Opportunity Information: Apply for RFA DK 14 506
Apply for RFA DK 14 506
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Aug 26, 2014 and posted on Aug 26, 2014.
- Applicants must submit their applications by Nov 25, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $7,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Only the current HBRN awardees are eligible to apply to this FOA.
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Opportunity Summary:
The grant opportunity titled "Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)" (Funding Opportunity Number RFA-DK-14-506) is a National Institutes of Health (NIH) cooperative agreement designed to keep the Hepatitis B Research Network (HBRN) Clinical Centers operating beyond their existing award period. The central goal is to sustain and strengthen a coordinated, multi-center clinical research infrastructure focused on translational hepatitis B research, meaning work that directly connects clinical observations and patient-based studies to improved understanding of disease mechanisms and to practical advances in prevention, treatment, and long-term control of hepatitis B virus (HBV) infection. The FOA specifically emphasizes research that clarifies HBV pathogenesis and the natural history of infection, while also supporting the development and evaluation of approaches that can improve patient outcomes and reduce the public health burden of hepatitis B.
This announcement is a limited competition, which is important because it is not open to the general research community. Eligibility is restricted to current HBRN awardees only, meaning only the institutions already funded as part of the existing HBRN Clinical Centers can apply. In practical terms, NIH is signaling that it intends to continue an established network rather than create a new one, reflecting the value of consistent cohorts, standardized protocols, experienced site teams, and long-running data and specimen resources that can be leveraged for longitudinal and comparative analyses. There is no cost-sharing or matching requirement, so applicants are not required to provide institutional matching funds as a condition of the award.
The funding mechanism is a U01 cooperative agreement. Compared with a traditional research grant, a cooperative agreement typically involves substantial NIH scientific and programmatic involvement during the project period. That generally means the network model will include close coordination between awardees and NIH staff, shared governance or steering structures, harmonized procedures across sites, and collaborative decision-making about protocol development, study conduct, data quality, and network priorities. This structure is well-suited to large, multi-site clinical research programs where consistent implementation, pooled datasets, and unified oversight are essential to producing reliable, generalizable results.
From an administrative standpoint, the opportunity falls under NIH with an activity category listed as health and is associated with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), indicating management through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) portfolio. The FOA was posted on August 26, 2014, with an application deadline of November 25, 2014. The total estimated funding level is listed as $7,000,000, reflecting support intended to maintain multiple clinical centers and the network functions necessary to run coordinated translational studies. The archive date is December 26, 2014, meaning the solicitation is no longer active, but the summary remains useful for understanding the scope and structure of the program and the types of activities NIH was seeking to support at that time.
In terms of what NIH is trying to accomplish scientifically, the continued operation of HBRN Clinical Centers is meant to accelerate progress on core unanswered questions in hepatitis B, such as why disease progression varies widely across individuals, how immune responses and viral factors interact over time, and what predicts key outcomes like cirrhosis, hepatocellular carcinoma risk, flares, or spontaneous control. By keeping a network of clinical centers in place, NIH can support standardized patient characterization, long-term follow-up, and the careful collection of clinical data and biospecimens that enable translational work, including biomarker development, improved disease phenotyping, and the identification of targets for therapy. The focus on developing "means of treatment and control" reflects an interest in moving beyond description toward actionable strategies, such as optimizing treatment approaches, refining monitoring and risk stratification, and supporting studies that could inform future interventional trials.
The FOA directs applicants and readers to the full announcement hosted on the NIH grants website, and it provides a practical contact pathway through the NIH Office of Extramural Research (OER) Webmaster for technical difficulties accessing the notice or links. Overall, this funding opportunity is best understood as a continuation award framework for an existing, tightly coordinated clinical research network dedicated to translating patient-based hepatitis B research into clearer understanding of disease mechanisms and improved options for managing and ultimately controlling HBV infection.
Frequently Asked Questions (FAQs)
1) What is the title of this grant opportunity?
The opportunity is titled "Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)."
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DK-14-506.
3) Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
4) Which NIH institute is associated with this program?
The opportunity is associated with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), reflected in the CFDA listing.
5) What funding mechanism is used (grant type)?
The mechanism is a U01 cooperative agreement.
6) What does it mean that this is a cooperative agreement (U01)?
A cooperative agreement typically involves substantial NIH scientific and programmatic involvement during the project period. In this network context, that generally implies close coordination between awardees and NIH staff, harmonized procedures across sites, and collaborative decision-making around protocol development, study conduct, data quality, and network priorities.
7) What is the purpose of this FOA?
The purpose is to continue operating the Hepatitis B Research Network (HBRN) Clinical Centers beyond their existing award period, sustaining and strengthening a coordinated multi-center clinical research infrastructure focused on translational hepatitis B research.
8) What is the central scientific goal of the continuation?
The central goal is to maintain a coordinated, multi-center platform that links clinical observations and patient-based studies to better understanding of hepatitis B virus (HBV) disease mechanisms and to practical advances in prevention, treatment, and long-term control of HBV infection.
9) What kinds of research does the FOA emphasize?
The FOA emphasizes translational hepatitis B research, including work that clarifies HBV pathogenesis and the natural history of infection, and supports developing and evaluating approaches intended to improve patient outcomes and reduce the public health burden of hepatitis B.
10) What major hepatitis B questions is the network intended to help address?
The continuation is aimed at accelerating progress on questions such as why disease progression varies across individuals, how immune responses and viral factors interact over time, and what predicts outcomes like cirrhosis, hepatocellular carcinoma risk, flares, or spontaneous control.
11) Why does NIH want to continue an existing network rather than create a new one?
The FOA signals NIH's intent to continue an established network, reflecting the value of consistent cohorts, standardized protocols, experienced site teams, and long-running data and specimen resources that can support longitudinal and comparative analyses.
12) Is this opportunity open to all applicants?
No. This is a limited competition and is not open to the general research community.
13) Who is eligible to apply?
Eligibility is restricted to current HBRN awardees only, meaning only institutions already funded as part of the existing HBRN Clinical Centers can apply.
14) Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement, so applicants are not required to provide institutional matching funds as a condition of the award.
15) What is the estimated total funding amount?
The total estimated funding level is $7,000,000, intended to support multiple clinical centers and the network functions needed to run coordinated translational studies.
16) What is the activity category for this opportunity?
The activity category is listed as health.
17) What CFDA number is associated with this FOA?
The CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
18) When was the FOA posted?
The FOA was posted on August 26, 2014.
19) What was the application deadline?
The application deadline was November 25, 2014.
20) Is this funding opportunity still active?
No. The archive date is December 26, 2014, which indicates the solicitation is no longer active.
21) If it is archived, why might the FOA still be useful?
Even though it is no longer active, the summary can still be useful for understanding the scope and structure of the program at that time, the continuation-network model NIH sought to support, and the kinds of translational hepatitis B activities the network was expected to enable.
22) What types of network capabilities does the FOA highlight as important?
The FOA highlights the importance of standardized patient characterization, long-term follow-up, and careful collection of clinical data and biospecimens that enable translational work, such as biomarker development, improved disease phenotyping, and identification of targets for therapy.
23) Does the FOA indicate an interest in moving beyond observational research?
Yes. The focus on developing "means of treatment and control" reflects an interest in moving beyond description toward actionable strategies such as optimizing treatment approaches, refining monitoring and risk stratification, and supporting studies that could inform future interventional trials.
24) Where is the full announcement hosted?
The FOA directs readers to the full announcement hosted on the NIH grants website.
25) Who can be contacted for technical issues accessing the notice or links?
The FOA provides a contact pathway through the NIH Office of Extramural Research (OER) Webmaster for technical difficulties accessing the notice or links.
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| Limited Competition for the Continuation of the Hepatitis B Research Network Immunology Center (U01) Apply for RFA DK 14 509 Funding Number: RFA DK 14 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Hepatitis B Research Network Data Coordination Center (U01) Apply for RFA DK 14 510 Funding Number: RFA DK 14 510 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Type 1 Diabetes Complications IMPACT Award (DP3) Apply for RFA DK 14 017 Funding Number: RFA DK 14 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $2,000,000 |
| Consortium on Beta cell Death and Survival (HIRN CBDS) (UC4) Apply for RFA DK 14 021 Funding Number: RFA DK 14 021 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $900,000 |
| (Re)Building a Kidney Coordinating Center (U01) Apply for RFA DK 14 009 Funding Number: RFA DK 14 009 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $1,600,000 |
| (Re)Building a Kidney Cells to Organ (UH2/UH3) Apply for RFA DK 14 010 Funding Number: RFA DK 14 010 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Psychosocial and Behavioral Aspects of Bariatric Surgery (R01) Apply for RFA DK 14 026 Funding Number: RFA DK 14 026 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4) Apply for RFA DK 14 508 Funding Number: RFA DK 14 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Innovative Research in HIV in Kidney, Urology and Hematology (R01) Apply for RFA DK 14 020 Funding Number: RFA DK 14 020 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Elucidating HIV and HIV treatment Associated Metabolic/Endocrine Dysfunction (R01) Apply for RFA DK 14 023 Funding Number: RFA DK 14 023 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $500,000 |
| Food Specific Molecular Profiles and Biomarkers of Food and Nutrient Intake, and Dietary Exposure (R01) Apply for PAR 15 024 Funding Number: PAR 15 024 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Administrative Supplements for Human Islet Research (Admin Supp) Apply for PA 15 025 Funding Number: PA 15 025 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $100,000 |
| Research on Eosinophil Associated Disorders (R01) Apply for PA 15 027 Funding Number: PA 15 027 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Research on Eosinophil Associated Disorders (R21) Apply for PA 15 028 Funding Number: PA 15 028 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $275,000 |
| Underactive Bladder in Aging (R01) Apply for PA 15 049 Funding Number: PA 15 049 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| USAID Child Blindness Program Apply for PGRD 14 0002 Funding Number: PGRD 14 0002 Agency: Agency for International Development Category: Food and Nutrition Health Funding Amount: $250,000 |
| Developmental Centers for Interdisciplinary Research in Benign Urology (P20) Apply for RFA DK 15 001 Funding Number: RFA DK 15 001 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| George M. OBrien Urology Cooperative Research Centers Program (U54) Apply for RFA DK 15 002 Funding Number: RFA DK 15 002 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $1,000,000 |
| NIDDK Multi Center Clinical Study Cooperative Agreement (U01) Apply for PAR 15 067 Funding Number: PAR 15 067 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| NIDDK Multi Center Clinical Study Implementation Planning Cooperative Agreements (U34) Apply for PAR 15 068 Funding Number: PAR 15 068 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $225,000 |
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