intended as a continuation award for an established consortium rather than an open call for new institutions.
Are foreign institutions eligible to apply?
No. Foreign institutions cannot apply under this announcement.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under NIH Grants Policy definitions?
No. Foreign components (as defined by NIH Grants Policy) are not allowed.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement stated for this opportunity.
How many awards did NIH expect to make?
NIH anticipated making a single award (Expected Awards: 1).
What was the estimated total funding level for this opportunity?
The estimated total funding level was $3,500,000.
What was the award ceiling?
The award ceiling was listed as $3,500,000.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
How is the activity category described?
The activity category is listed under health (with a food and nutrition/health categorization in the listing).
When was this opportunity posted?
The opportunity was posted on July 18, 2014.
What was the application due date?
The application due date was November 25, 2014.
What was the archive date?
The archive date was December 26, 2014.
Is this funding opportunity still open?
No. The dates provided indicate this specific opportunity is no longer open.
Where can someone find the official FOA announcement text?
The full FOA was made available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-504.html
Who is the contact for technical problems accessing the announcement online?
For technical access problems (such as issues accessing the announcement electronically or linking to the funding notice), the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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| Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Scientific and Data Coordinating Center (PLUS SDCC) (U01) Apply for RFA DK 14 018 Funding Number: RFA DK 14 018 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Prevention of Lower Urinary Tract Symptoms in Women Bladder Health Clinical Centers (PLUS CCs) (U01) Apply for RFA DK 14 004 Funding Number: RFA DK 14 004 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
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| Identification of Novel Targets and Pathways Mediating Weight Loss, Diabetes Resolution and Related Metabolic Disease after Bariatric Surgery in Humans (R01) Apply for RFA DK 14 025 Funding Number: RFA DK 14 025 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
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| Limited Competition for the Continuation of the Hepatitis B Research Network Immunology Center (U01) Apply for RFA DK 14 509 Funding Number: RFA DK 14 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Hepatitis B Research Network Data Coordination Center (U01) Apply for RFA DK 14 510 Funding Number: RFA DK 14 510 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Type 1 Diabetes Complications IMPACT Award (DP3) Apply for RFA DK 14 017 Funding Number: RFA DK 14 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $2,000,000 |
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| (Re)Building a Kidney Coordinating Center (U01) Apply for RFA DK 14 009 Funding Number: RFA DK 14 009 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $1,600,000 |
| (Re)Building a Kidney Cells to Organ (UH2/UH3) Apply for RFA DK 14 010 Funding Number: RFA DK 14 010 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Psychosocial and Behavioral Aspects of Bariatric Surgery (R01) Apply for RFA DK 14 026 Funding Number: RFA DK 14 026 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4) Apply for RFA DK 14 508 Funding Number: RFA DK 14 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Innovative Research in HIV in Kidney, Urology and Hematology (R01) Apply for RFA DK 14 020 Funding Number: RFA DK 14 020 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Elucidating HIV and HIV treatment Associated Metabolic/Endocrine Dysfunction (R01) Apply for RFA DK 14 023 Funding Number: RFA DK 14 023 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Food Specific Molecular Profiles and Biomarkers of Food and Nutrient Intake, and Dietary Exposure (R01) Apply for PAR 15 024 Funding Number: PAR 15 024 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Administrative Supplements for Human Islet Research (Admin Supp) Apply for PA 15 025 Funding Number: PA 15 025 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $100,000 |
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