Opportunity Information: Apply for RFA DK 12 508
Apply for RFA DK 12 508
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Sep 6, 2012 and posted on Sep 6, 2012.
- Applicants must submit their applications by Nov 14, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $7,920,000.00 to eligible and selected applicants.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Faith based or Community based Organizations Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01) is a National Institutes of Health (NIH) funding opportunity issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to keep the CRIC Study operating for an additional five years. This is a continuation-focused, limited competition announcement, meaning it is not open to the general research community. Instead, it is specifically designed for the existing CRIC Study awardees so they can maintain the established infrastructure, preserve long term follow-up, and extend the scientific value of a cohort that has been tracked for many years.
At its core, CRIC is a multi-center, prospective, observational cohort study that follows men and women living with chronic kidney disease (CKD). Because it is observational, the study is structured around ongoing measurement and monitoring rather than testing an experimental treatment. The network includes seven Clinical Centers and their satellite sites, along with a Scientific and Data Coordinating Center that supports standardized data collection, data quality, management, and analysis across the consortium. The cohort was originally established in 2001 and recruited roughly 3,600 participants, creating a large, well-characterized population that can be followed over time to understand how CKD progresses and how it affects other major health outcomes.
The main purpose of this particular funding opportunity is to continue follow-up of the originally recruited CRIC participants, rather than launching a brand new cohort. NIDDK emphasizes the importance of sustained tracking to answer questions that only long-term data can address, such as why some people experience rapid loss of kidney function while others decline more slowly, and how CKD contributes to serious cardiovascular disease over time. The FOA also highlights a deeper look at morbidity in CKD, which broadly includes the complications and burdens patients experience (for example, hospitalizations, functional decline, and other health consequences that accompany reduced kidney function). Another explicit focus is understanding CKD in elderly persons, reflecting the reality that kidney disease and its complications often intersect with aging, multimorbidity, and higher vulnerability to adverse outcomes.
Administratively, this opportunity is issued as a cooperative agreement (U01), which generally means NIH expects substantial involvement with awardees during the project period. The funding opportunity number is RFA-DK-12-508, and it was posted on September 6, 2012. The original and current closing date listed is November 14, 2012, with an archive date of December 15, 2012, indicating this is a historical announcement rather than an open, current competition. The estimated total funding amount is $7,920,000, and no cost sharing or matching is required. The activity falls under the NIH CFDA listing 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Eligibility is intentionally narrow. Only organizations that are already serving as grantees for the CRIC Study are eligible to apply under this limited competition, which is meant to ensure continuity of operations and prevent disruption to the cohort and its established protocols. The announcement also states that non-U.S. (foreign) institutions cannot apply, non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed as defined by NIH policy. The listing mentions additional eligible applicant types such as faith-based or community-based organizations, but in practice those provisions are constrained by the central rule that applicants must be current CRIC grantees.
In practical terms, this FOA is about protecting and extending a major national research resource: a longstanding CKD cohort with coordinated clinical sites and a central data center, positioned to answer high-impact questions about kidney disease progression, cardiovascular risk, overall illness burden, and aging-related outcomes. The full announcement is referenced through the NIH Grants Guide link provided in the source information.
FAQs: Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01)
1) What is this funding opportunity?
This is an NIH funding opportunity from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) titled "Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01)." It is designed to keep the CRIC Study operating for an additional five years by supporting continued follow-up of participants and continued operation of the existing study infrastructure.
2) What is the funding opportunity number (FOA number)?
The funding opportunity number is RFA-DK-12-508.
3) Who is the sponsoring agency and institute?
The opportunity is issued by the National Institutes of Health (NIH), specifically through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
4) What type of award mechanism is used?
The announcement uses a cooperative agreement mechanism (U01). This generally means NIH expects substantial involvement with awardees during the project period.
5) Is this an open competition for new applicants?
No. This is a continuation-focused, limited competition announcement and is not open to the general research community. It is specifically intended for the existing CRIC Study awardees (current CRIC Study grantees) to ensure continuity of operations and avoid disruption to the established cohort and protocols.
6) What is the main purpose of this FOA?
The main purpose is to continue long-term follow-up of the participants originally recruited into the CRIC Study, rather than starting a new cohort. NIDDK highlights the value of sustained tracking to address questions that require long-term data.
7) What is the CRIC Study, in plain terms?
CRIC is a multi-center, prospective, observational cohort study that follows men and women living with chronic kidney disease (CKD). Because it is observational, it focuses on ongoing measurement and monitoring over time rather than testing an experimental treatment.
8) When was the CRIC cohort originally established, and how large is it?
The cohort was originally established in 2001 and recruited roughly 3,600 participants, creating a large, well-characterized group that can be followed over time.
9) What does "multi-center" mean for this study?
The CRIC network includes seven Clinical Centers and their satellite sites, plus a Scientific and Data Coordinating Center that supports standardized data collection, data quality, management, and analysis across the consortium.
10) What research topics or outcomes are emphasized for continued follow-up?
The FOA emphasizes long-term questions such as why some people experience rapid loss of kidney function while others decline more slowly, and how CKD contributes to serious cardiovascular disease over time. It also highlights a deeper look at morbidity in CKD (the complications and burdens that accompany reduced kidney function) and an explicit focus on understanding CKD in elderly persons.
11) What does "morbidity in CKD" refer to in this FOA?
In this context, morbidity broadly includes complications and burdens experienced by patients with CKD, with examples noted such as hospitalizations, functional decline, and other health consequences that accompany reduced kidney function.
12) Why does the FOA call out CKD in elderly persons?
The FOA reflects the reality that kidney disease and its complications often intersect with aging, multimorbidity, and higher vulnerability to adverse outcomes, making long-term follow-up in older adults especially important.
13) How long is the continuation period described in this opportunity?
The continuation described is for an additional five years of CRIC Study operations and follow-up.
14) What is the estimated total funding amount?
The estimated total funding amount listed is $7,920,000.
15) Is cost sharing or matching required?
No. The announcement states that no cost sharing or matching is required.
16) What is the CFDA listing associated with this activity?
The activity falls under NIH CFDA 93.847, titled "Diabetes, Digestive, and Kidney Diseases Extramural Research."
17) Who is eligible to apply?
Eligibility is intentionally narrow. Only organizations that are already serving as grantees for the CRIC Study are eligible to apply under this limited competition.
18) Are non-U.S. (foreign) institutions eligible to apply?
No. The FOA states that non-U.S. (foreign) institutions cannot apply.
19) Are non-U.S. components of U.S. organizations eligible?
No. The announcement states that non-U.S. components of U.S. organizations are not eligible.
20) Are foreign components allowed under NIH policy for this FOA?
No. The FOA indicates that foreign components are not allowed as defined by NIH policy.
21) The FOA mentions faith-based or community-based organizations. Does that mean they can apply?
The listing mentions additional eligible applicant types such as faith-based or community-based organizations, but the central eligibility rule still applies: applicants must already be current CRIC Study grantees. In practice, that narrow requirement governs who can apply.
22) What does "continuation-focused" mean here?
It means the FOA is aimed at maintaining and extending the existing CRIC Study infrastructure and long-term participant follow-up, rather than creating a new cohort or building a new network from scratch.
23) What does NIH mean by preserving "infrastructure" and "long-term follow-up"?
Based on the description, this refers to maintaining the established multi-center consortium (Clinical Centers and satellite sites) and the Scientific and Data Coordinating Center, along with standardized processes for ongoing measurements, data collection, data quality, management, and analysis so participants can continue to be tracked consistently over time.
24) Is this a current, open opportunity?
No. The dates indicate it is a historical announcement rather than an open competition. It was posted on September 6, 2012, with a closing date listed as November 14, 2012, and an archive date of December 15, 2012.
25) Where is the full announcement referenced?
The full announcement is referenced through the NIH Grants Guide link provided in the source information.
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